Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): further biological activities and constituents

2001 ◽  
Vol 15 (8) ◽  
pp. 687-690 ◽  
Author(s):  
Solomon Habtemariam
Keyword(s):  
Antiinflammatory Activity ◽  
Biological Activities ◽  
Herbal Drug

scholarly journals Assessment of Secondary Metabolites with Different Uses of Fenugreek

2021 ◽  
Author(s):  
Gulsum Yaldiz ◽  
Mahmut Camlica
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
New Drugs ◽  
Herbal Drug ◽  
Primary Metabolite ◽  
Food Industries ◽  
Golden Yellow ◽  
Therapeutic Properties ◽  
Modern Breeding ◽  
Nutraceutical Properties

Fenugreek (Trigonella foenum-graecum) is an annual medicinal plant with trifoliate leaves, a branched stem, white flowers, rooted tubers, and golden yellow seed belonging to Fabaceae family. Fenugreek is used in different industries such as pharmaceutical, nutraceutical and food industries as an ancient crop plant. Fenugreek is grown as a medicinal herb in many countries and has antioxidant, hypoglycemic, hypercholesterolemia, stomach protective, chemopreventive, laxative and appetite stimulating properties. In recent years, many important studies have been conducted on the biological activities and therapeutic properties of fenugreek mainly secondary metabolites such as alkaloids, flavonoids, steroids and saponins. These compounds are used for multipurpose uses in different industries and also appreciated by scientists. Based on these several health usefulness as discussed in review, fenugreek might be a good candidate for a herbal drug and used for preparation of new drugs. In this review, secondary metabolites used in different industries of fenugreek will be discussed and general benefits of them will be expressed within the all significant aspect of fenugreek as clearly. This review also highlights the traditional uses and nutraceutical properties (antioxidant activity, antibacterial, antifungal, anticancer hypoglemic effects and anti-inflammatory and immunological activity) of fenugreek. These uses and effect properties of fenugreek have been discussed and researchable areas were implied to depending on the previous studies. In the future, studies on fenugreek are needed some important applications to increasing the popularity of fenugreek. In this context, researchers should be focused on secondary and primary metabolite studies in fenugreek seeds and leaves. In addition to these, fenugreek germplasm should be collected and subjected to intensive selection via modern breeding programs and new fenugreek genotypes with desired properties should be obtained.

Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds

2020 ◽  
Vol 20 (28) ◽  
pp. 2578-2598
Author(s):  
Chen Xu ◽  
Meng-Yuan Fang ◽  
Ke Wang ◽  
Jing Liu ◽  
Guang-Ping Tai ◽  
...  
Keyword(s):  
Antiinflammatory Activity ◽  
Biological Activities ◽  
Inflammatory Activity ◽  
Oxidation Degree ◽  
Anti Inflammatory ◽  
Anti Tumor Activity

: Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

scholarly journals MUSCARI ARMENIACUM LEICHTLIN (GRAPE HYACINTH): PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES REVIEW

2019 ◽  
Vol 12 (1) ◽  
pp. 68
Author(s):  
Dmitry Olegovich Bokov
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Antimutagenic Activity ◽  
Therapeutic Effects ◽  
Herbal Drug ◽  
Ribosome Inactivating Proteins ◽  
Phytochemical Studies ◽  
Active Substances

This review focuses on the Muscari armeniacum Leichtlin (Asparagaceae Juss) biologically active substances composition presented in the Aireal and underground parts and finding their possible therapeutic effects. The systematic review is dedicated to the composition of biologically active substances, including recent advances in the biological activity investigation, phytochemical studies, and biotechnology methods of plant material producing. Various electronic search engines such as Google, Google Scholar, scientific literature, publishing sites, and electronic databases such as PubMed, Wiley, Springer, and Science Direct had been searched and data obtained. Other online academic libraries such as E-library and specific ethnopharmacological literature had been searched systematically for more exhaustive information on the crude herbal drug. The chemical composition of M. armeniacum biologically active substances is established; it contains anthocyanins (delphinidin and cyanidin derivatives), homoisoflavonoids, polyhydroxylated pyrrolizidine alkaloids (hyacinthacines A1, A2, A3, and B3), oligoglycosides (Muscarosides), and ribosome-inactivating proteins (musarmins). Recent physicochemical analytical procedures for components determination and hyacinthacines synthesis pathways are mentioned. Moreover, future prospects and trends in the research of this plant have been proposed. We have reviewed researches conducted on M. armeniacum especially in areas of its use in medicine, phytochemicals, biological activity, and developed analytical methods. M. armeniacum possesses antioxidant, antimutagenic activity, and specific glycosidase inhibitory activity; M. armeniacum can be used for the production of potential anticancer, antiviral, antidiabetic, and anti-obesity drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for giving further information on the clinical practice and standardization procedures for the crude herbal drug.

Use of QSAR in design of antiinflammatory fluorinated arylalkanoic acids

1990 ◽  
Vol 55 (1) ◽  
pp. 296-306 ◽  
Author(s):  
Miroslav Kuchař ◽  
Jaroslava Grimová ◽  
Václav Rejholec ◽  
Hana Tomková ◽  
Magda Jelínková ◽  
...  
Keyword(s):  
Antiinflammatory Activity ◽  
Hydrophobic Interactions ◽  
Biological Activities ◽  
Regression Equations ◽  
Chemical Parameters ◽  
Pharmacological Profile ◽  
Physico Chemical ◽  
Layer Chromatography ◽  
Fibrinolytic Capacity ◽  
Good Coincidence

A series of 3-fluro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated. The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected. Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations. Good coincidence was found out, as well as similarity of the regression derived for the original series of acids extended by the acids III. Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.

scholarly journals ISOXAZOLE – A POTENT PHARMACOPHORE

2017 ◽  
Vol 9 (7) ◽  
pp. 13 ◽  
Author(s):  
Krishna Veni Chikkula ◽  
Raja S.
Keyword(s):  
Antiinflammatory Activity ◽  
Biological Activities ◽  
Glutamate Transporter ◽  
Ibotenic Acid ◽  
Antitubercular Activity ◽  
Nitric Oxide Donor ◽  
Antihypertensive Activity ◽  
Cns Activity ◽  
Agonistic Activity ◽  
Cox 2

Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib. Furoxan, a nitric oxide donor is containing isoxazolyl group & found in many β-lactamase resistant antibiotics, such as cloxacillin, dicloxacillin and flucloxacillin. The synthetic androgenic steroid danazol also has an isoxazole ring. The substituted isoxazoles are well developed in literature to posses significant biological activities. The disubstituted and trisubstituted isoxazoles have been reported to exhibit broad range of biological activities such as antimicrobial activity, analgesic activity, antiinflammatory activity, antioxidant activity, anticancer activity, CNS activity, antitubercular activity and miscellaneous activities like GABA agonistic activity, inhibitory activity, antihypertensive activity, and glutamate transporter activity. The present review summarizes up to date information of various biological activities of isoxazole analogs.

scholarly journals Cordia macleodii Hook f. Thomson-A potential Medicinal Plant

2017 ◽  
Vol 9 (3) ◽  
pp. 394
Author(s):  
Jagriti Chandrakar ◽  
A K Dixit
Keyword(s):  
Medicinal Plant ◽  
Bioactive Compounds ◽  
Pharmacological Property ◽  
Biological Activities ◽  
Deciduous Forests ◽  
Herbal Drug ◽  
Volatile Oils ◽  
Traditional Uses ◽  
Endangered Medicinal Plant ◽  
Phytochemical Constituents

<p><em>Cordia macleodii</em> Hook. f. &amp; Thoms. belongs to family Boraginaceae, is an  endangered medicinal plant, commonly known as “Dahiman” or “Dahipalas”. It is distributed in moist and dry deciduous forests of India such as Chhattisgarh, Madhya Pradesh, Odisha, Chotanagpur and is widely used to cure various diseases. These bioactive compounds made this plant as a valuable potent herbal drug. It contains various bioactive compounds including Phenols, Terpenoids, Saponins, Volatile oils, Flavonoids, Glycosides etc. This review presents the pharmacological property, phytochemical constituents, traditional uses and biological activities of the plant and it will be helpful to explore the knowledge about <em>Cordia macleodii</em>.</p>

scholarly journals MUSCARI ARMENIACUM LEICHTLIN (GRAPE HYACINTH): PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES REVIEW

2019 ◽  
Vol 12 (1) ◽  
pp. 68
Author(s):  
Dmitry Olegovich Bokov
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Antimutagenic Activity ◽  
Therapeutic Effects ◽  
Herbal Drug ◽  
Ribosome Inactivating Proteins ◽  
Phytochemical Studies ◽  
Active Substances

This review focuses on the Muscari armeniacum Leichtlin (Asparagaceae Juss) biologically active substances composition presented in the Aireal and underground parts and finding their possible therapeutic effects. The systematic review is dedicated to the composition of biologically active substances, including recent advances in the biological activity investigation, phytochemical studies, and biotechnology methods of plant material producing. Various electronic search engines such as Google, Google Scholar, scientific literature, publishing sites, and electronic databases such as PubMed, Wiley, Springer, and Science Direct had been searched and data obtained. Other online academic libraries such as E-library and specific ethnopharmacological literature had been searched systematically for more exhaustive information on the crude herbal drug. The chemical composition of M. armeniacum biologically active substances is established; it contains anthocyanins (delphinidin and cyanidin derivatives), homoisoflavonoids, polyhydroxylated pyrrolizidine alkaloids (hyacinthacines A1, A2, A3, and B3), oligoglycosides (Muscarosides), and ribosome-inactivating proteins (musarmins). Recent physicochemical analytical procedures for components determination and hyacinthacines synthesis pathways are mentioned. Moreover, future prospects and trends in the research of this plant have been proposed. We have reviewed researches conducted on M. armeniacum especially in areas of its use in medicine, phytochemicals, biological activity, and developed analytical methods. M. armeniacum possesses antioxidant, antimutagenic activity, and specific glycosidase inhibitory activity; M. armeniacum can be used for the production of potential anticancer, antiviral, antidiabetic, and anti-obesity drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for giving further information on the clinical practice and standardization procedures for the crude herbal drug.

Improvement of cytoprotective and antioxidant activity of Rosa canina L. and Salix alba L. by controlled differential sieving process against H2O2-induced oxidative stress in mouse primary splenocytes

2017 ◽  
Vol 87 (3-4) ◽  
pp. 191-200 ◽  
Author(s):  
Nidhal Soualeh ◽  
Aliçia Stiévenard ◽  
Elie Baudelaire ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Good Alternative ◽  
Activity Levels ◽  
Salix Alba ◽  
Rosa Canina ◽  
Free Process ◽  
Plant Powders ◽  
Sieving Process

Abstract. In this study, cytoprotective and antioxidant activities of Rosa canina (RC) and Salix alba (SA), medicinal plants, were studied on mouse primary splenocytes by comparing Controlled Differential Sieving process (CDSp), which is a novel green solvent-free process, versus a conventional technique, employing hydroethanolic extraction (HEE). Thus, preventive antioxidant activity of three plant powders of homogeneous particle sizes, 50–100 µm, 100–180 µm and 180–315 µm, dissolved directly in the cellular buffer, were compared to those of hydroethanolic (HE) extract, at 2 concentrations (250 and 500 µg/mL) in H2O2-treated spleen cells. Overall, compared to HE extract, the superfine powders, i. e., fractions < 180 µm, at the lowest concentration, resulted in greater reactive oxygen species (ROS) elimination, increased glutathione peroxidase (GPx) activity and lower malondialdehyde (MDA) production. Better antioxidant and preventive effects in pre-treated cells were found with the superfine powders for SA (i. e., 50–100 µm and 100–180 µm, both p < 0.001), and with the intermediate powder for RC (i. e., 100–180 µm, p < 0.05) versus HE extract. The activity levels of catalase (CAT) and superoxide dismutase (SOD) in pretreated splenocytes exposed to H2O2, albeit reduced, were near to those in unexposed cells, suggesting that pretreatment with the fine powders has relatively restored the normal levels of antioxidant-related enzymes. These findings supported that CDSp improved the biological activities of plants, avoiding the use of organic solvents and thus it could be a good alternative to conventional extraction techniques.

Shape‐controlled silver NPs for shape‐dependent biological activities

2017 ◽  
Vol 12 (9) ◽  
pp. 647-651 ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Abolfazl Yazdanpanah ◽  
Amirbabak Abrishamkar ◽  
Fatholah Moztarzadeh ◽  
Arash Ramedani ◽  
...  
Keyword(s):  
Biological Activities ◽  
Silver Nps ◽  
Shape Controlled
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