Mannich Base Ligands as Versatile Platforms for SMMs

2018 ◽  
pp. 101-161 ◽  
Author(s):  
Enrique Colacio
Keyword(s):  
Mannich Base

Microwave-assisted Synthesis of Polymethoxychalcone Mannich Bases and Their Antiproliferative Activity

2019 ◽  
Vol 16 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Peipei Han ◽  
Wenhua Zhou ◽  
Mingxia Chen ◽  
Qiuan Wang
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Mannich Base ◽  
Cancer Cell Lines ◽  
Secondary Amines ◽  
Conventional Heating ◽  
Microwave Assisted ◽  
Ic50 Values ◽  
Antiproliferative Activities

A series of eight polymethoxychalcone Mannich base derivatives 2a-2h was synthesized via the microwave-assisted Mannich reaction of natural product 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (1) with various secondary amines and formaldehyde. Compared to conventional heating method (80°C), the microwave-assisted method (700W, 65°C) is efficient with short reaction time (0.5-1 h) and good yields (74-88%). The antiproliferative activities of eight Mannich base derivatives were evaluated in vitro on a panel of three human cancer cell lines (Hela, HCC1954 and SK-OV-3) by CCK-8 assay. The results showed that all of the Mannich base derivatives exhibited potential antiproliferative activities on tested cancer cell lines with the IC50 values of 9.13-48.51 µM. Some active compounds exhibited more activity as compared to positive control cis-Platin. Among them, compound 2b revealed to have the strongest antiproliferative activity against all the three cancer cell lines with IC50 values ranging from 9.13 to 11.24 µM.

Design and synthesis of mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

2021 ◽  
pp. 113646
Author(s):  
Iván Beltran-Hortelano ◽  
Richard L. Atherton ◽  
Mercedes Rubio-Hernández ◽  
Julen Sanz-Serrano ◽  
Verónica Alcolea ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Mannich Base ◽  
Design And Synthesis ◽  
Lead Compounds

scholarly journals Recent advances and prospects in the Zn-catalysed Mannich reaction

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9098-9111
Author(s):  
Salahudeen Shamna ◽  
C. M. A. Afsina ◽  
Rose Mary Philip ◽  
Gopinathan Anilkumar
Keyword(s):  
Carbonyl Compound ◽  
Secondary Amine ◽  
Mannich Reaction ◽  
Mannich Base ◽  
Mannich Reactions ◽  
Recent Advances ◽  
Primary Secondary Amine

Amino alkylation of an acidic α-proton of a carbonyl by formaldehyde and a primary/secondary amine or ammonia, affording a β-amino-carbonyl compound also known as a Mannich base is a valuable reaction. We focus on recent advances in Zn catalysed Mannich reactions.

Synthesis and Antiproliferative Activity of Prenylated Chalcone Mannich Base Derivatives

2021 ◽  
Author(s):  
Liang Su ◽  
Ke-Xiong Liu ◽  
Pei-Pei Han ◽  
Qiu-An Wang
Keyword(s):  
Antiproliferative Activity ◽  
Mannich Base ◽  
Prenylated Chalcone

Chitosan oligosaccharide-N-chlorokojic acid mannich base polymer as a potential antibacterial material

2018 ◽  
Vol 182 ◽  
pp. 225-234 ◽  
Author(s):  
Xiaoli Liu ◽  
Wenshui Xia ◽  
Qixing Jiang ◽  
Peipei Yu ◽  
Lin Yue
Keyword(s):  
Mannich Base ◽  
Chitosan Oligosaccharide ◽  
Base Polymer ◽  
Antibacterial Material

scholarly journals Mannich Base as Corrosion Inhibitors for N80 Steel in a CO2 Saturated Solution Containing 3 wt % NaCl

Materials ◽  
2019 ◽  
Vol 12 (3) ◽  
pp. 449 ◽  
Author(s):  
Mingjin Tang ◽  
Jianbo Li ◽  
Zhida Li ◽  
Luoping Fu ◽  
Bo Zeng ◽  
...  
Keyword(s):  
Corrosion Inhibitor ◽  
Corrosion Inhibition ◽  
Steel Sheet ◽  
Mannich Base ◽  
Saturated Solution ◽  
Control Group ◽  
Protective Film ◽  
Blank Control Group ◽  
Inhibition Effect ◽  
N80 Steel

In this paper, a corrosion inhibitor containing nitrogen atoms and a conjugated π bond was synthesised, and its final product synthesised by the optimal conditions of the orthogonal test results is named multi-mannich base (MBT). The corrosion inhibition effect on the N80 steel sheet of the corrosion inhibitor was evaluated in a CO2 saturated solution containing 3 wt % NaCl; the corrosion rate was 0.0446 mm/a and the corrosion inhibition rate was 90.4%. Through electrochemical and adsorption theory study, MBT is a mixed corrosion inhibitor that mainly shows cathode suppression capacity. The adsorption of MBT on the surface of the steel sheet follows the Langmuir adsorption isotherm; it can be spontaneously adsorbed on the surface of the N80 steel sheet, which has a good corrosion inhibition effect. The surface of the N80 steel sheet was microscopically characterised by atomic force microscope (AFM). It can be seen from the results that the N80 steel sheet with MBT added is significantly different from the blank control group; the surface of the steel sheet is relatively smooth, indicating that MBT forms an effective protective film on the surface of N80 steel, which inhibits the steel sheet.

Chemistry of Phosphorus Ylides. Part 27. Metal Complexes of 4-hydroxyquinaldine, its Mannich Base and Phosphonium Ylide

2009 ◽  
Vol 2009 (5) ◽  
pp. 277-282 ◽  
Author(s):  
Fouad Soliman ◽  
Ibrahim Abd-Ellah ◽  
Soher Maigali ◽  
Gamal Abd-El-Naim
Keyword(s):  
Nitrogen Atom ◽  
Metal Complexes ◽  
Mannich Base ◽  
Phosphorus Ylides ◽  
Physicochemical Data

The reaction of Hg2+,Cd2+,Co2+, and Ni2+ ions with 1 mol of the ligands 2-methylquinoline-4-ol,3[(diethylamino)methyl]-2-methylquinoline-4-ol, and methyl-3-(4-hyrdoxy-2-methylquinoline-3-yl)-2-(triphenylphosphoranylidene)propanoate, has been investigated to give the corresponding 1:1 metal:ligand complexes. Reaction of 2 mol of the ligand gave the corresponding 1:2 metal:ligand complexes. The coordination takes place only through the quinoline nitrogen atom. The spectroscopic and the physicochemical data of the new metal complexes are discussed.

Synthesis and biological evaluation of cyclopenten-1-one Mannich base oxovanadium compound

2009 ◽  
Vol 19 (9) ◽  
pp. 1162-1173 ◽  
Author(s):  
Juan Tian ◽  
Dongliu Li ◽  
Fengying Zhai ◽  
Xiaohong Wang ◽  
Rui Li
Keyword(s):  
Mannich Base ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and characterization of Mannich base monophenolate lanthanide complexes and their application in ring-opening polymerization of ε-caprolactone

2016 ◽  
Vol 30 (6) ◽  
pp. 458-464 ◽  
Author(s):  
Ling Peng ◽  
Jing Zhao ◽  
Li-Jun Wang ◽  
Xian Tao ◽  
Yu-Long Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Lanthanide Complexes ◽  
Mannich Base ◽  
Ring Opening Polymerization ◽  
Synthesis And Characterization
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