Age‐dependent cerebrospinal fluid‐tissue water exchange detected by magnetization transfer indirect spin labeling MRI

2021 ◽  
Author(s):  
Anna M. Li ◽  
Lin Chen ◽  
Hongshuai Liu ◽  
Yuguo Li ◽  
Wenzhen Duan ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Water Exchange ◽  
Magnetization Transfer ◽  
Spin Labeling ◽  
Tissue Water ◽  
Age Dependent

Age-Dependent Decline in the Apolipoprotein E Level in Cerebrospinal Fluid from Control Subjects and Its Increase in Cerebrospinal Fluid from Patients with Alzheimer’s Disease

2000 ◽  
Vol 43 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Ryuichi Fukuyama ◽  
Toshiki Mizuno ◽  
Satoru Mori ◽  
Katsuhiko Yanagisawa ◽  
Kenji Nakajima ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Control Subjects ◽  
Age Dependent

Water Exchange in the Brain and Cerebrospinal Fluid

1954 ◽  
Vol 11 (3) ◽  
pp. 234-242 ◽  
Author(s):  
Edgar A. Bering
Keyword(s):  
Cerebrospinal Fluid ◽  
Water Exchange ◽  
The Brain

Embryonic Neural Cell Adhesion Molecule in Cerebrospinal Fluid of Younger Children: Age-Dependent Decrease During the First Year

1990 ◽  
Vol 55 (6) ◽  
pp. 2063-2071 ◽  
Author(s):  
Ch. Weisgerber ◽  
M. Husmann ◽  
M. Frosch ◽  
C. Rheinheimer ◽  
W. Peuckert ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
First Year ◽  
Neural Cell Adhesion ◽  
Age Dependent

scholarly journals Removal of cerebrospinal fluid partial volume effects in quantitative magnetization transfer imaging using a three-pool model with nonexchanging water component

2014 ◽  
Vol 74 (5) ◽  
pp. 1317-1326 ◽  
Author(s):  
Pouria Mossahebi ◽  
Andrew L. Alexander ◽  
Aaron S. Field ◽  
Alexey A. Samsonov
Keyword(s):  
Cerebrospinal Fluid ◽  
Magnetization Transfer ◽  
Magnetization Transfer Imaging ◽  
Partial Volume ◽  
Partial Volume Effects ◽  
Pool Model ◽  
Volume Effects

scholarly journals Two Mass-Spectrometric Techniques for Quantifying Serine Enantiomers and Glycine in Cerebrospinal Fluid: Potential Confounders and Age-Dependent Ranges

2008 ◽  
Vol 54 (9) ◽  
pp. 1443-1450 ◽  
Author(s):  
Sabine A Fuchs ◽  
Monique G M de Sain-van der Velden ◽  
Martina M J de Barse ◽  
Martin W Roeleveld ◽  
Margriet Hendriks ◽  
...  
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Biological Fluids ◽  
Nervous System Development ◽  
High Throughput Analysis ◽  
Analysis Techniques ◽  
Deming Regression ◽  
Age Dependent

Abstract Background: The recent discovery and specific functions of d-amino acids in humans are bound to lead to the revelation of d-amino acid abnormalities in human disorders. Therefore, high-throughput analysis techniques are warranted to determine d-amino acids in biological fluids in a routine laboratory setting. Methods: We developed 2 chromatographic techniques, a nonchiral derivatization with chiral (chirasil-l-val column) separation in a GC-MS system and a chiral derivatization with Marfey’s reagent and LC- MS analysis. We validated the techniques for d-serine, l-serine, and glycine determination in cerebrospinal fluid (CSF), evaluated several confounders, and determined age-dependent human concentration ranges. Results: Quantification limits for d-serine, l-serine, and glycine in cerebrospinal fluid were 0.14, 0.44, and 0.14 μmol/L, respectively, for GC-MS and 0.20, 0.41, and 0.14 μmol/L for LC-MS. Within-run imprecision was <3% for both methods, and between-run imprecision was <13%. Comparison of both techniques with Deming regression yielded coefficients of 0.90 (d-serine), 0.92 (l-serine), and 0.96 (glycine). Sample collection, handling, and transport is uncomplicated—there is no rostrocaudal CSF gradient, no effect of storage at 4 °C for 1 week before storage at −80 °C, and no effect of up to 3 freeze/thaw cycles. Conversely, contamination with erythrocytes increased d-serine, l-serine, and glycine concentrations. CSF concentrations for 145 apparently healthy controls demonstrated markedly and specifically increased (5 to 9 times) d-serine concentrations during early central nervous system development. Conclusions: These 2 clinically applicable analysis techniques will help to unravel pathophysiologic, diagnostic, and therapeutic issues for disorders associated with central nervous system abnormalities, NMDA-receptor dysfunction, and other pathology associated with d-amino acids.

Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis

2006 ◽  
Vol 250 (1-2) ◽  
pp. 50-57 ◽  
Author(s):  
Sandra Ebert ◽  
David J. Phillips ◽  
Peter Jenzewski ◽  
Roland Nau ◽  
Anne E. O'Connor ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Activin A ◽  
Human Cerebrospinal Fluid ◽  
Age Dependent

scholarly journals Two-Compartment Exchange Model for Perfusion Quantification Using Arterial Spin Tagging

2001 ◽  
Vol 21 (4) ◽  
pp. 440-455 ◽  
Author(s):  
Jinyuan Zhou ◽  
David A. Wilson ◽  
John A. Ulatowski ◽  
Richard J. Traystman ◽  
Peter C. M. van Zijl
Keyword(s):  
Signal Intensity ◽  
Water Exchange ◽  
Compartment Model ◽  
Intensity Difference ◽  
Tissue Water ◽  
Spin Tagging ◽  
Tissue Space ◽  
Perfusion Quantification ◽  
The Individual ◽  
Limited Water Exchange

The original well-mixed tissue model for the arterial spin tagging techniques is extended to a two-compartment model of restricted water exchange between microvascular (blood) and extravascular (tissue) space in the parenchyma. The microvascular compartment consists of arterioles, capillaries, and venules, with the blood/tissue water exchange taking place in the capillaries. It is shown that, in the case of limited water exchange, the individual FAIR (Flow-sensitive Alternating Inversion Recovery) signal intensities of the two compartments are comparable in magnitude, but are not overlapped in time. It is shown that when the limited water exchange is assumed to be fast, flows quantified from the signal-intensity difference are underestimated, an effect that becomes more significant for larger flows and higher magnetic field strengths. Experimental results on cat brain at 4.7 T comparing flow data from the FAIR signal-intensity difference with those from microspheres over a cerebral blood flow range from 15 to 150 mL 100 g−1 min−1 confirm these theoretic predictions. FAIR flow values with correction for restricted exchange, however, correlate well with the radioactive microsphere flow values. The limitations of the approach in terms of choice of the intercompartmental exchange rates are discussed.

P2-369: MEASURING WATER EXCHANGE ACROSS BLOOD BRAIN BARRIER IN ELDERLY SUBJECTS BY DIFFUSION WEIGHTED PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING

2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P835-P836 ◽  
Author(s):  
Xingfeng Shao ◽  
Samantha J. Ma ◽  
Lei Cao ◽  
Marlene Casey ◽  
John M. Ringman ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Arterial Spin Labeling ◽  
Water Exchange ◽  
Spin Labeling ◽  
Brain Barrier ◽  
Elderly Subjects ◽  
Blood Brain ◽  
Diffusion Weighted ◽  
Continuous Arterial Spin Labeling
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