Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study

2018 ◽  
Vol 234 (8) ◽  
pp. 12934-12940 ◽  
Author(s):  
Rostam Maruei‐Milan ◽  
Zahra Heidari ◽  
Saeedeh Salimi

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109822 ◽  
Author(s):  
Marina Santos ◽  
Teresa Azevedo ◽  
Teresa Martins ◽  
Fernando J. Rodrigues ◽  
Manuel C. Lemos


Author(s):  
Ayman A Zayed ◽  
Justin Z Amarin ◽  
Abdallah T Al-Ani ◽  
Tareq L Altell ◽  
Sultan S Abdelhamid ◽  
...  

Abstract Context Papillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many genetic disorders. Objective This work aimed to investigate the association of parental consanguinity with PTC. Methods This case-control study of PTC patients compared with healthy controls took place in a tertiary referral hospital. We recruited 200 PTC patients who were managed at the endocrinology outpatient clinics of the Jordan University Hospital, and we recruited 515 healthy controls from a nonclinical setting. We interviewed all participants and collected sociodemographic data. We reviewed the family pedigrees of each participant four generations back and excluded any participant who was related. We established whether the parents of each participant were first cousins, first cousins once removed, second cousins, or unrelated. We then used binary logistic regression to assess the association of parental consanguinity with PTC adjusted for age, sex, smoking status, body mass index, and parental education. Results We recruited 715 participants. The numbers of PTC patients and healthy controls were 200 (28.0%) and 515 (72.0%), respectively. The rate of parental consanguinity was 25.5% in PTC patients and 12.2% in healthy controls. Parental consanguinity was significantly associated with PTC (adjusted odds ratio, 2.60; 95% CI, 1.63-4.17; P < .001). Conclusion Parental consanguinity is a risk factor for PTC. Our findings should be considered during familial risk assessment and genetic counseling, especially in populations with high rates of consanguinity.



2017 ◽  
Vol 42 (5) ◽  
pp. 1424-1431 ◽  
Author(s):  
Joon-Hyop Lee ◽  
Ra-Yeong Song ◽  
Jin Wook Yi ◽  
Hyeong Won Yu ◽  
Hyungju Kwon ◽  
...  


Cancer ◽  
1988 ◽  
Vol 62 (7) ◽  
pp. 1381-1388 ◽  
Author(s):  
Steven A. Smith ◽  
Ian D. Hay ◽  
John R. Goellner ◽  
John J. Ryan ◽  
William M. McConahey






2018 ◽  
Vol 11 (3) ◽  
Author(s):  
Samaneh Famil Sagharchian ◽  
Mahdi Hedayati ◽  
Faranak Kazerouni ◽  
Ali Rahimipour ◽  
Mehrnoosh Shanaki


2016 ◽  
Vol 77 (4) ◽  
pp. 262
Author(s):  
P. Pigny ◽  
M. Crépin ◽  
C. Do Cao ◽  
J.L. Wemeau ◽  
C. Cardot Bauters ◽  
...  


2018 ◽  
Author(s):  
Adina Anghel ◽  
Gabriela Vasiliu ◽  
Maria Christina Ungureanu ◽  
Cristina Preda ◽  
Voichita Mogos ◽  
...  


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