scholarly journals EP14.23: Human long bone development in intrauterine growth restriction: in vivo analysis of the distal femoral epimetaphysis on prenatal MR imaging

2017 ◽  
Vol 50 ◽  
pp. 321-321
Author(s):  
U. Nemec ◽  
U. Nemec ◽  
P.C. Brugger ◽  
D. Bettelheim ◽  
D. Prayer
Keyword(s):  
Mr Imaging ◽  
Intrauterine Growth Restriction ◽  
Bone Development ◽  
Growth Restriction ◽  
Long Bone ◽  
Intrauterine Growth ◽  
In Vivo Analysis

Melatonin-MT1 signal is essential for endometrial decidualization

Reproduction ◽  
2021 ◽  
Author(s):  
Liyuan Cui ◽  
Feng Xu ◽  
Songcun Wang ◽  
Zhuxuan Jiang ◽  
Lu Liu ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Endometrial Stromal Cells ◽  
Reproductive Process ◽  
Intrauterine Growth ◽  
In Vivo Experiments ◽  
Adverse Pregnancy

Deficient decidualization of endometrial stromal cells (ESCs) can cause adverse pregnancy outcomes including miscarriage, intrauterine growth restriction and pre-eclampsia. Decidualization is regulated by multiple factors such as hormones and circadian genes. Melatonin, a circadian-controlled hormone, is reported to be important for various reproductive process, including oocyte maturation and placenta development. Its receptor, MT1, is considered to be related to intrauterine growth restriction and pre-eclampsia. However, the role of melatonin-MT1 signal in decidualization remains unknown. Here, we reported that decidual stromal cells from miscarriages displayed deficient decidualization with decreased MT1 expression. The expression level of MT1 is gradually increased with the process of decidualization induction in vitro. MT1 knockdown suppressed decidualization level, while overexpression of MT1 promoted the decidualization process. Moreover, changing MT1 level could regulate the expression of decidualization-related transcription factor FOXO1. Melatonin promoted decidualization and reversed the decidualization deficiency due to MT1 knockdown. Using in vitro and in vivo experiments, we further identified that lipopolysaccharide (LPS) could induce inflammation and decidualization resistance with downregulated MT1 expression, and melatonin could reverse the inflammation and decidualization resistance induced by LPS. These results suggested melatonin-MT1 signal might be essential for decidualization and might provide a novel therapeutic target for decidualization deficiency-associated pregnancy complications.

scholarly journals In Vivo Detection of Perinatal Brain Metabolite Changes in a Rabbit Model of Intrauterine Growth Restriction (IUGR)

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0131310 ◽  
Author(s):  
Rui V. Simões ◽  
Emma Muñoz-Moreno ◽  
Rodrigo J. Carbajo ◽  
Anna González-Tendero ◽  
Miriam Illa ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
In Vivo Detection ◽  
Brain Metabolite

Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs

1997 ◽  
Vol 272 (5) ◽  
pp. E877-E884 ◽  
Author(s):  
T. A. Davis ◽  
M. L. Fiorotto ◽  
D. G. Burrin ◽  
W. G. Pond ◽  
H. V. Nguyen
Keyword(s):  
Protein Synthesis ◽  
Intrauterine Growth Restriction ◽  
Plasma Insulin ◽  
Growth Restriction ◽  
Tissue Protein ◽  
Intrauterine Growth ◽  
Igf I ◽  
Tissue Protein Synthesis ◽  
Newborn Pigs

This study aimed to determine the effect of intrauterine growth restriction (IUGR) on the acute response of tissue protein synthesis to feeding in newborn pigs. Newborn pigs of sows fed either control or protein-restricted diets throughout gestation were designated C or IUGR, respectively. Both groups were either fasted for 9 h after birth or fed hourly 30 ml colostrum/kg body wt for 2.75 h after a 6-h fast. Fractional rates of tissue protein synthesis (Ks) were measured in vivo with a flooding dose of L-[4-3H]phenylalanine. Birth weight was reduced by 33% in IUGR pigs. IUGR had no effect on Ks in skeletal muscles, heart, liver, jejunum, or pancreas. Feeding stimulated tissue Ks similarly in C and IUGR pigs. Fasting plasma insulin concentrations and their rise with feeding were unaffected by IUGR. Plasma insulin-like growth factor I (IGF-I) concentrations were reduced by 42% in IUGR pigs and were not altered by feeding in either IUGR or C pigs. There were positive nonlinear relationships between tissue Ks and circulating concentrations of insulin. The results indicate that, in newborn pigs, tissue Ks are unaffected by IUGR, despite reduced plasma IGF-I concentrations. The efficiency with which nutrients stimulate tissue Ks is also not altered by IUGR, perhaps because the rise in plasma insulin concentrations with feeding is unaffected by IUGR.

Fetoplacental Oxygenation in an Intrauterine Growth Restriction Rat Model by Using Blood Oxygen Level–Dependent MR Imaging at 4.7 T

Radiology ◽  
2013 ◽  
Vol 269 (1) ◽  
pp. 122-129 ◽  
Author(s):  
Gihad E. Chalouhi ◽  
Marianne Alison ◽  
Benjamin Deloison ◽  
Rokhaya Thiam ◽  
Gwennhael Autret ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Rat Model ◽  
Intrauterine Growth Restriction ◽  
Blood Oxygen Level Dependent ◽  
Growth Restriction ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Intrauterine Growth

scholarly journals Human Long Bone Development in Vivo: Analysis of the Distal Femoral Epimetaphysis on MR Images of Fetuses

Radiology ◽  
2013 ◽  
Vol 267 (2) ◽  
pp. 570-580 ◽  
Author(s):  
Ursula Nemec ◽  
Stefan F. Nemec ◽  
Michael Weber ◽  
Peter C. Brugger ◽  
Gregor Kasprian ◽  
...  
Keyword(s):  
Bone Development ◽  
Long Bone ◽  
Mr Images ◽  
In Vivo Analysis

In vivo assessment of placental elasticity in intrauterine growth restriction by shear-wave elastography

2017 ◽  
Vol 97 ◽  
pp. 16-20 ◽  
Author(s):  
Hatice Arioz Habibi ◽  
Ebru Alici Davutoglu ◽  
Sedat Giray Kandemirli ◽  
Mine Aslan ◽  
Aysegul Ozel ◽  
...  
Keyword(s):  
Shear Wave ◽  
Intrauterine Growth Restriction ◽  
Shear Wave Elastography ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
In Vivo Assessment

Pathological features of the sequence in pregnant women with delayed fetal growth

2019 ◽  
pp. 50-54
Author(s):  
V.O. Golyanovskiy ◽  
◽  
Ye.O. Didyk ◽  
Keyword(s):  
Pregnant Women ◽  
Intrauterine Growth Restriction ◽  
Normal Development ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Control Group ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Infection And Inflammation

Pregnant women with intrauterine growth restriction (IUGR) have an increased risk of adverse perinatal and long-term complications compared with the birth of children with normal body weight. Thus, IUGR is one of the main challenges for the global health system, especially in poor and developing countries. Morpho-functional studies of the placentas help in determining the causes of IUGR, and therefore, timely prevent complications in pregnant women with IUGR. The objective: The purpose of this study is to investigate various morphometric and pathomorphological changes in the placenta, including inflammatory, in cases of IUGR, and to establish a correlation of these results with the etiology and complications for the fetus. Materials and methods. In the current study, 54 placentas of the fetuses with IUGR (the main group) were compared with 50 placentas of the fetuses with normal development (control group). The criteria for the inclusion of IUGR were gestational age more than 30 weeks and all fetuses with a weight less than 10th percentile for this period of pregnancy. The placenta material was studied pathomorphologically with laboratory screening for infection and inflammation. Similarly, the results were determined for placentas of the fetuses with normal development compared to placentas with IUGR. Results. The placenta study showed the presence of calcification in the case of IUGR, as well as in the case of prolonged pregnancy. However, calcification of the placenta in the case of IUGR was more progressive compared with placenta in the normal pregnancy. In addition, the presence of intrauterine infection and inflammation was observed, which could also lead to an adverse outcome for the further progression of pregnancy with IUGR. Conclusion. A comparative macro- and microscopic pathomorphological study of the placentas in the two groups has shown a significant increase in the pathological changes in all the anatomical structures of the fetuses with IUGR. Key words: Intrauterine growth restriction (IUGR), fetal weight, pathomorphological changes of the placenta.

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