Myosteatosis as an independent risk factor for mortality after kidney allograft transplantation: a retrospective cohort study

Objective To explore whether thin endometrial thickness (EMT) is associated with singleton low birth weight (LBW) from single fresh blastocyst transfer. Design Retrospective cohort study. Setting Reproductive center. Population All women were ≤40 years old and underwent single fresh blastocyst transfer and singleton live birth. Interventions None. Methods Multivariable logistic regression was used to evaluate the association between thin EMT and singleton LBW. Main outcome measures LBW was the primary concern of this study. Results In total, 2847 women met the study inclusion criteria. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm group (P<0.001). The rate of LBW in the EMT ≤7.5 mm group was 24.9%, which was significantly higher than the 4.0% in the EMT 7.6~12.0 mm group and the 5.3% in the EMT >12.0 mm group (P<0.001). The total neonatal malformation rate was similar between the groups (1.1%, 0.8% and 1.5%, P=0.21). After multiple logistic regression analysis, EMT≤7.5 mm was an independent risk factor for LBW (adjusted odds ratio [AOR]: 4.39, 95% CI: 1.85～10.46, P<0.001). Conclusions Thin EMT (≤7.5 mm) on the hCG trigger day is an independent risk factor for singleton LBW from single fresh blastocyst transfer. The neonatal birthweight in the EMT ≤7.5 mm group was significantly lower than that in the EMT 7.6~12.0 mm and EMT >12.0 mm groups. The total neonatal malformation rate was comparable between the groups.

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Incidence of Heart Failure among Diabetic Patients with Ischemic Heart Disease: A Cohort Study

10.21203/rs.2.12559/v2 ◽

2020 ◽

Author(s):

Senbeta Guteta Abdissa ◽

Wakgari Deressa ◽

Amit J Shah

Keyword(s):

Diabetes Mellitus ◽

Heart Failure ◽

Risk Factor ◽

Cohort Study ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Independent Risk Factor ◽

Ischemic Heart

Abstract Background: In population studies of heart failure (HF), diabetes mellitus (DM) has been shown to be an independent risk factor. However, the evidence evaluating it as an independent risk factor in incident HF in patients with ischemic heart disease (IHD) is scarce. Our study aimed to assess the incidence of HF in diabetic IHD patients compared to non-diabetic IHD patients in Ethiopia. Methods: A retrospective cohort study was conducted among 306 patients with IHD followed-up at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia. The IHD patients who did not have HF at baseline were followed for 24 months beginning from November 30, 2015. We assessed the incidence of HF in patients with diabetic IHD versus the non-diabetic IHD. Cox proportional hazards models were used to assess the association between diabetic IHD and HF after controlling for important covariates. Hypertension was examined as a possible effect modifier as well. Results: The mean age was 56.8 years, 69% were male, and 31% were diabetic. During the 24 months follow-up period, 196 (64.1%) had incident HF. On multivariate Cox regression, DM was significantly associated with incident HF [Hazard Ratio = 2.04, 95% confidence interval (CI): 1.32-3.14, p = 0.001]. Furthermore, when the patients were stratified by hypertension (HTN) status, DM was associated with worse prognosis, and the strongest association was in those with co-existing DM and HTN [HR = 2.57,95% CI =1.66-3.98, p<0.0001], followed by the presence of DM without HTN [HR 2.27, 95% CI = 1.38-3.71, p=0.001] (compared to those with neither). Conclusion: DM is the strongest predictor of incident HF, compared to other traditional risk factors, in Ethiopian patients with IHD. Those with both DM and HTN are at the highest risk. Key Words: Ischemic heart disease; Heart failure; Incidence; Diabetes Mellitus; Retrospective cohort study

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Autoimmune Hemolytic Anemia Confers an Independent Risk Factor for Thrombosis: Retrospective Cohort Study Using the “STRIDE” Database

Annals of Hematology & Oncology ◽

10.26420/annhematoloncol.2017.1160 ◽

2017 ◽

Vol 4 (7) ◽

Author(s):

Shivaani Kummar

Keyword(s):

Risk Factor ◽

Cohort Study ◽

Hemolytic Anemia ◽

Retrospective Cohort Study ◽

Autoimmune Hemolytic Anemia ◽

Retrospective Cohort ◽

Independent Risk Factor

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Cardiopulmonary bypass time is an independent risk factor for acute kidney injury in emergent thoracic aortic surgery: a retrospective cohort study

Journal of Cardiothoracic Surgery ◽

10.1186/s13019-019-0907-x ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 9

Author(s):

Shijun Xu ◽

Jie Liu ◽

Lei Li ◽

Zining Wu ◽

Jiachen Li ◽

...

Keyword(s):

Acute Kidney Injury ◽

Risk Factor ◽

Cohort Study ◽

Cardiopulmonary Bypass ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Independent Risk Factor ◽

Aortic Surgery ◽

Kidney Injury ◽

Thoracic Aortic Surgery

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Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study

Journal of Intensive Care Medicine ◽

10.1177/08850666211005422 ◽

2021 ◽

pp. 088506662110054

Author(s):

Kevin Ho ◽

Joshua Gordon ◽

Kevin T. Litzenberg ◽

Matthew C. Exline ◽

Joshua A. Englert ◽

...

Keyword(s):

Risk Factor ◽

Acute Respiratory Distress Syndrome ◽

Cohort Study ◽

Critically Ill ◽

Retrospective Cohort Study ◽

Critically Ill Patients ◽

Retrospective Cohort ◽

Independent Risk Factor ◽

Distress Syndrome ◽

Single Center

Background: Acute Respiratory Distress Syndrome (ARDS) is a frequent cause of respiratory failure in intensive care unit (ICU) patients and results in significant morbidity and mortality. ARDS often develops as a result of a local or systemic inflammatory insult. Cancer can lead to systemic inflammation but whether cancer is an independent risk factor for developing ARDS is unknown. We hypothesized that critically ill cancer patients admitted to the ICU were at increased risk for the diagnosis of ARDS. Methods: Retrospective cohort study of critically ill patients admitted between July 2017 and December 2018 at an academic medical center in Columbus, Ohio. The primary outcome was the association of patients with malignancy and the diagnosis of ARDS in a multivariable logistic regression model with covariables selected a priori informed through the construction of a directed acyclic graph. Results: 412 ARDS cases were identified with 166 of those patients having active cancer. There was an association between cancer and ARDS, with an odds ratio (OR) of 1.55 (95% CI 1.26-1.92, P < 0.001). When adjusted for our pre-specified confounding variables, the association remained statistically significant (OR 1.57, 95% CI 1.15-2.13, P = 0.004). In an unadjusted pre-specified subgroup analysis, hematologic malignancy (OR 1.81, 95% CI 1.30-2.53, P < 0.001) was associated with increased odds of developing ARDS while non-metastatic solid tumors (OR 0.51, 95% CI 0.31-0.85, P = 0.01) had statistically significant negative association. Cancer patients with ARDS had a significantly higher ICU (70.5% vs 39.8%, P < 0.001) and hospital (72.9% vs 40.7%, P < 0.001) mortality compared to ARDS patients without active malignancy. Conclusion: In this single center retrospective cohort study, cancer was found to be an independent risk factor for the diagnosis of ARDS in critically ill patients. To our knowledge, we are the first report an independent association between cancer and ARDS in critically ill patients.

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