scholarly journals Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution

Obesity ◽  
2021 ◽  
Vol 29 (3) ◽  
pp. 550-561
Author(s):  
Josiane L. Broussard ◽  
Leigh Perreault ◽  
Emily Macias ◽  
Sean A. Newsom ◽  
Kathleen Harrison ◽  
...  
Keyword(s):  
Sex Differences ◽  
Insulin Sensitivity ◽  
Muscle Tissue ◽  
Lipid Distribution

Sex Differences in Insulin Sensitivity Are Related to Muscle Tissue Acylcarnitines and Serum Lysophosphatidylcholines but Not Subcellular Lipid Distribution in Humans

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 158-OR
Author(s):  
JOSIANE L. BROUSSARD ◽  
LEIGH PERREAULT ◽  
SEAN A. NEWSOM ◽  
DARCY E. KAHN ◽  
ANNA KEREGE ◽  
...  
Keyword(s):  
Sex Differences ◽  
Insulin Sensitivity ◽  
Muscle Tissue ◽  
Lipid Distribution

scholarly journals Sex-Related Differences in the Effects of the Mediterranean Diet on Glucose and Insulin Homeostasis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Alexandra Bédard ◽  
Louise Corneau ◽  
Benoît Lamarche ◽  
Sylvie Dodin ◽  
Simone Lemieux
Keyword(s):  
Sex Differences ◽  
Insulin Sensitivity ◽  
Mediterranean Diet ◽  
Sex Difference ◽  
Premenopausal Women ◽  
Nonesterified Fatty Acids ◽  
Time Interaction ◽  
Insulin Homeostasis ◽  
The Mediterranean ◽  
The Impact

Objective. To document sex differences in the impact of the Mediterranean diet (MedDiet) on glucose/insulin homeostasis and to verify whether these sex-related effects were associated with changes in nonesterified fatty acids (NEFA).Methods. All foods were provided to 38 men and 32 premenopausal women (24–53 y) during 4 weeks. Variables were measured during a 180 min OGTT before and after the MedDiet.Results. A sex-by-time interaction for plasma insulin iAUC was found (men: −17.8%,P=0.02; women: +9.4%,P=0.63;Pfor sex-by-time interaction = 0.005). A sex-by-time interaction was also observed for insulin sensitivity (Cederholm index,P=0.03), for which only men experienced improvements (men: +8.1%,P=0.047; women: −5.9%,P=0.94). No sex difference was observed for glucose and C-peptide responses. Trends toward a decrease in NEFA AUC (P=0.06) and an increase in NEFA suppression rate (P=0.06) were noted, with no sex difference. Changes in NEFA were not associated with change in insulin sensitivity.Conclusions. Results suggest that the more favorable changes in glucose/insulin homeostasis observed in men compared to women in response to the MedDiet are not explained by sex differences in NEFA response. This clinical trial is registered with clinicaltrials.govNCT01293344.

Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity

Metabolism ◽  
2012 ◽  
Vol 61 (8) ◽  
pp. 1108-1117 ◽  
Author(s):  
Emilia Amengual-Cladera ◽  
Isabel Lladó ◽  
Magdalena Gianotti ◽  
Ana M. Proenza
Keyword(s):  
Sex Differences ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
White Adipose Tissue ◽  
Mitochondrial Function ◽  
High Fat Diet ◽  
High Fat

Sex differences in insulin sensitivity and insulin response with increasing age in black South African men and women

2016 ◽  
Vol 122 ◽  
pp. 207-214 ◽  
Author(s):  
Julia H. Goedecke ◽  
Cindy George ◽  
Katherine Veras ◽  
Nasheeta Peer ◽  
Carl Lombard ◽  
...  
Keyword(s):  
Sex Differences ◽  
Insulin Sensitivity ◽  
South African ◽  
Insulin Response ◽  
Men And Women ◽  
Black South African

scholarly journals Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction

2017 ◽  
Vol 313 (4) ◽  
pp. E402-E412 ◽  
Author(s):  
Nathan C. Winn ◽  
Zachary I. Grunewald ◽  
Michelle L. Gastecki ◽  
Makenzie L. Woodford ◽  
Rebecca J. Welly ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sex Differences ◽  
Insulin Sensitivity ◽  
Ex Vivo ◽  
Uncoupling Protein ◽  
Liver Steatosis ◽  
Radical Scavenger ◽  
Metabolic Dysfunction ◽  
Vasomotor Function ◽  
Brown Adipose

Females are typically more insulin sensitive than males, which may be partly attributed to greater brown adipose tissue (BAT) activity and uncoupling protein 1 (UCP1) content. Accordingly, we tested the hypothesis that UCP1 deletion would abolish sex differences in insulin sensitivity and that whitening of thoracic periaortic BAT caused by UCP1 loss would be accompanied with impaired thoracic aortic function. Furthermore, because UCP1 exerts antioxidant effects, we examined whether UCP1 deficiency-induced metabolic dysfunction was mediated by oxidative stress. Compared with males, female mice had lower HOMA- and AT-insulin resistance (IR) despite no significant differences in BAT UCP1 content. UCP1 ablation increased HOMA-IR, AT-IR, and whitening of BAT in both sexes. Expression of UCP1 in thoracic aorta was greater in wild-type females compared with males. Importantly, deletion of UCP1 enhanced aortic vasomotor function in females only. UCP1 ablation did not promote oxidative stress in interscapular BAT. Furthermore, daily administration of the free radical scavenger tempol for 8 wk did not abrogate UCP1 deficiency-induced increases in adiposity, hyperinsulinemia, or liver steatosis. Collectively, we report that 1) in normal chow-fed mice housed at 25°C, aortic UCP1 content was greater in females than males and its deletion improved ex vivo aortic vasomotor function in females only; 2) constitutive UCP1 content in BAT was similar between females and males and loss of UCP1 did not abolish sex differences in insulin sensitivity; and 3) the metabolic disruptions caused by UCP1 ablation did not appear to be contingent upon increased oxidative stress in mice under normal dietary conditions.

Adipocytes and lipid distribution in the muscle tissue of Atlantic salmon (Salmo salar)

1996 ◽  
Vol 53 (2) ◽  
pp. 326-332 ◽  
Author(s):  
Shengying Zhou ◽  
Robert G Ackman ◽  
Carol Morrison
Keyword(s):  
Atlantic Salmon ◽  
Salmo Salar ◽  
Muscle Tissue ◽  
Atlantic Salmon Salmo Salar ◽  
Lipid Distribution

scholarly journals Insulin sensitivity in critically ill patients: are women more insulin resistant?

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vincent Uyttendaele ◽  
J. Geoffrey Chase ◽  
Jennifer L. Knopp ◽  
Rebecca Gottlieb ◽  
Geoffrey M. Shaw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Sex Differences ◽  
Insulin Sensitivity ◽  
Metabolic Response ◽  
Demographic Data ◽  
Randomised Trial ◽  
Preterm Neonates ◽  
Men And Women ◽  
Increased Risk ◽  
Significant Difference

Abstract Background Glycaemic control (GC) in intensive care unit is challenging due to significant inter- and intra-patient variability, leading to increased risk of hypoglycaemia. Recent work showed higher insulin resistance in female preterm neonates. This study aims to determine if there are differences in inter- and intra-patient metabolic variability between sexes in adults, to gain in insight into any differences in metabolic response to injury. Any significant difference would suggest GC and randomised trial design should consider sex differences to personalise care. Methods Insulin sensitivity (SI) levels and variability are identified from retrospective clinical data for men and women. Data are divided using 6-h blocks to capture metabolic evolution over time. In total, 91 male and 54 female patient GC episodes of minimum 24 h are analysed. Hypothesis testing is used to determine whether differences are significant (P < 0.05), and equivalence testing is used to assess whether these differences can be considered equivalent at a clinical level. Data are assessed for the raw cohort and in 100 Monte Carlo simulations analyses where the number of men and women are equal. Results Demographic data between females and males were all similar, including GC outcomes (safety from hypoglycaemia and high (> 50%) time in target band). Females had consistently significantly lower SI levels than males, and this difference was not clinically equivalent. However, metabolic variability between sexes was never significantly different and always clinically equivalent. Thus, inter-patient variability was significantly different between males and females, but intra-patient variability was equivalent. Conclusion Given equivalent intra-patient variability and significantly greater insulin resistance, females can receive the same benefit from safe, effective GC as males, but may require higher insulin doses to achieve the same glycaemia. Clinical trials should consider sex differences in protocol design and outcome analyses.

Myofibrillar distribution of succinate dehydrogenase activity and lipid stores differs in skeletal muscle tissue of paraplegic subjects

2012 ◽  
Vol 302 (3) ◽  
pp. E365-E373 ◽  
Author(s):  
Richard A. M. Jonkers ◽  
Marlou L. Dirks ◽  
Christine I. H. C. Nabuurs ◽  
Henk M. De Feyter ◽  
Stephan F. E. Praet ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Succinate Dehydrogenase ◽  
Muscle Tissue ◽  
Muscle Fiber ◽  
Muscle Fibers ◽  
Oxidative Capacity ◽  
Skeletal Muscle Tissue ◽  
Whole Body ◽  
The Impact

Lack of physical activity has been related to an increased risk of developing insulin resistance. This study aimed to assess the impact of chronic muscle deconditioning on whole body insulin sensitivity, muscle oxidative capacity, and intramyocellular lipid (IMCL) content in subjects with paraplegia. Nine subjects with paraplegia and nine able-bodied, lean controls were recruited. An oral glucose tolerance test was performed to assess whole body insulin sensitivity. IMCL content was determined both in vivo and in vitro using1H-magnetic resonance spectroscopy and fluorescence microscopy, respectively. Muscle biopsy samples were stained for succinate dehydrogenase (SDH) activity to measure muscle fiber oxidative capacity. Subcellular distributions of IMCL and SDH activity were determined by defining subsarcolemmal and intermyofibrillar areas on histological samples. SDH activity was 57 ± 14% lower in muscle fibers derived from subjects with paraplegia when compared with controls ( P < 0.05), but IMCL content and whole body insulin sensitivity did not differ between groups. In muscle fibers taken from controls, both SDH activity and IMCL content were higher in the subsarcolemmal region than in the intermyofibrillar area. This typical subcellular SDH and IMCL distribution pattern was lost in muscle fibers collected from subjects with paraplegia and had changed toward a more uniform distribution. In conclusion, the lower metabolic demand in deconditioned muscle of subjects with paraplegia results in a significant decline in muscle fiber oxidative capacity and is accompanied by changes in the subcellular distribution patterns of SDH activity and IMCL. However, loss of muscle activity due to paraplegia is not associated with substantial lipid accumulation in skeletal muscle tissue.

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