scholarly journals Cortical Bone Assessed With Clinical Computed Tomography at the Proximal Femur

2014 ◽  
Vol 29 (4) ◽  
pp. 771-783 ◽  
Author(s):  
Fjola Johannesdottir ◽  
Tom Turmezei ◽  
Kenneth ES Poole
1980 ◽  
Vol 59 (5) ◽  
pp. 393-395 ◽  
Author(s):  
U. Elsasser ◽  
R. Hesp ◽  
L. Klenerman ◽  
R. Wootton

1. The mean attenuation coefficients of trabecular and cortical bone in the radius were measured in 32 female patients with fractured proximal femur, and in 28 age-matched female controls, with a special-purpose computed tomography-scanner. 2. The largest difference between the two groups was in the mean attenuation coefficients for trabecular bone in the distal radius. The mean value for fracture patients (0.53 cm−1) was significantly lower (P < 0.02) than the mean value for the controls (0.62 cm−1). These results are consistent with the view that a loss of trabecular bone predisposes to fractures of the proximal femur.


Author(s):  
X. Sherry Liu ◽  
Adi Cohen ◽  
Perry T. Yin ◽  
Joan M. Lappe ◽  
Robert R. Recker ◽  
...  

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a promising clinical tool that permits separate measurements of trabecular and cortical bone compartments at the distal radius and tibia. It has an isotropic voxel size of 82 μm, which is high enough to assess the fine microstructural details of trabecular architecture. HR-pQCT images can also be used for building microstructural finite element (μFE) models to estimate the mechanical competence of whole bone segments. Melton et al. showed that derived bone strength parameters (axial rigidity and fall load to failure load ratio) are additional to BMD and bone geometry and microstructure as determinants of forearm fracture risk prediction [1]. Boutroy et al. found that the proportion of the load carried by trabecular bone versus cortical bone is associated with wrist fracture independently of BMD and microarchitecture [2]. These clinical studies demonstrate that HR-pQCT based μFE analyses can provide measurements of mechanical properties that independently associate with fracture risk. However, microstructure of one skeletal site may be different from that of another site. It is unclear whether and to what extent these peripheral measurements reflect the bone strength of the proximal femur and vertebral bodies, the sites of frequent osteoporotic fractures. Currently, central quantitative computed tomography (cQCT) is the most commonly used clinical imaging modality to quantify the structural and mechanical properties of the proximal femur and lumbar spine. We therefore evaluated relationships between the stiffness of the distal radius and tibia estimated by HR-pQCT-based FEA with that of the proximal femur and lumbar spine which was estimated from cQCT-based FEA in the same human subjects.


2009 ◽  
Vol 67 (3) ◽  
pp. 491-500 ◽  
Author(s):  
Denise Swasty ◽  
Janice S. Lee ◽  
John C. Huang ◽  
Koutaro Maki ◽  
Stuart A. Gansky ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document