Use of Hormonal Contraceptives in Perimenopause: A Systematic Review

Abstract Background Previous studies indicated an impact of hormonal contraceptive use on oral health. This systematic review aimed to investigate the evidence supporting the impact of the use of hormonal contraceptives and periodontal diseases. Methods This study is based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and based on the PECO acrostic. Inclusion criteria comprised observational studies including women (P), which evaluated hormonal contraceptive users (E) and hormonal contraceptive non-users (C), to verify the association between this hormonal therapy and the periodontal diseases (O). Searches were performed on 5 databases: PubMed, Scopus, Web of Science, Cochrane Library, LILACS and grey literature (OpenGrey and Google Scholar). After the selection process, the included studies were evaluated qualitatively. Moreover, quantitative data were analyzed in two meta-analyses for clinical attachment loss (CAL) and probing depth (PD). Finally, the level of certainty was measured with the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) tool between periodontal clinical parameters. Results 18 articles were eligible for the qualitative synthesis and 7 of them were selected for quantitative analysis. Hence, 15 of the eligible articles reported an association between the use of hormonal contraceptives and severity of periodontal disease. However, 6 articles demonstrated high risk of bias and were excluded from quantitative synthesis. The meta-analysis showed a statistically significant difference for CAL (MD 0.24 [0.09, 0.40]; p = 0.002), but in PD (MD 0.05 [− 0.05, 0.15]; p = 0.33) such difference was not identified. A very low level of evidence was found between the clinical parameters. Conclusions The use of hormonal contraceptives may be associated to severity of periodontal diseases. However, the quantitative analysis points to an inconclusive outcome due to the high level of heterogeneity. The association is biologically plausible, however additional studies are warranted to better elucidate the clinical significance of this possible association.

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ALTERAÇÕES AUDITIVAS E VESTIBULARES DECORRENTES DO USO DE CONTRACEPTIVO HORMONAL ORAL: UMA REVISÃO SISTEMÁTICA / AUDITORY AND VESTIBULAR DISORDERS RESULTING FROM THE USE OF ORAL HORMONAL CONTRACEPTIVES: A SYSTEMATIC REVIEW

Brazilian Journal of Development ◽

10.34117/bjdv6n9-557 ◽

2020 ◽

Vol 6 (9) ◽

pp. 71523-71539

Author(s):

Alexsandra Ribeiro Ferreira ◽

Patricia Haas

Keyword(s):

Systematic Review ◽

Hormonal Contraceptives ◽

Vestibular Disorders

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Relationship between hormonal contraceptives and sleep among women of reproductive age: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2020-045819 ◽

2021 ◽

Vol 11 (10) ◽

pp. e045819

Author(s):

Jinhui Ma ◽

Megan Cheng ◽

Lehana Thabane ◽

Caihong Ma ◽

Ning Zhang ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Research Question ◽

Risk Of Bias ◽

Reproductive Age ◽

Hormonal Contraceptives ◽

Controlled Trials ◽

Cochrane Central Register ◽

Women Of Reproductive Age

IntroductionThe aetiology of sleep disruptions is unknown, but hormonal fluctuations during the menstrual cycle, pregnancy and menopause have been shown to potentially affect how well a woman sleeps. The aim of this systematic review was to investigate whether hormonal contraceptives are associated with a decreased quality of sleep and increased sleep duration in women of reproductive age.MethodsThis review will analyse data from randomised controlled trials or non-randomised comparative studies investigating the association between hormonal contraceptives and sleep outcomes among women of reproductive age. Reviews addressing the same research question with similar eligibility criteria will be included. A literature search will be performed using the MEDLINE, Embase and Cochrane Central Register of Controlled Trials databases from inception to 7 March 2021. The Cochrane Collaboration’s Risk of Bias for Randomised Trials V.2.0 and The Risk of Bias for Non-randomised Studies of Interventions tool will be used to assess risk of bias for each outcome in eligible studies. Two reviewers will independently assess eligibility of studies and risk of bias and extract the data. All extracted data will be presented in tables and narrative form. For sleep measures investigated by two or more studies with low heterogeneity, we will conduct random-effects meta-analysis to estimate the magnitude of the overall effect of hormonal contraceptives. If studies included in this systematic review form a connected network, a network meta-analysis will be conducted to estimate the comparative effect of different contraceptives. The Grading of Recommendations, Assessment, Development, and Evaluation approach will be used to summarise the quality of evidence. Our protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols 2015 guidelines.Ethics and disseminationEthics approval is not required as data were sourced from previously reported studies. The findings of this review will be published in a peer-reviewed journal and presented at relevant conferences.PROSPERO registration numberCRD42020199958.

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0830 Hormonal Contraceptive Use and Sleep: A Systematic Review and Meta-Analysis

SLEEP ◽

10.1093/sleep/zsaa056.826 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A316-A316

Author(s):

A G Bezerra ◽

G Pires ◽

M L Andersen ◽

S Tufik ◽

H Hachul

Keyword(s):

Systematic Review ◽

Effect Size ◽

Full Text ◽

Contraceptive Use ◽

Total Sleep Time ◽

Meta Analysis ◽

Hormonal Contraception ◽

Sleep Time ◽

Hormonal Contraceptives ◽

Bibliographic Search

Abstract Introduction The effects of hormonal contraceptives on sleep has been matter of debate in current literature. While some articles observed a sleep promoting effect and reduced sleep disordered breathing, others have failed to detect any result or even detected a worse sleep pattern in women using hormonal contraception. As the literature has been growing on this field, a systematic review is necessary to gather and compare all the studies in a comprehensive way. Methods A bibliographic search was conducted in Pubmed, Scopus and Web of Science. Studies were selected first based on titles and abstracts, followed by full text analysis and data extraction. Only original studies evaluating women using hormonal contraception were considered eligible. Both objective and subjective sleep-related outcomes were extracted for analyzes. Individual effect size for each articles was calculated using regular or standardized mean differences and meta-analyses were conducted using a DerSimonian and Laird random effects model. Results After the bibliographic search, 1787 non-duplicated articles were included in our initial data screening. Articles sample was reduced to 114 records after abstract screening and to ten studies after full text analyses. The following sleep outcomes were eligible for meta-analysis: Pittsburgh Sleep Quality Index (PSQI - 3 studies), total time in bed (4), subjective total sleep time (4), objective total sleep time (3), sleep latency (6), sleep efficiency (6). None of them resulted in statistically significant effects of contraceptive use and the effect size ± 95% interval of confidence overlapped the zero value. Conclusion Hormonal contraceptives is not associated to any alteration in sleep patterns in women. This conclusion should be restricted to a general framework, since our sample does not allowed stratified analyses. Future studies should consider the effect of specific hormonal composition (ex.: combined vs. progestogen-only contraceptives) and administration route (contraceptive pills vs. levonorgestrel intrauterine device). Support AFIP, CAPES, CNPq

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PIH19 A SYSTEMATIC REVIEW OF PHARMACOECONOMIC LITERATURE SCORING TOOLS FOR STUDIES ON HORMONAL CONTRACEPTIVES

Value in Health ◽

10.1016/j.jval.2019.04.819 ◽

2019 ◽

Vol 22 ◽

pp. S185-S186

Author(s):

A. White ◽

G. Adunlin ◽

M. Srinivasan ◽

S.K. Peasah

Keyword(s):

Systematic Review ◽

Hormonal Contraceptives ◽

Scoring Tools

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Does use of hormonal contraceptives among women with thrombogenic mutations increase their risk of venous thromboembolism? A systematic review

Contraception ◽

10.1016/j.contraception.2005.08.011 ◽

2006 ◽

Vol 73 (2) ◽

pp. 166-178 ◽

Cited By ~ 45

Author(s):

Anshu P. Mohllajee ◽

Kathryn M. Curtis ◽

Summer L. Martins ◽

Herbert B. Peterson

Keyword(s):

Systematic Review ◽

Venous Thromboembolism ◽

Hormonal Contraceptives

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Does use of hormonal contraceptives among women with thrombogenic mutations increase their risk of venous thromboembolism? A systematic review

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70154-1 ◽

2007 ◽

Vol 2007 ◽

pp. 217-218

Author(s):

N.B. Zite

Keyword(s):

Systematic Review ◽

Venous Thromboembolism ◽

Hormonal Contraceptives

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Effect of menstrual cycle phase, menstrual irregularities and hormonal contraceptive use on anterior knee laxity and non-contact anterior cruciate ligament injury occurrence in women: a protocol for a systematic review and meta-analysis

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2021-001170 ◽

2021 ◽

Vol 7 (4) ◽

pp. e001170

Author(s):

Elisa Nédélec ◽

Elvis Foli ◽

Sandra J Shultz ◽

Paul A Swinton ◽

Eimear Dolan ◽

...

Keyword(s):

Systematic Review ◽

Menstrual Cycle ◽

Cruciate Ligament ◽

Meta Analysis ◽

Ligament Injury ◽

Secondary Outcome ◽

Hormonal Contraceptives ◽

Cycle Phase ◽

Acl Injuries ◽

Anterior Knee

Exercising women report three to six times more ACL tears than men, which happen, in the majority of cases, with a non-contact mechanism. This sex disparity has, in part, been attributed to the differences in reproductive hormone profiles between men and women. Many studies have shown that anterior knee (AK) laxity and the rate of non-contact ACL injuries vary across the menstrual cycle, but these data are inconsistent. Similarly, several studies have investigated the potential protective effect of hormonal contraceptives on non-contact ACL injuries, but their conclusions are also variable. The purpose of this systematic review and meta-analysis is to, identify, evaluate and summarise the effects of endogenous and exogenous ovarian hormones on AK laxity (primary outcome) and the occurrence of non-contact ACL injuries (secondary outcome) in women. We will perform a systematic search for all observational studies conducted on this topic. Studies will be retrieved by searching electronic databases, clinical trial registers, author’s personal files and cross-referencing selected studies. Risk of bias will be assessed using the Newcastle Ottawa Quality Assessment Scale for Cohort and Case–Control Studies. Certainty in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. The meta-analyses will use a Bayesian approach to address specific research questions in a more intuitive and probabilistic manner. This review is registered on the international database of prospectively registered systematic reviews (PROSPERO; CRD42021252365).

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