Use of computerized tomography and chest X‐rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study

ObjectivesCumulative radiation exposure is associated with increased risk of malignancy. This is important in cystic fibrosis (CF) as frequent imaging is required to monitor disease progression and diagnose complications. Previous estimates of cumulative radiation are outdated as the imaging was performed on older equipment likely to deliver higher radiation. Our objectives were to determine the radiation dose delivered to children during common radiological investigations using modern equipment and to identify the number of such investigations performed in a cohort of children with CF to calculate their cumulative radiation exposure.Design, setting and participantsData including age at investigation and radiation exposure measured as estimated effective dose (EED) were collected on 2827 radiological studies performed on children at one UK paediatric centre. These were combined with the details of all radiological investigations performed on 65 children with CF attending the same centre to enable calculation of each child’s cumulative radiation exposure.ResultsThe mean EED for the common radiological investigations varied according to age. The range was 0.01–0.02 mSv for chest X-rays, 0.03–0.11 mSv for abdominal X-rays, 0.57–1.69 mSv for CT chest, 2.9–3.9 mSv for abdominal and pelvic CT, 0.20–0.21 mSv for sinus CT and 0.15–0.52 mSv for fluoroscopy-guided procedures. The mean EED was three to five times higher for helical compared with axial chest CT scans. The mean annual cumulative EED for our cohort of children with CF was 0.15 mSv/year with an estimated cumulative paediatric lifetime EED (0–18 years) of 3.5 mSv.ConclusionsThis study provides up-to-date estimations of the radiation exposure when using common radiological investigations. These doses and the estimates of cumulative radiation exposure in children with CF are lower than previously reported. This reflects the reduced EED associated with modern equipment and the use of age-specific scanning protocols.

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Visualization of Laboratory Corefloods With the Aid of Computerized Tomography of X-Rays

SPE Reservoir Engineering ◽

10.2118/13654-pa ◽

1987 ◽

Vol 2 (02) ◽

pp. 148-154 ◽

Cited By ~ 18

Author(s):

A.O. Hove ◽

J.K. Ringen ◽

P.A. Read

Keyword(s):

Computerized Tomography ◽

X Rays

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Preliminary Study on the Anti-radiation Effect of Jen-Sheng-Yang-Yung-Tang

The American Journal of Chinese Medicine ◽

10.1142/s0192415x93000224 ◽

1993 ◽

Vol 21 (02) ◽

pp. 187-195 ◽

Cited By ~ 7

Author(s):

Hsue-yin Hsu ◽

Yau-hui Ho ◽

Shi-Iong Lian ◽

Chun-ching Lin

Keyword(s):

Bone Marrow ◽

Radiation Effect ◽

Bone Marrow Cells ◽

X Rays ◽

Male Mice ◽

X Ray ◽

Colony Forming Units ◽

Before And After ◽

Preliminary Study ◽

Different Doses

Six to seven week old male mice of ICR strain were exposed to different doses of x-rays to determine if Jen-Sheng-Yang-Yung-Tang could be a modifier in the elimination of radiation damage. Colony forming units of bone marrow cells in the spleen (CFUs) were measured before and after x-ray irradiation with intraperitoneal injection of 10 mg/20 g or 20 mg/20 g body weight of Jen-Sheng-Yang-Yung-Tang, once a day for seven consecutive days. The recovery of CFUs and hemocytes counts by 4 Gy irradiation with Jen-Sheng-Yang-Yung-Tang administration was faster for a concentration of 20 mg/20 g than 10 mg/20 g. The measurement of 10-day CFUs showed an increase of radiotolerance in the treatment of 20 mg/20 g administration before x-ray irradiation. The injection of Jen-Sheng-Yang-Yung-Tang accelerated the recovery of hemocyte counts in mice irradiated with 4 Gy x-ray; the effect was especially profound for leukocytes with 20 mg/20 g Jen-Sheng-Yang-Yung-Tang administration after irradiation.

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Two-year observation of the occlusal vertical dimension after bite raising via cone-beam computerized tomography: A preliminary study

Scientific Reports ◽

10.1038/s41598-019-39662-9 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Chuanzi Liu ◽

Dan Huang ◽

Lizhi Zhou ◽

Guochen Liu ◽

Yining Wang ◽

...

Keyword(s):

Computerized Tomography ◽

Vertical Dimension ◽

Cone Beam ◽

Occlusal Vertical Dimension ◽

Cone Beam Computerized Tomography ◽

Preliminary Study

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WS10.5 Dietary patterns and body composition in paediatric cystic fibrosis patients: preliminary study

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(20)30220-4 ◽

2020 ◽

Vol 19 ◽

pp. S17

Author(s):

M. Mielus ◽

P. Madej ◽

M. Surowiecka ◽

K. Zybert ◽

U. Borawska-Kowalczyk ◽

...

Keyword(s):

Cystic Fibrosis ◽

Body Composition ◽

Dietary Patterns ◽

Preliminary Study

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Paranasal Sinus Mucoceles in Cystic Fibrosis

American Journal of Rhinology ◽

10.2500/105065893781976609 ◽

1993 ◽

Vol 7 (1) ◽

pp. 31-35 ◽

Cited By ~ 12

Author(s):

William E. Davis ◽

Giulio J. Barbero ◽

William R. LaMear ◽

Jerry W. Templer ◽

Peter Konig

Keyword(s):

Cystic Fibrosis ◽

Paranasal Sinus ◽

Computerized Tomography ◽

Paranasal Sinuses ◽

Endoscopic Sinus Surgery ◽

Functional Endoscopic Sinus Surgery ◽

The Other ◽

Sinus Surgery ◽

Lateral Nasal Wall ◽

Osteomeatal Complex

Six patients between the ages of 6 and 22 years old with cystic fibrosis were found to have mucoceles of the paranasal sinuses. Four were male and two were female. They experienced nasal obstruction, purulent rhinorrhea, and anosmia, but none had fever or pain. Nasal endoscopy and coronal computerized tomography scans revealed the lateral nasal wall to be displaced medially against the septum. Functional endoscopic sinus surgery revealed large cystic spaces filled with thick yellow-green mucus. Postoperatively most patients are able to smell and breathe through their noses. The mucocele probably begins as an obstructed anterior ethmoid cell, which then enlarges and obstructs the osteomeatal complex, which further impairs drainage of the other sinuses into this area.

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Diagnostic value of chest ultrasound in children with cystic fibrosis

10.1101/604942 ◽

2019 ◽

Author(s):

Lidia Strzelczuk-Judka ◽

Irena Wojsyk-Banaszak ◽

Aleksandra Zakrzewska ◽

Katarzyna Jonczyk-Potoczna

Keyword(s):

Cystic Fibrosis ◽

Life Expectancy ◽

Disease Progression ◽

Genetic Disorders ◽

Life Quality ◽

Diagnostic Procedures ◽

Diagnostic Value ◽

Radiographic Examination ◽

X Rays ◽

X Ray

AbstractCystic fibrosis (CF) is one of the most common genetic disorders in the Caucasian population. The disease has a progressive course and leads to reduced life quality and life expectancy. Standard diagnostic procedures used in the monitoring of CF patients, include methods exposing patients to the ionizing radiation. With increasing life expectancy in CF the cumulative dose of ionising radiation increases, prompting clinicians’ search for safer imaging studies. Despite its safety and availability lung ultrasound (LUS) is not routinely used in the diagnostic evaluation of CF patients.The aim of the study was to evaluate the diagnostic value of LUS in children with CF compared to chest X-ray, and to assess the diagnostic value of the recently developed LUS score - CF-USS (Cystic Fibrosis Ultrasound Score).LUS was performed in 48 CF children aged from 5 to 18 years (24 girls and 24 boys). LUS consisted in the assessment of the pleura, lung sliding, A-line and B-line artifacts, “lung rockets”, alveolar consolidations, air bronchogram and pleural effusion. Chest radiography was performed in all patients and analyzed according to the modified Chrispin-Norman score. LUS was analyzed according to CF-USS.Correlation between the CF-USS and the modified Chrispin-Norman scores were moderate (R=0.52, p=0.0002) and strong in control studies. In 75% of patients undergoing LUS, small areas of subpleural consolidations were observed, not visible on X-rays. At the same time, LUS was not sensitive enough to visualize bronchial pathology, which plays an important role in assessing the disease progression.ConclusionsLUS constitutes an invaluable tool for the diagnosis of subpleural consolidations. CF-USS results correlate with conventional x-ray modified Chrispin–Norman score. LUS should be considered an accessory radiographic examination in the monitoring of CF patients, and CF-USS may provide clinicians with valuable information concerning the disease progression.

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