Structural and Functional Regulation of Desmosomes

2007 ◽  
pp. 160-177
Author(s):  
Spiro Getsios ◽  
Lisa M. Godsel ◽  
Kathleen J. Green
Keyword(s):  
Functional Regulation

Lead-free organic–inorganic hybrid semiconductors and NLO switches tuned by dimensional design

2021 ◽  
Vol 9 (12) ◽  
pp. 4338-4343
Author(s):  
Hong-Yi Shen ◽  
Lei He ◽  
Ping-Ping Shi ◽  
Qiong Ye
Keyword(s):  
Hybrid Materials ◽  
Lead Free ◽  
Inorganic Hybrid ◽  
Hybrid Semiconductors ◽  
Functional Regulation

Two organic–inorganic hybrid materials exhibit functional regulation by introducing homochiral cations and different reagent ratios.

scholarly journals Novel insights into the m6A-RNA methyltransferase METTL3 in cancer

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yiqing Cai ◽  
Rui Feng ◽  
Tiange Lu ◽  
Xiaomin Chen ◽  
Xiangxiang Zhou ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Human Cancer ◽  
Rna Modification ◽  
Rapid Progression ◽  
Antitumor Therapy ◽  
Promoting Effect ◽  
Methyl Group ◽  
Group Transfer ◽  
Functional Regulation ◽  
Methyl Group Transfer

AbstractN6-methyladenosine (m6A) is a prevalent internal RNA modification in higher eukaryotic cells. As the pivotal m6A regulator, RNA methyltransferase-like 3 (METTL3) is responsible for methyl group transfer in the progression of m6A modification. This epigenetic regulation contributes to the structure and functional regulation of RNA and further promotes tumorigenesis and tumor progression. Accumulating evidence has illustrated the pivotal roles of METTL3 in a variety of human cancers. Here, we systemically summarize the interaction between METTL3 and RNAs, and illustrate the multiple functions of METTL3 in human cancer. METLL3 is aberrantly expressed in a variety of tumors. Elevation of METTL3 is usually associated with rapid progression and poor prognosis of tumors. On the other hand, METTL3 may also function as a tumor suppressor in several cancers. Based on the tumor-promoting effect of METTL3, the possibility of applying METTL3 inhibitors is further discussed, which is expected to provide novel insights into antitumor therapy.

scholarly journals Functional Regulation of Protein Synthesis in the Rat Parotid Gland

1971 ◽  
Vol 246 (12) ◽  
pp. 3879-3884 ◽  
Author(s):  
Leo M. Sreebny ◽  
Dorthea A. Johnson ◽  
Murray R. Robinovitch
Keyword(s):  
Protein Synthesis ◽  
Parotid Gland ◽  
Rat Parotid Gland ◽  
Functional Regulation ◽  
Rat Parotid

scholarly journals Localization of Receptors for Sex Steroids and Pituitary Hormones in the Female Genital Duct throughout the Reproductive Cycle of a Viviparous Gymnophiona Amphibian, Typhlonectes compressicauda

Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 2
Author(s):  
Claire Brun ◽  
Jean-Marie Exbrayat ◽  
Michel Raquet
Keyword(s):  
Reproductive Cycle ◽  
Sex Steroids ◽  
Morphological Changes ◽  
Progesterone Receptors ◽  
Pituitary Hormones ◽  
Prolactin Receptors ◽  
Functional Regulation ◽  
Specific Receptors ◽  
Immunohistochemical Methods ◽  
Female Genital

Reproduction in vertebrates is controlled by the hypothalamo-pituitary-gonadal axis, and both the sex steroid and pituitary hormones play a pivotal role in the regulation of the physiology of the oviduct and events occurring within the oviduct. Their hormonal actions are mediated through interaction with specific receptors. Our aim was to locate α and β estrogen receptors, progesterone receptors, gonadotropin and prolactin receptors in the tissues of the oviduct of Typhlonectes compressicauda (Amphibia, Gymnophiona), in order to study the correlation between the morphological changes of the genital tract and the ovarian cycle. Immunohistochemical methods were used. We observed that sex steroids and pituitary hormones were involved in the morpho-functional regulation of oviduct, and that their cellular detection was dependent on the period of the reproductive cycle.

The effects of phosphorylation on the functional regulation of an expressed recombinant human dopamine transporter

1996 ◽  
Vol 216 (2) ◽  
pp. 133-136 ◽  
Author(s):  
N.S. Vrindavanam ◽  
P. Arnaud ◽  
J.X. Ma ◽  
S. Altman-Hamamdzic ◽  
N.P. Parratto ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Functional Regulation

scholarly journals Post-Translational Modification and Subcellular Compartmentalization: Emerging Concepts on the Regulation and Physiopathological Relevance of RhoGTPases

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1990
Author(s):  
Inmaculada Navarro-Lérida ◽  
Miguel Sánchez-Álvarez ◽  
Miguel Ángel del Pozo
Keyword(s):  
Rho Gtpases ◽  
Rho Gtpase ◽  
Protein Complexes ◽  
Specific Protein ◽  
Cell Polarization ◽  
Small Gtpase ◽  
Post Translational Modification ◽  
Functional Regulation ◽  
Subcellular Compartmentalization ◽  
Cellular Compartments

Cells and tissues are continuously exposed to both chemical and physical stimuli and dynamically adapt and respond to this variety of external cues to ensure cellular homeostasis, regulated development and tissue-specific differentiation. Alterations of these pathways promote disease progression—a prominent example being cancer. Rho GTPases are key regulators of the remodeling of cytoskeleton and cell membranes and their coordination and integration with different biological processes, including cell polarization and motility, as well as other signaling networks such as growth signaling and proliferation. Apart from the control of GTP–GDP cycling, Rho GTPase activity is spatially and temporally regulated by post-translation modifications (PTMs) and their assembly onto specific protein complexes, which determine their controlled activity at distinct cellular compartments. Although Rho GTPases were traditionally conceived as targeted from the cytosol to the plasma membrane to exert their activity, recent research demonstrates that active pools of different Rho GTPases also localize to endomembranes and the nucleus. In this review, we discuss how PTM-driven modulation of Rho GTPases provides a versatile mechanism for their compartmentalization and functional regulation. Understanding how the subcellular sorting of active small GTPase pools occurs and what its functional significance is could reveal novel therapeutic opportunities.

scholarly journals Neotropical coastal lagoons: an appraisal of their biodiversity, functioning, threats and conservation management

2008 ◽  
Vol 68 (4 suppl) ◽  
pp. 967-981 ◽  
Author(s):  
FA. Esteves ◽  
A. Caliman ◽  
JM. Santangelo ◽  
RD. Guariento ◽  
VF. Farjalla ◽  
...  
Keyword(s):  
Anthropogenic Impacts ◽  
Coastal Lagoons ◽  
Conservation Strategies ◽  
Human Occupation ◽  
Species Introduction ◽  
Government Officials ◽  
Private Companies ◽  
Aquatic Biodiversity ◽  
Scenic Beauty ◽  
Functional Regulation

Neotropical coastal lagoons (NCL) are human-dominated ecosystems. Their distribution along densely populated coastal areas of developing countries makes these systems among the most threatened in the world. Here, we summarize some aspects of the causes and consequences of NCL biodiversity, their functioning, their importance to the surrounding populations, their fragility, and their responses to local and global anthropogenic impacts and the challenges that Neotropical countries face in conserving these systems. Although still scarce and geographically concentrated, a growing body of studies has shown that NCLs are physiographically diversified systems, which harbor a considerable and particular proportion of the Neotropical inland aquatic biodiversity. Despite the fact that coastal lagoons are ecotones that are intricately connected to surrounding environments, they develop mechanisms for structural and functional regulation, which confer to these systems higher productivity and carrying capacities than surrounding ecosystems. Such traits attract residential developments and subsidize local traditional populations with important economic and aesthetic ecosystem revenues such as fisheries and scenic beauty. However, the disorganized human occupation around NCLs are causing profound impacts such as eutrophication, salinization, exotic species introduction, as well as other effects, which are ultimately imposing major habitat degradations and biodiversity extirpations in NCLs. We argue that interdisciplinary conservation strategies, which integrate scientific expertise, government officials, private companies and the general public, are the most likely to overcome the geographic and economic obstacles to NCL conservation.

scholarly journals A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft

2015 ◽  
Vol 87 (5) ◽  
pp. 984-995 ◽  
Author(s):  
Daniel Baron ◽  
Gérard Ramstein ◽  
Mélanie Chesneau ◽  
Yann Echasseriau ◽  
Annaick Pallier ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Gene Signature ◽  
Common Gene ◽  
Functional Regulation
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