Cytotoxicity induced by inhibition of thioredoxin reductases via multiple signaling pathways: Role of cytosolic phospholipase A2α-dependent and -independent release of arachidonic acid

2009 ◽  
Vol 219 (3) ◽  
pp. 606-616 ◽  
Author(s):  
Takeshi Kurosawa ◽  
Hiroyuki Nakamura ◽  
Erika Yamaura ◽  
Hiromichi Fujino ◽  
Yasuo Matsuzawa ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Signaling Pathways ◽  
Cytosolic Phospholipase ◽  
Cytosolic Phospholipase A2α ◽  
Thioredoxin Reductases ◽  
Multiple Signaling

Inhibitory role of oleanolic acid and esculetin in HeLa cells involve multiple signaling pathways

Gene ◽  
2021 ◽  
Vol 771 ◽  
pp. 145370
Author(s):  
Prajitha Mohandas Edathara ◽  
Shivakanth Chintalapally ◽  
Venkata Krishna Kanth Makani ◽  
Chitrakshi Pant ◽  
Suresh Yerramsetty ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Hela Cells ◽  
Inhibitory Role ◽  
Multiple Signaling

scholarly journals Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

2003 ◽  
Vol 197 (10) ◽  
pp. 1297-1302 ◽  
Author(s):  
Martin Hegen ◽  
Linhong Sun ◽  
Naonori Uozumi ◽  
Kazuhiko Kume ◽  
Mary E. Goad ◽  
...  
Keyword(s):  
Critical Role ◽  
Wild Type ◽  
Collagen Induced Arthritis ◽  
Cytosolic Phospholipase ◽  
Severity Scores ◽  
In The Wild ◽  
Cytosolic Phospholipase A2α ◽  
Antibody Levels ◽  
Deficient Mice

Pathogenic mechanisms relevant to rheumatoid arthritis occur in the mouse model of collagen-induced arthritis (CIA). Cytosolic phospholipase A2α (cPLA2α) releases arachidonic acid from cell membranes to initiate the production of prostaglandins and leukotrienes. These inflammatory mediators have been implicated in the development of CIA. To test the hypothesis that cPLA2α plays a key role in the development of CIA, we backcrossed cPLA2α-deficient mice on the DBA/1LacJ background that is susceptible to CIA. The disease severity scores and the incidence of disease were markedly reduced in cPLA2α-deficient mice compared with wild-type littermates. At completion of the study, >90% of the wild-type mice had developed disease whereas none of the cPLA2α-deficient mice had more than one digit inflamed. Furthermore, visual disease scores correlated with severity of disease determined histologically. Pannus formation, articular fibrillation, and ankylosis were all dramatically reduced in the cPLA2α-deficient mice. Although the disease scores differed significantly between cPLA2α mutant and wild-type mice, anti-collagen antibody levels were similar in the wild-type mice and mutant littermates. These data demonstrate the critical role of cPLA2α in the pathogenesis of CIA.

Inhibition of arachidonic acid release and cytosolic phospholipase A2α activity by d-erythro-sphingosine

2004 ◽  
Vol 484 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Hiroyuki Nakamura ◽  
Testuya Hirabayashi ◽  
Akiyoshi Someya ◽  
Masaya Shimizu ◽  
Toshihiko Murayama
Keyword(s):  
Arachidonic Acid ◽  
Arachidonic Acid Release ◽  
Cytosolic Phospholipase ◽  
Acid Release ◽  
Cytosolic Phospholipase A2α
Sign in / Sign up

Export Citation Format

Share Document