Dereplication of phenolic derivatives of three Erythroxylum species using liquid chromatography coupled with ESI‐MS n and HRESIMS

2021 ◽  
Author(s):  
César Augusto Gonçalves Dantas ◽  
Lucas Silva Abreu ◽  
Hidna Nascimento Cunha ◽  
Carlos Arthur Gouveia Veloso ◽  
Augusto Lopes Souto ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Esi Ms ◽  
Phenolic Derivatives ◽  
Derivatives Of

Multi-alkylated Polynuclear Aromatic Hydrocarbons of Tobacco Smoke: Separation and Identification

1978 ◽  
Vol 9 (4) ◽  
Author(s):  
M. E. Snook ◽  
R. F. Severson ◽  
R. F. Arrendale ◽  
H. C. Higman ◽  
O. T. Chortyk
Keyword(s):  
Liquid Chromatography ◽  
Cigarette Smoke ◽  
Aromatic Hydrocarbons ◽  
Ultra Violet ◽  
Polynuclear Aromatic Hydrocarbons ◽  
Gel Chromatography ◽  
Cigarette Smoke Condensate ◽  
Gas And Liquid Chromatography ◽  
Silicic Acid Chromatography ◽  
Derivatives Of

AbstractThe methyl, multi-methyl, and ethyl derivatives of the polynuclear aromatic hydrocarbons (PAH) of cigarette smoke condensate (CSC) were isolated from the neutrals by silicic acid chromatography, solvent partitioning and gel chromatography. The procedure yielded a relatively pure PAH isolate amenable to further identifications. The multi-alkylated PAH were concentrated in the early gel fractions with parent and higher ring PAH found in subsequent gel fractions. It was shown that CSC is very rich in alkylated PAH, and their successful identification required extensive use of gas and liquid chromatography and ultra-violet and GC - mass spectrometric techniques. High-pressure liquid chromatography (HPLC) separated individual isomers of the alkylated PAH in complex GC peaks. PAH from indene to pentamethylchrysene were found. This report concludes our identification studies on the PAH of CSC and complements our two previous reports in this journal. Collectively, our studies have identified approximately 1000 PAH of cigarette smoke condensate and have led to the development of methods for the routine quantitation of PAH in smalI quantities of cigarette smoke condensate.

Simultaneous determination of eight derivatives of propranolol in cornea perfusate in vitro by high performance liquid chromatography

2013 ◽  
Vol 30 (11) ◽  
pp. 1183-1187
Author(s):  
Haitao WU ◽  
Chuanbing CHEN ◽  
Ningsheng WANG ◽  
Suiqing MI ◽  
Nanying LIAO
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
High Performance ◽  
Derivatives Of

scholarly journals Gas-liquid chromatography of dialkyl, alkyl acyl, and diacyl derivatives of glycerol

1969 ◽  
Vol 10 (1) ◽  
pp. 128-131
Author(s):  
Randall Wood ◽  
W.J. Baumann ◽  
Fred Snyder ◽  
H.K. Mangold
Keyword(s):  
Liquid Chromatography ◽  
Gas Liquid Chromatography ◽  
Derivatives Of

scholarly journals Pressurized Solvent Extraction with Ethyl Acetate and Liquid Chromatography—Tandem Mass Spectrometry for the Analysis of Selected Conazole Fungicides in Matcha

Toxics ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 64 ◽  
Author(s):  
Renata Raina-Fulton ◽  
Aisha Mohamad
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Solvent Extraction ◽  
Matrix Effects ◽  
Tandem Mass ◽  
Esi Ms ◽  
Signal Suppression ◽  
Target Analytes ◽  
Matrix Components ◽  
Pressurized Solvent Extraction

The extraction of powdered nutraceuticals is challenging due to the low water content and high concentration of matrix components that can lead to significant matrix effects in liquid chromatography-positive ion electrospray ionization-tandem mass spectrometry (LC-ESI+-MS/MS). In this study we assess the feasibility of using pressurized solvent extraction with ethyl acetate to reduce the co-extraction of polar matrix components. Pigment attributed to chlorophyll was removed with in-cell clean-up utilizing Anasorb 747, Florisil®, and C18. Visible inspection of the extracts showed that pigment was removed from matcha, a powdered green tea sample. Pressurized solvent extraction with in-cell clean-up can be utilized to remove pigments from powdered samples such as nutraceuticals. Average matrix effect of the 32 target analytes that observed mass spectrometric signal suppression or soft MS signal enhancement was −41 ± 19% with the majority of analytes having a protonated molecular ion with m/z of 250 to 412. As generally moderate signal suppression was observed for conazole fungicides and structurally related compounds analyzed by LC-ESI+-MS/MS, it is recommended that matrix matched or standard addition calibration is used for quantitation. Catachins, other polyphenols, and caffeine are expected to contribute to the matrix effects observed in LC-ESI+-MS/MS. Diniconazole, fenbuconazole, and tebufenozide were the only target analytes with severe MS signal enhancement. Low levels (0.002–0.004 mg/kg) of prothioconazole-desthio and flusilazole were detected, along with trace levels of tebuthiuron in matcha.

Determination of phenolic derivatives of antipyrine in plasma with HPLC-Tandem MS using ESI and turbo ion spray as interfaces

1999 ◽  
Vol 11 (10) ◽  
pp. 701-707 ◽  
Author(s):  
Stefan A. J. Coolen ◽  
Mark Van Lieshout ◽  
Jetse C. Reijenga ◽  
Fred A. Huf
Keyword(s):  
Tandem Ms ◽  
Phenolic Derivatives ◽  
Derivatives Of
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