scholarly journals Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

2010 ◽  
Vol 127 (8) ◽  
pp. 1741-1747 ◽  
Author(s):  
William K.K. Wu ◽  
Guangshun Wang ◽  
Seth B. Coffelt ◽  
Aline M. Betancourt ◽  
Chung W. Lee ◽  
...  
Keyword(s):  
Host Defense ◽  
Human Cancer ◽  
Therapeutic Applications ◽  
Host Defense Peptide

84 LOSS OF SPROUTY2 PROMOTES COLONIC EXPRESSION OF THE HOST DEFENSE PEPTIDE RELMβ

2021 ◽  
Vol 160 (6) ◽  
pp. S-21
Author(s):  
Michael A. Schumacher ◽  
Cambrian Y. Liu ◽  
Jonathan J. Hsieh ◽  
Benjamin S. Purnell ◽  
Mark R. Frey
Keyword(s):  
Host Defense ◽  
Host Defense Peptide

scholarly journals Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections

Gene Therapy ◽  
2005 ◽  
Vol 12 (20) ◽  
pp. 1494-1502 ◽  
Author(s):  
F Jacobsen ◽  
D Mittler ◽  
T Hirsch ◽  
A Gerhards ◽  
M Lehnhardt ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Host Defense ◽  
Wound Infections ◽  
Burn Wound ◽  
Human Host ◽  
Host Defense Peptide ◽  
Adenoviral Gene Therapy

The host defense peptide LL-37 triggers release of nucleic acids from human mast cells

Peptides ◽  
2018 ◽  
Vol 109 ◽  
pp. 39-45 ◽  
Author(s):  
Sara Dahl ◽  
Emma Anders ◽  
Olof Gidlöf ◽  
Daniel Svensson ◽  
Bengt-Olof Nilsson
Keyword(s):  
Mast Cells ◽  
Nucleic Acids ◽  
Host Defense ◽  
Human Mast Cells ◽  
Host Defense Peptide

Dysregulation of miRNA in cancer progression

2021 ◽  
Author(s):  
Rucha P.
Keyword(s):  
Gene Regulation ◽  
Cancer Progression ◽  
Therapeutic Target ◽  
Chromosomal Abnormalities ◽  
Human Cancer ◽  
Epigenetic Modification ◽  
Therapeutic Applications ◽  
Non Coding Rnas ◽  
Transcriptional Gene Regulation

MicroRNAs (miRNAs) are a category of highly conserved tiny non-coding RNAs that play a role in post-transcriptional gene regulation. Numerous studies have shown the role of dysregulated miRNA in a variety of illnesses, including human cancer. MiRNA is dysregulated by a variety of processes, including dysregulation of miRNA synthesis, aberrant miRNA transcription, dysregulated epigenetic modification, and chromosomal abnormalities. MiRNAs that are overexpressed have been shown to influence cancer's hallmarks. Recent research has shown miRNA's potential as a therapeutic target and biomarker. In this review, we discussed the synthesis and regulation of miRNA, as well as its dysregulation in human cancer and other disorders, as well as some of the therapeutic applications of miRNA.

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