scholarly journals The impact of a 1‐hour time interval between pazopanib and subsequent intake of gastric acid suppressants on pazopanib exposure

2021 ◽  
Author(s):  
Stefanie D. Krens ◽  
Floor J. E. Lubberman ◽  
Marthe Egmond ◽  
Frank G. A. Jansman ◽  
David M. Burger ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Time Interval ◽  
The Impact ◽  
Subsequent Intake

scholarly journals Time-to-Treatment in Oral Cancer: Causes and Implications for Survival

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1321
Author(s):  
Constanza Saka-Herrán ◽  
Enric Jané-Salas ◽  
Antoni Mari-Roig ◽  
Albert Estrugo-Devesa ◽  
José López-López
Keyword(s):  
Oral Cancer ◽  
Previous Treatment ◽  
Diagnostic Procedures ◽  
Original Data ◽  
Primary Treatment ◽  
Medical Attention ◽  
Time Interval ◽  
Pre Treatment ◽  
The Impact ◽  
Lack Of Knowledge

The purpose of this review was to identify and describe the causes that influence the time-intervals in the pathway of diagnosis and treatment of oral cancer and to assess its impact on prognosis and survival. The review was structured according to the recommendations of the Aarhus statement, considering original data from individual studies and systematic reviews that reported outcomes related to the patient, diagnostic and pre-treatment intervals. The patient interval is the major contributor to the total time-interval. Unawareness of signs and/or symptoms, denial and lack of knowledge about oral cancer are the major contributors to the process of seeking medical attention. The diagnostic interval is influenced by tumor factors, delays in referral due to higher number of consultations and previous treatment with different medicines or dental procedures and by professional factors such as experience and lack of knowledge related to the disease and diagnostic procedures. Patients with advanced stage disease, primary treatment with radiotherapy, treatment at an academic facility and transitions in care are associated with prolonged pre-treatment intervals. An emerging body of evidence supports the impact of prolonged pre-treatment and treatment intervals with poorer survival from oral cancer.

scholarly journals The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2398
Author(s):  
Matteo Serenari ◽  
Enrico Prosperi ◽  
Marc-Antoine Allard ◽  
Michele Paterno ◽  
Nicolas Golse ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatic Resection ◽  
Primary Outcome ◽  
Polynomial Regression ◽  
Secondary Outcome ◽  
Time Interval ◽  
Comprehensive Complication Index ◽  
Fractional Polynomial ◽  
The Impact

Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death.

scholarly journals Effect of the Assimilation Frequency of Radar Reflectivity on Rain Storm Prediction by Using WRF-3DVAR

2021 ◽  
Vol 13 (11) ◽  
pp. 2103
Author(s):  
Yuchen Liu ◽  
Jia Liu ◽  
Chuanzhe Li ◽  
Fuliang Yu ◽  
Wei Wang
Keyword(s):  
Data Assimilation ◽  
Northern China ◽  
Horizontal Resolution ◽  
Radar Reflectivity ◽  
Small Scale ◽  
Time Interval ◽  
Outer Domain ◽  
Storm Prediction ◽  
The Impact ◽  
Assimilation Time

An attempt was made to evaluate the impact of assimilating Doppler Weather Radar (DWR) reflectivity together with Global Telecommunication System (GTS) data in the three-dimensional variational data assimilation (3DVAR) system of the Weather Research Forecast (WRF) model on rain storm prediction in Daqinghe basin of northern China. The aim of this study was to explore the potential effects of data assimilation frequency and to evaluate the outputs from different domain resolutions in improving the meso-scale NWP rainfall products. In this study, four numerical experiments (no assimilation, 1 and 6 h assimilation time interval with DWR and GTS at 1 km horizontal resolution, 6 h assimilation time interval with radar reflectivity, and GTS data at 3 km horizontal resolution) are carried out to evaluate the impact of data assimilation on prediction of convective rain storms. The results show that the assimilation of radar reflectivity and GTS data collectively enhanced the performance of the WRF-3DVAR system over the Beijing-Tianjin-Hebei region of northern China. It is indicated by the experimental results that the rapid update assimilation has a positive impact on the prediction of the location, tendency, and development of rain storms associated with the study area. In order to explore the influence of data assimilation in the outer domain on the output of the inner domain, the rainfall outputs of 3 and 1 km resolution are compared. The results show that the data assimilation in the outer domain has a positive effect on the output of the inner domain. Since the 3DVAR system is able to analyze certain small-scale and convective-scale features through the incorporation of radar observations, hourly assimilation time interval does not always significantly improve precipitation forecasts because of the inaccurate radar reflectivity observations. Therefore, before data assimilation, the validity of assimilation data should be judged as far as possible in advance, which can not only improve the prediction accuracy, but also improve the assimilation efficiency.

scholarly journals Financing Growth through Remittances and Foreign Direct Investment: Evidences from Balkan Countries

2021 ◽  
Vol 14 (3) ◽  
pp. 117
Author(s):  
Esmeralda Jushi ◽  
Eglantina Hysa ◽  
Arjona Cela ◽  
Mirela Panait ◽  
Marian Catalin Voica
Keyword(s):  
Developing Economies ◽  
Central Banks ◽  
Sustainable Growth ◽  
Time Interval ◽  
Foreign Direct Investments ◽  
Factors Affecting ◽  
Balkan Countries ◽  
To Come ◽  
Sustainable Economic Growth ◽  
The Impact

The ultimate goal of central banks, worldwide, is to promote the foundations for sustainable economic growth. In the case of developing economies, in particular, such objective requires time, huge efforts, attention, and plenty of resources in order to be accomplished to the fullest degree. This paper thoroughly investigates key factors affecting Balkan countries’ economic development (as measured by gross domestic product (GDP) growth), focusing especially on the impact of remittances. The analysis was done over an 18-year time interval (2000–2017) and builds on 144 observations. The data figures were retrieved from the World Bank database while two dummies were created to test the impact of the last financial crisis (2008–2012). Econometric tools were employed to carry out a broad analysis on the interdependencies that exist and, in particular, to determine the role of remittance income on growth. The vector auto regressive model was estimated using EViews software, and was used to come up with relevant insights. Empirical findings suggest the following: population growth, remittances, and labor force participation are insignificant factors for sustainable growth. On the other hand, previous levels of GDP, trade, and foreign direct investments (FDIs) appear to be relevant for the predictor. This research provides up-to-date conclusions, which can be considered during the decision-making process of central banks, as well as by government policymakers.

scholarly journals Imaging Appropriateness in Pediatric Radiology during COVID-19 Pandemic: A Retrospective Comparison with No COVID-19 Period

Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 463
Author(s):  
Giampiero Bottari ◽  
Giandomenico Stellacci ◽  
Davide Ferorelli ◽  
Alessandro Dell’Erba ◽  
Maurizio Aricò ◽  
...  
Keyword(s):  
Bone Fractures ◽  
Sharp Decrease ◽  
Pediatric Emergency ◽  
Time Interval ◽  
Imaging Studies ◽  
Retrospective Comparison ◽  
Imaging Appropriateness ◽  
Therapeutic Protocols ◽  
The Impact ◽  
Negative Imaging

During the COVID-19 pandemic, the number of accesses to the Pediatric Emergency Department (pED) in Italy sharply decreased by 30%. The purpose of this study is to evaluate how this novel setting impacted on management of children with trauma, and the use and appropriateness of imaging studies in such patients at the pED. All imaging studies performed in patients with trauma at the pED of a tertiary children’s Hospital during the first wave of the COVID-19 pandemic (between March and May 2020) were reviewed, in comparison with a control time interval (March to May 2019). In the pre-COVID control era, 669 imaging studies documented bone fractures in 145/568 children (25.5%). In the COVID-era, 79/177 (44.6%) pediatric patients showed bone fractures on 193 imaging studies. Comparative analysis shows a 71% decrease in imaging studies, and the proportion of negative imaging studies (with no evidence of bone fractures) dropped in 2020 by 19% compared to the 2019 control era (p < 0.001). The sharp decrease of negative studies suggests that the rate of appropriateness was higher during COVID-era, suggesting some attitude toward defensive medicine in the previous control year, as a result of some degree of imaging inappropriateness. The impact of a pandemic on emergency medicine may offer a unique opportunity to revisit diagnostic and therapeutic protocols in pediatrics.

scholarly journals Evaluation and Validation of a Joint Stress Test to Induce Activity-Related Knee Joint Discomfort — a Prospective Case-Control Study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Christiane Schön ◽  
Claudia Reule ◽  
Katharina Knaub ◽  
Antje Micka ◽  
Manfred Wilhelm ◽  
...  
Keyword(s):  
Knee Joint ◽  
Healthy Subjects ◽  
Stress Test ◽  
Osteoarthritis Of The Knee ◽  
Time Interval ◽  
Short Time Interval ◽  
Joint Stress ◽  
Joint Health ◽  
The Impact ◽  
Health Function

Abstract Background The assessment of improvement or maintenance of joint health in healthy subjects is a great challenge. The aim of the study was the evaluation of a joint stress test to assess joint discomfort in subjects with activity-related knee joint discomfort (ArJD). Results Forty-five subjects were recruited to perform the single-leg-step-down (SLSD) test (15 subjects per group). Subjects with ArJD of the knee (age 22–62 years) were compared to healthy subjects (age 24–59 years) with no knee joint discomfort during daily life sporting activity and to subjects with mild-to-moderate osteoarthritis of the knee joint (OA, Kellgren score 2–3, age 42–64 years). The subjects performed the SLSD test with two different protocols: (I) standardization for knee joint discomfort; (II) standardization for load on the knee joint. In addition, range of motion (ROM), reach test, acute pain at rest and after a single-leg squat and knee injury, and osteoarthritis outcome score (KOOS) were assessed. In OA and ArJD subjects, knee joint discomfort could be reproducibly induced in a short time interval of less than 10 min (200 steps). In healthy subjects, no pain was recorded. A clear differentiation between study groups was observed with the SLSD test (maximal step number) as well as KOOS questionnaire, ROM, and reach test. In addition, a moderate to good intra-class correlation was shown for the investigated outcomes. Conclusions These results suggest the SLSD test is a reliable tool for the assessment of knee joint health function in ArJD and OA subjects to study the improvements in their activities. Further, this model can be used as a stress model in intervention studies to study the impact of stress on knee joint health function.

scholarly journals Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 738
Author(s):  
Nazanin Samadi ◽  
Denise Heiden ◽  
Martina Klems ◽  
Martina Salzmann ◽  
Johanna Rohrhofer ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Gastric Acid ◽  
Clinical Symptoms ◽  
Acid Suppression ◽  
Gastric Digestion ◽  
Enzyme Solution ◽  
Allergic Symptoms ◽  
Gastric Acid Suppression ◽  
The Impact

Impaired gastric digestion due to suppressed gastric acidity enhances the risk for food allergy development. In the current study, we aimed to evaluate the impact of a supported gastric digestion via application of a pharmaceutical gastric enzyme solution (GES) on food allergy development and allergic reactions in a BALB/c mouse model. The ability of the GES to restore hypoacidic conditions was tested in mice treated with gastric acid suppression medication. To evaluate the impact on allergic symptoms, mice were orally sensitized with ovalbumin (OVA) under gastric acid suppression and subjected to oral challenges with or without GES. The immune response was evaluated by measurement of antibody titers, cytokine levels, mucosal allergy effector cell influx and regulatory T-cell counts. Clinical response was objectified by core body temperature measurements after oral OVA challenge. Supplementation of GES transiently restored physiological pH levels in the stomach after pharmaceutical gastric acid suppression. During oral sensitization, supplementation of gastric enzymes significantly reduced systemic IgE, IgG1 and IgG2a levels and allergic symptoms. In food allergic mice, clinical symptoms were reduced by co-administration of the gastric enzyme solution. Support of gastric digestion efficiently prevents food allergy induction and alleviates clinical symptoms in our food allergy model.

958 The impact of time interval from late preterm corticosteroid administration to delivery on neonatal outcomes

2021 ◽  
Vol 224 (2) ◽  
pp. S594-S595
Author(s):  
Moti Gulersen ◽  
Cynthia Gyamfi-Bannerman ◽  
Michelle Greenman ◽  
Erez Lenchner ◽  
Burton Rochelson ◽  
...  
Keyword(s):  
Neonatal Outcomes ◽  
Late Preterm ◽  
Time Interval ◽  
Corticosteroid Administration ◽  
The Impact
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