Protective effects of Danshen (Salvia Miltiorrhiza) on adriamycin-induced cardiac and hepatic toxicity in rats

2007 ◽  
Vol 21 (12) ◽  
pp. 1146-1152 ◽  
Author(s):  
Jyh-Sheng You ◽  
Tai-Long Pan ◽  
Ying-Shiung Lee
Keyword(s):  
Salvia Miltiorrhiza ◽  
Protective Effects ◽  
Hepatic Toxicity

scholarly journals Combined Lipidomics and Network Pharmacology Study of Protective Effects of Salvia miltiorrhiza against Blood Stasis Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yidian Jin ◽  
Zhiru Xie ◽  
Shasha Li ◽  
Xiangyu Zeng ◽  
Leqi Wang ◽  
...  
Keyword(s):  
Salvia Miltiorrhiza ◽  
Blood Stasis ◽  
Ether Lipid ◽  
Blood Stasis Syndrome ◽  
Network Pharmacology ◽  
Fibrinogen Concentration ◽  
Protective Effects ◽  
Critical Pathways ◽  
Protection Mechanism ◽  
Beneficial Effects

Blood stasis syndrome (BSS) is one of the most common symptoms of cardiovascular diseases (CVDs) in traditional Chinese medicine (TCM) theory. Previous studies have identified that Salvia miltiorrhiza (Danshen) has beneficial effects on BSS, but there is no relevant research from the perspective of lipidomics to study the mechanism of Danshen against BSS since hyperlipidemia has been the widely accepted risk factor of CVDs. In this study, lipidomics technology combined with network pharmacology was applied to investigate the pathological mechanism of BSS and the protective effects of Danshen. The lipidomics profiling based on the UPLC-QTOF-MS analysis method was applied to identify the differential metabolites in the plasma of blood stasis rats. The related pathway and potential targets involved in the anti-BSS effects of Danshen were predicted by pathway analysis and network pharmacology. The biochemical results showed that Danshen intervention significantly reduced whole blood viscosity (WBV) at all the shear rates and fibrinogen concentration (FIB) p < 0.01 and increased activated partial thromboplastin time (APTT) effectively p < 0.01 . We also found that 52 lipid metabolites, including glycerophospholipid, sphingolipid, glycerolipid, plasmalogen, cholesterol ester, and testosterone, were associated with blood stasis. Moreover, Dgka, Hsd17b3, Hsd3b1, Inppl1, Lpl, Pik3ca, Pik3r1, Pla2g1b, Pla2g2a, Soat1, and Soat2 were predicted as potential targets, while glycerophospholipid metabolism, glycerolipid metabolism, steroid and steroid hormone biosynthesis, phosphatidylinositol signaling system, and ether lipid metabolism were involved as shared critical pathways of lipidomics analysis and network pharmacology. Collectively, this study offered a new understanding of the protection mechanism of Danshen against BSS, which provided new insight to explore the protective effects of Danshen.

scholarly journals Tanshinone I Inhibits Oxidative Stress–Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu-Ting Wu ◽  
Ling-Peng Xie ◽  
Yue Hua ◽  
Hong-Lin Xu ◽  
Guang-Hong Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Knockout Mice ◽  
Salvia Miltiorrhiza ◽  
Mapk Signaling ◽  
Related Factor ◽  
Protective Effects ◽  
H9c2 Cells ◽  
Tanshinone I ◽  
Nrf2 Knockout ◽  
And Oxidative Stress

Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most common causes of death worldwide, and oxidative stress plays a major role in its pathophysiology. Tanshinone I (Tan I), a natural compound with cardiovascular protective effects, is one of the main active compounds extracted from Salvia miltiorrhiza. Here, we investigated whether Tan I could attenuate oxidative stress and oxidative stress–induced cardiomyocyte apoptosis through Nrf2/MAPK signaling in vivo and in vitro. We found that Tan I treatment protected cardiomyocytes against oxidative stress and oxidative stress–induced apoptosis, based on the detection of relevant oxidation indexes such as reactive oxygen species, superoxide dismutase, malondialdehyde, and apoptosis, including cell viability and apoptosis-related protein expression. We further examined the mechanisms underlying these effects, determining that Tan I activated nuclear factor erythroid 2 (NFE2)–related factor 2 (Nrf2) transcription into the nucleus and dose-dependently promoted the expression of Nrf2, while inhibiting MAPK signaling activation, including P38 MAPK, SAPK/JNK, and ERK1/2. Nrf2 inhibitors in H9C2 cells and Nrf2 knockout mice demonstrated aggravated oxidative stress and oxidative stress–induced cardiomyocyte injury; Tan I treatment suppressed these effects in H9C2 cells; however, its protective effect was inhibited in Nrf2 knockout mice. Additionally, the analysis of surface plasmon resonance demonstrated that Tan I could directly target Nrf2 and act as a potential Nrf2 agonist. Collectively, these data strongly indicated that Tan I might inhibit oxidative stress and oxidative stress–induced cardiomyocyte injury through modulation of Nrf2 signaling, thus supporting the potential therapeutic application of Tan I for oxidative stress–induced CVDs.

scholarly journals Quantitative proteomics reveals the protective effects of ESD against osteoarthritis via attenuating inflammation and modulating immune response

2020 ◽  
Author(s):  
Ying Hao ◽  
Yang Wu ◽  
Shanglong Wang ◽  
Chungguo Wang ◽  
Sihao Qu ◽  
...  
Keyword(s):  
Quantitative Proteomics ◽  
Salvia Miltiorrhiza ◽  
Cartilage Degradation ◽  
Protein Profiling ◽  
Behavioral Activity ◽  
Potential Candidate ◽  
Protective Effects ◽  
Label Free ◽  
Long Time ◽  
Proteolysis Regulation

AbstractEpimedium, Salvia miltiorrhiza, and Dioscorea nipponica Makino (ESD) have been combined to treat osteoarthritis (OA) for a long time. In this study we used quantitative proteomics to find the protective effects of ESD against OA and possible mechanism. After papain-induced rats’ OA model established ESD was intragastrically administrated to rats for four weeks. Label-free quantitative proteomics was used to screen the comprehensive protein profiling changes in both OA and ESD groups. After stringent filtering, 62 proteins were found to be significantly up-regulated and 208 proteins were down-regulated in OA model compared with sham-operated control. Functional analysis revealed that these OA up-regulated proteins were enriched in the activation of humoral immunity response, complement activation, leukocyte mediated immunity, acute inflammatory, endocytosis regulation, and proteolysis regulation. ESD partially recovered the protein profiling changes in OA model. The effects of ESD were also assessed by measurement of behavioral activity and pathologic changes in the joints. ESD showed protective effects in suppressing inflammation, releasing joint pain, and attenuating cartilage degradation. Our study presented that ESD as a potential candidate to alleviate OA damage by reducing inflammation and modulating of immune system.

The protective effects of ascorbic acid, cimetidine, and nifidipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats

2011 ◽  
Vol 34 (4) ◽  
pp. 405-419 ◽  
Author(s):  
Khadiga Mohammed Gaafa ◽  
Mohammed M. Badawy ◽  
Alaaeldin A. Hamza
Keyword(s):  
Ascorbic Acid ◽  
Albino Rats ◽  
Protective Effects ◽  
Hepatic Toxicity

Involvement of the different extracts from roots of Salvia miltiorrhiza Bunge on acute hypobaric hypoxia-induced cardiovascular effects in rats – preliminary report

2012 ◽  
Vol 15 (4) ◽  
pp. 693-701 ◽  
Author(s):  
W. Buchwald ◽  
P.Ł. Mikołajczak ◽  
A. Krajewska-Patan ◽  
M. Dreger ◽  
M. Górska-Paukszta ◽  
...  
Keyword(s):  
Hypobaric Hypoxia ◽  
Salvia Miltiorrhiza ◽  
Cardiovascular Effects ◽  
Protective Effects ◽  
Heart Activity ◽  
Salvia Miltiorrhiza Bunge ◽  
Acute Hypobaric Hypoxia ◽  
Arterial Blood ◽  
Male Wistar Rats ◽  
Systolic Arterial Blood Pressure

Abstract The present study was carried out to investigate the protective effects of roots of Salvia miltiorrhiza Bunge on hypobaric hypoxia. Two extracts of S. miltiorrhiza (extract 1: ethanol : water - 50 : 50; extract 2: 96% ethanol) were used. The experiments were performed after 7 consecutive days of administration of the extracts (200 mg/kg b.w., intragastrically) to male Wistar rats. Next, after placing animals for 60 min in the controlled acute hypobaric hypoxia (500 mm Hg) the systolic arterial blood pressure (SAP) in conscious rats, bioelectric heart activity in unconscious rats and analysis of oxidative stress parameters in the blood of rats: malonyldialdehyde (MDA) and lipid peroxidase (LPO) concentration, activity of superoxide dismutase (SOD) or glutathione peroxidase (GPX) were assayed. It was found out that the extract 1 augmented the lowering of SAP shown in hypoxia affected control rats. On the contrary the extract 2 reversed SAP to values obtained in control animals. Moreover, both extracts led to the normalization of hypoxia-induced tachycardia and levels of MDA, LPO and SOD. It seems that the above-mentioned effects are coupled with different active compounds content in the extracts, however more studies are needed to confirm this hypothesis.

Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction

Life Sciences ◽  
2004 ◽  
Vol 75 (26) ◽  
pp. 3157-3171 ◽  
Author(s):  
K. Chan ◽  
S.H. Chui ◽  
D.Y.L. Wong ◽  
W.Y. Ha ◽  
C.L. Chan ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Aqueous Extract ◽  
Salvia Miltiorrhiza ◽  
Protective Effects

scholarly journals The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yalan Wu ◽  
Suowen Xu ◽  
Xiao Yu Tian
Keyword(s):  
Cardiovascular Diseases ◽  
Salvia Miltiorrhiza ◽  
Water Soluble ◽  
Salvianolic Acid B ◽  
Drug Candidate ◽  
Protective Effects ◽  
Vascular Protection ◽  
Salvianolic Acid ◽  
Salvianolic Acid A

Salvia miltiorrhiza (Danshen), as an important traditional Chinese medicinal plant, has been used in China for the treatment of cardiovascular diseases for hundreds of years. Salvianolic acids (salvianolic acid A and salvianolic acid B) as the most abundant water-soluble component extracted from Salvia miltiorrhiza have attracted more and more attention from cardiovascular scientists due to its comprehensive cardiovascular actions. In vivo and in vitro studies have rendered salvianolic acid an excellent drug candidate for the treatment and prevention of cardiovascular diseases. In this review, we surveyed the protective effects of salvianolic acid A and salvianolic acid B against cardiovascular diseases and the pharmacological basis, providing a strong scientific rationale for elucidating the important role of Salvia miltiorrhiza in cardiovascular therapy. More importantly, we also hope to provide new inspiration and perspectives on the development and innovation of small-molecule cardiovascular drugs based on salvianolic acid.

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