Reactive Oxygen Species Impair the Function of CD90+ Hematopoietic Progenitors Generated from Human Pluripotent Stem Cells

Stem Cells ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Roger E. Rönn ◽  
Carolina Guibentif ◽  
Shobhit Saxena ◽  
Niels-Bjarne Woods
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Reactive Oxygen ◽  
Human Pluripotent Stem Cells ◽  
Oxygen Species ◽  
Hematopoietic Progenitors

scholarly journals Cell cycle‐coupled changes in the level of reactive oxygen species support the proliferation of human pluripotent stem cells

Stem Cells ◽  
2021 ◽  
Author(s):  
Julia S. Ivanova ◽  
Natalia A. Pugovkina ◽  
Irina E. Neganova ◽  
Irina V. Kozhukharova ◽  
Nikolay N. Nikolsky ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Reactive Oxygen ◽  
Human Pluripotent Stem Cells ◽  
Oxygen Species

scholarly journals Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells

2015 ◽  
Vol 31 (6) ◽  
pp. 279-286 ◽  
Author(s):  
Shigeo Saito ◽  
Ying-Chu Lin ◽  
Ming-Ho Tsai ◽  
Chang-Shen Lin ◽  
Yoshinobu Murayama ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Hypoxia Inducible Factors

scholarly journals OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†

2020 ◽  
Author(s):  
Yoshifumi Mori ◽  
Narumi Ogonuki ◽  
Ayumi Hasegawa ◽  
Mito Kanatsu-Shinohara ◽  
Atsuo Ogura ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Excision Repair ◽  
Point Mutations ◽  
Reactive Oxygen ◽  
Functional Screening ◽  
Oxygen Species ◽  
Self Renewal

Abstract Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, they induce DNA damage and are harmful to SSCs. However, little is known about how SSCs protect their genome during self-renewal. Here, we report that Ogg1 is essential for SSC protection against ROS. While cultured SSCs exhibited homologous recombination-based DNA double-strand break repair at levels comparable with those in pluripotent stem cells, they were significantly more resistant to hydrogen peroxide than pluripotent stem cells or mouse embryonic fibroblasts, suggesting that they exhibit high levels of base excision repair (BER) activity. Consistent with this observation, cultured SSCs showed significantly lower levels of point mutations than somatic cells, and showed strong expression of BER-related genes. Functional screening revealed that Ogg1 depletion significantly impairs survival of cultured SSCs upon hydrogen peroxide exposure. Thus, our results suggest increased expression of BER-related genes, including Ogg1, protects SSCs from ROS-induced damage.

scholarly journals Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species

Redox Biology ◽  
2021 ◽  
Vol 39 ◽  
pp. 101835
Author(s):  
Fei Chen ◽  
Run Su ◽  
Shiwei Ni ◽  
Yan Liu ◽  
Jiexiang Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Intestinal Stem Cells ◽  
Oxygen Species ◽  
Context Dependent

scholarly journals Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Kaihua Ji ◽  
Lianying Fang ◽  
Hui Zhao ◽  
Qing Li ◽  
Yang Shi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Ros Scavenging ◽  
Genes Encoding ◽  
Dna Strand

Unplanned exposure to radiation can cause side effects on high-risk individuals; meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding the tumor. Besides the direct radiation damage, most of the ionizing radiation- (IR-) induced injuries were caused by generation of reactive oxygen species (ROS). Human mesenchymal stem cells (hMSCs), which possess self-renew and multilineage differentiation capabilities, are a critical population of cells to participate in the regeneration of IR-damaged tissues. Therefore, it is imperative to search effective radioprotectors for hMSCs. This study was to demonstrate whether natural source ginger oleoresin would mitigate IR-induced injuries in human mesenchymal stem cells (hMSCs). We demonstrated that ginger oleoresin could significantly reduce IR-induced cytotoxicity, ROS generation, and DNA strand breaks. In addition, the ROS-scavenging mechanism of ginger oleoresin was also investigated. The results showed that ginger oleoresin could induce the translocation of Nrf2 to cell nucleus and activate the expression of cytoprotective genes encoding for HO-1 and NQO-1. It suggests that ginger oleoresin has a potential role of being an effective antioxidant and radioprotective agent.

scholarly journals Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells

2018 ◽  
Vol 9 (11) ◽  
Author(s):  
Hye-Ryeon Heo ◽  
Haengseok Song ◽  
Hye-Ryun Kim ◽  
Jeong Eun Lee ◽  
Young Gie Chung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Hematopoietic Progenitors

scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

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