The Mouse SHIP2 (Inppl1) Gene: Complementary DNA, Genomic Structure, Promoter Analysis, and Gene Expression in the Embryo and Adult Mouse

Background: Liver disease is more severe in HDV+HBV co-infected patients than HBV infected patients which seems to be related to differences in the expression of genes and other factors such as MicroRNAs (miRNAs). The aim of this study was to investigate miR-222 expression in HBV infected patients in comparison with HDV+HBV co-infected patients. Methods: First, total RNA was extracted from the serum samples and then, complementary DNA (cDNA) was produced using cDNA synthesis kit. Finally, miR-222 gene expression was measured using U6 as the internal control by quantitative PCR (qPCR). Results: The level of miR-222 expression in HDV+HBV co-infected samples was significantly up regulated. The fold change of the miR-222 expression between two groups was 3.3 (95% CI; 0.011- 17.63) with p<0.001. Conclusion: The expression of miR-222 was higher in HBV+HDV co-infected patients than HBV infected patients. Further studies should be conducted to confirm whether miR-222 can be a biomarker for prognosis of severe liver diseases.

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Differential Gene Expression Profiling of Vocal Fold Polyps and Reinke's Edema by Complementary DNA Microarray

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940611500910 ◽

2006 ◽

Vol 115 (9) ◽

pp. 703-714 ◽

Cited By ~ 35

Author(s):

Suzy M. Duflo ◽

Susan L. Thibeault ◽

Wenhua Li ◽

Marshall E. Smith ◽

Goetz Schade ◽

...

Keyword(s):

Gene Expression ◽

Gene Expression Profiling ◽

Differential Gene Expression ◽

Dna Microarray ◽

Expression Profiling ◽

Vocal Fold ◽

Complementary Dna ◽

Reinke’S Edema ◽

Differential Gene

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The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses

Animal Health Research Reviews ◽

10.1079/ahr200496 ◽

2004 ◽

Vol 5 (2) ◽

pp. 125-143 ◽

Cited By ~ 17

Author(s):

Marie-Claude St-Louis ◽

Mihaela Cojocariu ◽

Denis Archambault

Keyword(s):

Gene Expression ◽

Human Immunodeficiency Virus ◽

Genomic Structure ◽

Bovine Immunodeficiency Virus ◽

Striking Similarity ◽

Wasting Syndrome ◽

Visna Virus ◽

Immunodeficiency Virus ◽

Viral Genes ◽

Molecular Aspects

AbstractBovine immunodeficiency virus (BIV) was first isolated in 1969 from a cow, R-29, with a wasting syndrome. The virus isolated induced the formation of syncytia in cell cultures and was structurally similar to maedi-visna virus. Twenty years later, it was demonstrated that the bovine R-29 isolate was indeed a lentivirus with striking similarity to the human immunodeficiency virus. Like other lentiviruses, BIV has a complex genomic structure characterized by the presence of several regulatory/accessory genes that encode proteins, some of which are involved in the regulation of virus gene expression. This manuscript aims to review biological and, more particularly, molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins, in comparison with those of other lentiviruses.

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