Background. Polygenic risk scores (PRS) capture genetic vulnerability to psychiatric conditions and promise to advance our understanding of mental health etiology in children. Emerging evidence suggests that PRSs may be associated with higher-order dimensions of childhood psychopathology. The current study delineated a pattern of associations of major PRSs with an overarching general factor of psychopathology (p-factor), and five specific factors: externalizing, internalizing, neurodevelopmental, somatoform, and detachment.Method. The sample consisted of 4,717 unrelated children (mean age=9.92, SD=.62; 47.1% female; all European ancestry). Psychopathology was conceptualized hierarchically as empirically-derived general factor and five specific factors. Partial correlations explored associations between psychopathology factors and major psychopathology-related PRSs originally discovered in large samples (Ns>100,000). Regressions tested which level of the psychopathology hierarchy was most strongly associated with each PRS.Results. Four PRSs were associated primarily with the general factor (>60% of genetic effects were general): Depression-PRS, Neuroticism-PRS, PTSD-PRS, and Insomnia-PRS. Two PRS contributed comparably to general and specific psychopathology: Smoking-PRS and Number of Sexual Partners-PRS. Five PRSs contributed primary to specific factors (<40% of genetic effects were general): Adventurousness-PRS, Disinhibition-PRS, Educational Attainment-PRSs, BMI-PRS, and Intelligence-PRS. The incremental associations with specific factors were mainly driven by the externalizing dimension. Conclusion. The PRSs for internalizing problems predominantly captured non-specific genetic vulnerability to psychopathology in children. Conversely, PRSs for externalizing problems contributed to more specific psychopathology outcomes, most notably externalizing behavior. Overall, many major PRSs captured both general and specific genetic vulnerability to childhood psychopathology.