Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men

Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients. The levels of sRAGE, cFGF-23, BNP, and proinflammatory markers were over the ranges of normality in both DM and non-DM groups. Only GA and sRAGE levels were increased in DM compared to non-DM patients. Plasma levels of sRAGE and CRP were the only independent predictors of BNP concentration. In conclusion, in DM CKD-G5D patients, sRAGE appeared to be a marker of cardiac remodeling. Indeed, its increase could be a potential protective mechanism against the increased risk of cardiovascular complications related to AGEs and inflammation. The causal relationship between sRAGE and cardiovascular risk in these patients needs to be further confirmed by mechanistic studies.

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Fibroblast growth factor-23 (FGF-23) as a prognostic marker for chronic kidney disease (CKD)

Science-Business eXchange ◽

10.1038/scibx.2011.726 ◽

2011 ◽

Vol 4 (25) ◽

pp. 726-726

Keyword(s):

Chronic Kidney Disease ◽

Growth Factor ◽

Kidney Disease ◽

Fibroblast Growth Factor ◽

Prognostic Marker ◽

Fibroblast Growth Factor 23 ◽

Fibroblast Growth ◽

Fgf 23

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MP594THE RELATIONSHIP BETWEEN FIBROBLAST GROWTH FACTOR-23 (FGF-23) AND SELECTED CLINICAL AND LABORATORY PARAMETERS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx177.mp594 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii648-iii649

Author(s):

Danuta Fedak ◽

Marek Kużniewski ◽

Marcin Krzanowski ◽

Paulina Dumnicka ◽

Wladyslaw Sulowicz

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Fibroblast Growth ◽

Laboratory Parameters ◽

Fgf 23

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SP287SERUM FIBROBLAST GROWTH FACTOR-23 (FGF-23), SOLUBLE KLOTHO (SKLOTHO) AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE (REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE)

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy104.sp287 ◽

2018 ◽

Vol 33 (suppl_1) ◽

pp. i440-i440

Author(s):

Elena Kozhevnikova ◽

Ludmila Milovanova ◽

Victor Fomin ◽

Yuriy Milovanov ◽

Vasiliy Kozlov ◽

...

Keyword(s):

Growth Factor ◽

Renal Disease ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Cardiovascular Complications ◽

Fibroblast Growth ◽

On Line ◽

End Stage ◽

Fgf 23 ◽

Regular Hemodialysis

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A Review of the Potential Application of Osteocyte-Related Biomarkers, Fibroblast Growth Factor-23, Sclerostin, and Dickkopf-1 in Predicting Osteoporosis and Fractures

Diagnostics ◽

10.3390/diagnostics10030145 ◽

2020 ◽

Vol 10 (3) ◽

pp. 145 ◽

Cited By ~ 1

Author(s):

Fitri Fareez Ramli ◽

Kok-Yong Chin

Keyword(s):

Growth Factor ◽

Fracture Risk ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Fracture Prediction ◽

Current Evidence ◽

Fibroblast Growth ◽

Osteoporosis Screening ◽

Potential Marker ◽

Dickkopf 1

Bone turnover markers (BTMs) derived from the secretory activities of osteoblasts and the matrix-degrading activities of osteoclasts are useful in monitoring the progression of osteoporosis and the efficacy of anti-osteoporotic treatment. However, the usefulness of BTMs in predicting osteoporosis remains elusive. Osteocytes play a central role in regulating bone formation and resorption. The proteins secreted by osteocytes, such as fibroblast growth factor-23 (FGF23), sclerostin (SOST), and dickkopf-1 (DKK1), could be candidates for osteoporosis screening and fracture prediction. This review summarizes the current evidence on the potential of osteocyte-related proteins as biomarkers for osteoporosis and fracture prediction. The literature reports that SOST may be a potential marker for osteoporosis screening but not for fracture prediction. FGF23 is a potential marker for increased fracture risk, but more studies are needed to confirm its usefulness. The role of DKK1 as a marker to predict osteoporosis and fracture risk cannot be confirmed due to a lack of consistent evidence. In conclusion, circulating osteocyte markers are potential osteoporosis biomarkers, but more studies are warranted to validate their clinical use.

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Fibroblast Growth Factor 23-Producing Phosphaturic Mesenchymal Tumor with Extraordinary Morphology Causing Oncogenic Osteomalacia

Medicina ◽

10.3390/medicina56010034 ◽

2020 ◽

Vol 56 (1) ◽

pp. 34

Author(s):

Cornelia Then ◽

Evelyn Asbach ◽

Harald Bartsch ◽

Niklas Thon ◽

Christian Betz ◽

...

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Olfactory Neuroblastoma ◽

Mesenchymal Tumor ◽

Fibroblast Growth ◽

Phosphaturic Mesenchymal Tumor ◽

Oncogenic Osteomalacia ◽

Pet Ct ◽

Fgf 23

A possible cause of hypophosphatemia is paraneoplastic secretion of fibroblast growth factor 23 (FGF-23). Tumors secreting FGF-23 are rare, mostly of mesenchymal origin, usually benign, and may be located anywhere in the body, including hands and feet, which are often not represented in conventional imaging. A 50-year-old woman presented with diffuse musculoskeletal pain and several fractures. Secondary causes of osteoporosis were excluded. Laboratory analysis revealed hypophosphatemia and elevated alkaline phosphatase, parathyroid hormone, and FGF-23. Thus, oncogenic osteomalacia due to neoplastic FGF-23 secretion was suspected. FDG-PET-CT and DOTATATE-PET-CT imaging demonstrated no tumor. Cranial MRI revealed a tumorous mass in the left cellulae ethmoidales. The tumor was resected and histopathological examination showed a cell-rich tumor with round to ovoid nuclei, sparse cytoplasm, and sparse matrix, resembling an olfactory neuroblastoma. Immunohistochemical analysis first led to diagnosis of olfactory neuroblastoma, which was later revised to phosphaturic mesenchymal tumor. Following the resection, FGF-23 and phosphate levels normalized. In conclusion, we here describe a patient with an FGF-23-secreting phosphaturic mesenchymal tumor with an unusual morphology. Furthermore, we emphasize diagnostic pitfalls when dealing with FGF-23-induced hypophosphatemia.

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Fibroblast growth factor-23 is associated with imaging markers of diabetic cardiomyopathy and anti-diabetic therapeutics

Cardiovascular Diabetology ◽

10.1186/s12933-020-01135-z ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Martin H. Sørensen ◽

Annemie S. Bojer ◽

Niklas R. Jørgensen ◽

David A. Broadbent ◽

Sven Plein ◽

...

Keyword(s):

Type 2 Diabetes ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Kidney Function ◽

Fibroblast Growth Factor 23 ◽

Left Ventricular ◽

Fibroblast Growth ◽

Cardiovascular Morbidity And Mortality ◽

Fgf 23

Abstract Background The biomarker fibroblast growth factor-23 (FGF-23) has been associated with increased cardiovascular morbidity and mortality in both patients with and without type 2 diabetes. The aim of this study was to evaluate the relationship between FGF-23 and cardiac structure, function and perfusion in patients with type 2 diabetes and normal or mildly impaired kidney function. Furthermore, to investigate the association between FGF-23, anti-diabetes therapy and the classic complications and risk factors associated with type 2 diabetes. Methods In this cross-sectional study, 246 patients with type 2 diabetes underwent echocardiography and advanced cardiac magnetic resonance imaging to assess left ventricular (LV) structure and function. In addition, myocardial blood flow (MBF) during rest and pharmacological stress (adenosine 140 µg/kg/min) were evaluated in 183 of the patients. Patients with eGFR < 60 ml/min/1.73 m2 were excluded. Results Median (Q1–Q3) FGF-23 was 74 (58–91) ng/L. Patients with FGF-23 above the median had lower MBF during stress (2.3 ± 0.9 vs. 2.7 ± 0.9 ml/min/g, P = 0.001) and lower overall myocardial perfusion reserve (MPR) (2.7 ± 0.8 vs. 3.3 ± 1.1, P < 0.001). LV mass (143 ± 40 vs. 138 ± 36 g, P = 0.04) and E/e* (8.5 ± 3.2 vs. 7.6 ± 2.7, P = 0.04) were higher in patients with FGF-23 above the median. In a linear model adjusted for age, sex, eGFR and hypertension, increasing FGF-23 was associated with decreased MPR (P < 0.01, R2 = 0.11) and increased E/e* (P < 0.01, R2 = 0.07). FGF-23 was lower in patients receiving glucagon like peptide-1 (GLP-1) analogues (71 (57–86) vs. 80 (60–98) ng/L, P = 0.01) than in those who did not receive GLP-1 analogues. Conclusions In patients with type 2 diabetes and normal or mildly impaired kidney function, increased levels of FGF-23 are associated with impaired cardiac diastolic function and decreased MPR, caused by a decrease in maximal MBF during stress. Use of GLP-1 analogues is associated with decreased levels of FGF-23. Clinical trial registrationhttps://www.clinicaltrials.gov. Unique identifier: NCT02684331. Date of registration: February 18, 2016

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Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study

International Journal of Molecular Sciences ◽

10.3390/ijms20092292 ◽

2019 ◽

Vol 20 (9) ◽

pp. 2292 ◽

Cited By ~ 1

Author(s):

Swati Gulati ◽

J. Michael Wells ◽

Gisel P. Urdaneta ◽

Kira Balestrini ◽

Isabel Vital ◽

...

Keyword(s):

Growth Factor ◽

Lung Function ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Airway Disease ◽

Cross Sectional Study ◽

Chronic Obstructive ◽

Fibroblast Growth ◽

Cross Sectional ◽

Fgf 23

Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory airway disease punctuated by exacerbations (AECOPD). Subjects with frequent AECOPD, defined by having at least two exacerbations per year, experience accelerated loss of lung function, deterioration in quality of life and increase in mortality. Fibroblast growth factor (FGF)23, a hormone associated with systemic inflammation and altered metabolism is elevated in COPD. However, associations between FGF23 and AECOPD are unknown. In this cross-sectional study, individuals with COPD were enrolled between June 2016 and December 2016. Plasma samples were analyzed for intact FGF23 levels. Logistic regression analyses were used to measure associations between clinical variables, FGF23, and the frequent exacerbator phenotype. Our results showed that FGF23 levels were higher in frequent exacerbators as compared to patients without frequent exacerbations. FGF23 was also independently associated with frequent exacerbations (OR 1.02; 95%CI 1.004–1.04; p = 0.017), after adjusting for age, lung function, smoking, and oxygen use. In summary, FGF23 was associated with the frequent exacerbator phenotype and correlated with number of exacerbations recorded retrospectively and prospectively. Further studies are needed to explore the role of FGF 23 as a possible biomarker for AECOPD to better understand the pathobiology of COPD and to help develop therapeutic targets.

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