Nanomechanical Function Arising from the Complex Architecture of Dendronized Helical Polymers

2013 ◽  
pp. 345-362 ◽  
Author(s):  
Jonathan G. Rudick
Keyword(s):  
Helical Polymers ◽  
Complex Architecture

RNA polymerase: Preparation and structural analysis of helical polymers

1984 ◽  
Vol 42 ◽  
pp. 152-153
Author(s):  
E. Loren Buhle ◽  
Pamela Rew ◽  
Ueli Aebi
Keyword(s):  
Structural Analysis ◽  
Rna Polymerase ◽  
Molecular Level ◽  
X Ray Diffraction ◽  
Helical Polymers ◽  
X Ray ◽  
E Coli ◽  
The Past ◽  
Ordered Arrays ◽  
Low Ionic Strength

While DNA-dependent RNA polymerase represents one of the key enzymes involved in transcription and ultimately in gene expression in procaryotic and eucaryotic cells, little progress has been made towards elucidation of its 3-D structure at the molecular level over the past few years. This is mainly because to date no 3-D crystals suitable for X-ray diffraction analysis have been obtained with this rather large (MW ~500 kd) multi-subunit (α2ββ'ζ). As an alternative, we have been trying to form ordered arrays of RNA polymerase from E. coli suitable for structural analysis in the electron microscope combined with image processing. Here we report about helical polymers induced from holoenzyme (α2ββ'ζ) at low ionic strength with 5-7 mM MnCl2 (see Fig. 1a). The presence of the ζ-subunit (MW 86 kd) is required to form these polymers, since the core enzyme (α2ββ') does fail to assemble into such structures under these conditions.

10-step Synthesis of 20-nor-Salvinorin A by Dynamic Strategic Bond Analysis

2017 ◽  
Author(s):  
Jeremy Roach ◽  
Yusuke Sasano ◽  
Cullen Schmid ◽  
Saheem Zaidi ◽  
Vsevolod Katritch ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Opioid Receptors ◽  
Structural Modification ◽  
High Selectivity ◽  
Therapeutic Potential ◽  
Salvinorin A ◽  
High Affinity ◽  
Plant Metabolite ◽  
Complex Architecture ◽  
Property Modification

Salvinorin A (SalA) is a plant metabolite that agonizes the human <i>kappa</i>-opioid receptor (κ-OR) with high affinity and high selectivity over <i>mu- </i>and <i>delta-</i>opioid receptors. Its therapeutic potential has stimulated extensive semi-synthetic studies and total synthesis campaigns. However, structural modification of SalA has been complicated by its instability, and efficient total synthesis has been frustrated by its dense, complex architecture. Treatment of strategic bonds in SalA as dynamic and dependent on structural perturbation enabled the identification of an efficient retrosynthetic pathway. Here we show that deletion of C20 simultaneously stabilizes the SalA skeleton, simplifies its synthesis and retains its high affinity and selectivity for the κ-OR. The resulting 10-step synthesis now opens the SalA scaffold to deep-seated property modification.

SOME SPECIFIC FEATURES OF DRILLING COMPLEX ARCHITECTURE WELLS IN OIL RESERVOIRS OF TYUMEN FORMATION OF SYMORYAKHSKOYE FIELD

2020 ◽  
pp. 32-37
Author(s):  
V.V. Yudchits ◽  
◽  
R.E. Litovar ◽  
S.V. Babenkov ◽  
A.E. Balakina ◽  
...  
Keyword(s):  
Oil Reservoirs ◽  
Complex Architecture

scholarly journals Dinuclear Species versus Zigzag or Helical Polymers in Palladium, Zinc, and Copper Complexes with Ditopic Bis(pyrazolyl)methane Ligands

2013 ◽  
Vol 2013 (35) ◽  
pp. 5930-5930
Author(s):  
Gema Durá ◽  
M. Carmen Carrión ◽  
Félix A. Jalón ◽  
Blanca R. Manzano ◽  
Ana M. Rodríguez
Keyword(s):  
Copper Complexes ◽  
Helical Polymers

Synthesis of Helical Polymers by Polycondensation of Diboronic Acid and Chiral Tetrols

1995 ◽  
Vol 24 (7) ◽  
pp. 603-604 ◽  
Author(s):  
Masafumi Mikami ◽  
Seiji Shinkai
Keyword(s):  
Helical Polymers
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