Distribution and Effect of apo E Genotype on Plasma Lipid and Apolipoprotein Profiles in Overweight/Obese and Nonobese Chinese Subjects

Apolipoprotein E genotypes were measured in 83 patients with familial hypercholesterolaemia (FH) and in 175 blood donor controls. Following DNA extraction from peripheral blood, each sample was genotyped for the Apo E polymorphism by polymerase chain reaction. No significant differences were found in the levels of the ε2 and ε3 alleles between the two groups, while the ε4 allele was approximately twice as prevalent in the FH patients as in controls ( P = 0·006, df = 1). Of the FH patients, 8·4% were homozygous for the ε4 allele while this genotype was rare in controls ( P = 0·009, df = 1). These results suggest that the ε4 allele is over represented in the FH population and may contribute to increased cholesterol levels and consequent vascular disease.

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Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Stroke ◽

10.1161/str.32.suppl_1.321 ◽

2001 ◽

Vol 32 (suppl_1) ◽

pp. 321-321

Author(s):

Daniel Woo ◽

Laura Sauerbeck ◽

Brett M Kissela ◽

Jane C Khoury ◽

Rakesh Shukla ◽

...

Keyword(s):

Risk Factors ◽

Intracerebral Hemorrhage ◽

Environmental Risk ◽

Multivariable Analysis ◽

Population Based ◽

Environmental Risk Factors ◽

Degree Relative ◽

Increased Risk ◽

Apo E ◽

Apo E Genotype

27 Introduction: We report a planned midpoint analysis of a prospective, population-based, case-control study of the genetic and environmental risk factors of spontaneous, non-traumatic, intracerebral hemorrhage (ICH). Methods: Cases were matched to two controls by age, race and gender. Data was obtained by direct interview and review of all available medical and neuroimaging data. Apolipoprotein E (Apo E)genotype was determined by polymerase chain reaction. Multivariable analyses were performed using logistic regression modeling. Results: Between 6/97 and 2/00, 189 cases of ICH (150 white/39 black; 68 lobar/121 non-lobar) and 368 controls were enrolled into the study. Independent risk factors for multivariable analysis are listed in the table. Only prior stroke was an independent risk factor for both lobar and non-lobar ICH. Conclusions: The importance of individual genetic and environmental risk factors for ICH vary substantially by location of ICH. A history of a first-degree relative with ICH was associated with an increased risk of lobar ICH, independent of Apo E genotype. This finding indicates that other genetic risk factors may be important in the development of ICH.

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Apolipoprotein E, Cognitive Function, and Dementia in a General Population Aged 85 Years and Over

International Psychogeriatrics ◽

10.1017/s1041610200006487 ◽

2000 ◽

Vol 12 (3) ◽

pp. 379-387 ◽

Cited By ~ 15

Author(s):

Kati Juva ◽

Auli Verkkoniemi ◽

Petteri Viramo ◽

Tuomo Polvikoski ◽

Katariina Kainulainen ◽

...

Keyword(s):

Mini Mental State Examination ◽

Mmse Score ◽

Reference Population ◽

Apo E ◽

Diagnosis Of Dementia ◽

Ε4 Allele ◽

Very Old Age ◽

The Mean ◽

Apo E Genotype ◽

State Examination

We examined 510 subjects representing 83.2% of all citizens of a Finnish city aged 85 years or over. Mini-Mental State Examination (MMSE) scores, diagnosis of dementia by DSM-III-R criteria, and Apo-E genotype were determined. The prevalence of dementia was 38.6%. The odds ratio (OR) of the Apo-E ε4 carriers (with the reference population of people with the genotype ε3/ε3) for dementia was 2.36 (95% CI 1.58–3.58). There was a significant sex difference: The OR in women was 3.23 (95% CI 2.02–5.17) whereas among men it was insignificant. The mean MMSE score (± SD) among the Apo-E ε4 carriers (15.0 ± 10.0) and noncarriers (18.7 ± 8.6) (p < .001) differed among the whole population, but not within the demented or nondemented subjects analyzed separately. This study does not support the hypothesis that the Apo-E ε4 allele impairs cognitive functions of nondemented elderly, at least in those surviving to very old age.

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Hypertriglyceridemia and Lower LDL Cholesterol Concentration in Relation to Apolipoprotein E Phenotypes in Myotonic Dystrophy

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100028675 ◽

1989 ◽

Vol 16 (1) ◽

pp. 129-133 ◽

Cited By ~ 8

Author(s):

Sital Moorjani ◽

Daniel Gaudet ◽

Claude Laberge ◽

Marie Christine Thibault ◽

Jean Mathieu ◽

...

Keyword(s):

Myotonic Dystrophy ◽

Ldl Cholesterol ◽

Plasma Cholesterol ◽

Plasma Lipid ◽

Cholesterol Concentration ◽

Plasma Triglycerides ◽

Ldl Particles ◽

Vldl Cholesterol ◽

Apo E

ABSTRACT:Plasma lipid, lipoprotein levels and apolipoprotein apo E phenotypes were determined in 70 patients with myotonic dystrophy (MyD) and 81 controls. Marked differences were noticed in the apo E phenotype frequencies between the two groups. Plasma triglycerides and VLDL cholesterol were higher in MyD than controls, but only the latter was related to differences in the apo E phenotypes between two groups. Accordingly, the ratio of VLDL cholesterol/plasma triglycerides was increased significantly in MyD, suggesting accumulation of intermediary density particles due to lower affinity of E2 containing lipoproteins for lipoprotein cell receptors. The LDL cholesterol concentration was lower in MyD than controls and was related to differences in the apo E phenotype frequencies between the two groups. These results indicate increased removal of LDL particles in the apo E2 phenotypes, perhaps due to upregulation of LDL (B, E) receptor activity. Plasma cholesterol and HDL cholesterol concentrations were similar in both groups. Another feature of the study was lower levels of plasma cholesterol, triglycerides, VLDL and LDL cholesterol in the homozygous E4:E4 phenotype. These results suggest increased clearance rate of both VLDL and LDL particles and support the concept that apo E4-containing lipoproteins have higher in vivo affinity for ape E and/or B, E receptors.

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The roles of apo E genotype, gender and adipokines in blood plasma lipids in Caucasians with well-controlled type 2 diabetes

International Journal of Diabetes and Metabolism ◽

10.1159/000497692 ◽

2010 ◽

Vol 18 (2) ◽

pp. 49-54

Author(s):

Douglas E. Barre D.E. ◽

Kazimiera A. Mizier-Barre K.A. ◽

Odette Griscti O. ◽

Kevin Hafez K.

Keyword(s):

Type 2 Diabetes ◽

Blood Plasma ◽

Plasma Lipids ◽

Apo E ◽

Apo E Genotype ◽

In Blood Plasma

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Emotional Responses to APO E Genotype Disclosure for Alzheimer Disease

Journal of Genetic Counseling ◽

10.1007/s10897-005-4063-1 ◽

2005 ◽

Vol 14 (2) ◽

pp. 141-150 ◽

Cited By ~ 15

Author(s):

Linda J. Romero ◽

Philip J. Garry ◽

Mark Schuyler ◽

David A. Bennahum ◽

Clifford Qualls ◽

...

Keyword(s):

Alzheimer Disease ◽

Emotional Responses ◽

Apo E ◽

Apo E Genotype

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Diets deficient in selenium and vitamin E affect plasma lipoprotein and apolipoprotein concentrations in the rat

British Journal Of Nutrition ◽

10.1079/bjn19960096 ◽

1996 ◽

Vol 76 (6) ◽

pp. 899-907 ◽

Cited By ~ 21

Author(s):

A Mazur ◽

F Nassir ◽

E Gueux ◽

C Moundras ◽

J Bellanger ◽

...

Keyword(s):

Vitamin E ◽

Plasma Cholesterol ◽

Plasma Lipid ◽

Lipoprotein Metabolism ◽

Plasma Lipoprotein ◽

Vitamin E Deficiency ◽

Apo B ◽

Apo E ◽

Se Deficiency

The present study examined the effects of Se, vitamin E and combined Se and vitamin E deficiencies in rats on plasma lipid, Lipoprotein and apolipoprotein (apo) concentrations. Deficiencies were induced by feeding rats the respective diets for 6 weeks. The study shows that Se deficiency results in increased concentrations of plasma cholesterol and apo E. Both could be explained by an increase in the HDL1 fraction. Vitamin E deficiency alone had no significant effect on plasma lipid, lipoprotein and apo concentrations. Se deficiency in combination with vitamin E deficiency leads to an increase in plasma LDL and apo B concentrations. These results point to the need for further investigations on the mechanism by which Se deficiency affects lipoprotein metabolism.

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