Upregulation of FAM129B protects cardiomyocytes from hypoxia/reoxygenation‐induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ ARE activation

2022 ◽  
Author(s):  
Guangwei Zeng ◽  
Cheng Lian ◽  
Wei Li ◽  
Huixian An ◽  
Yang Han ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Hypoxia Reoxygenation

Naringin Inhibits TNF-α Induced Oxidative Stress and Inflammatory Response in HUVECs via Nox4/NF-κ B and PI3K/Akt Pathways

2014 ◽  
Vol 15 (12) ◽  
pp. 1173-1182 ◽  
Author(s):  
Wenshuang Li ◽  
Changyuan Wang ◽  
Jinyong Peng ◽  
Jing Liang ◽  
Yue Jin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response

scholarly journals Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia/reoxygenation HK2 Cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qian Gong ◽  
Zhi-ming Shen ◽  
Zhe Sheng ◽  
Shi Jiang ◽  
Sheng-lin Ge
Keyword(s):  
Cardiac Surgery ◽  
Inflammatory Response ◽  
Target Gene ◽  
Kidney Injury ◽  
Human Kidney ◽  
Luciferase Reporter ◽  
The Relationship ◽  
Hk2 Cells ◽  
Dual Luciferase Reporter Assay ◽  
Hypoxia Reoxygenation

AbstractThe occurrence of cardiac surgery-associated acute kidney injury (CSA-AKI) increases hospital stay and mortality. MicroRNAs has a crucial role in AKI. This objective of the current study is to explore the function of hsa-miR-494-3p in inflammatory response in human kidney tubular epithelial (HK2) cells with hypoxia/reoxygenation. According to KDIGO standard, patients after cardiac surgery with cardiopulmonary bypass were divided into two groups: AKI (n = 10) and non-AKI patients (n = 8). HK2 were raised in the normal and hypoxia/reoxygenation circumstances and mainly treated by overexpression ofmiR-494-3p and HtrA3. The relationship between miR-494-3p and HtrA3 was determined by dual-luciferase reporter assay. Our result showed that Hsa-miR-494-3p was elevated in the serum of patients with CSA-AKI, and also induced in hypoxic reoxygenated HK2 cells. Hsa-miR-494-3p also increased a hypoxia-reoxygenation induced inflammatory response in HK2 cells. Moreover, as a target gene of miR-494-3p, overexpression of HtrA3 downregulated the hypoxia-reoxygenation induced inflammatory response in HK2 cells. Overexpression of hsa-miR-494-3p-induced inflammatory response was inhibited by overexpression of HtrA3. Collectively, we identified that hsa-miR-494-3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by targeting HtrA3, which may suggest a possible role as a new therapeutic target for CSA-AKI.

scholarly journals E-cigarette fluids and aerosol residues cause oxidative stress and an inflammatory response in human keratinocytes and 3D skin models

2021 ◽  
pp. 105234
Author(s):  
Careen Khachatoorian ◽  
Wentai Luo ◽  
Kevin J. McWhirter ◽  
James F. Pankow ◽  
Prue Talbot
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Human Keratinocytes ◽  
3D Skin
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