Survival Signaling

2007 ◽  
pp. 169-206 ◽  
Author(s):  
Carlos Garcia-Echeverria
Keyword(s):  
Survival Signaling

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signaling☆

2006 ◽  
Vol 312 (8) ◽  
pp. 1289-1298 ◽  
Author(s):  
M LESKINEN ◽  
H HEIKKILA ◽  
M SPEER ◽  
J HAKALA ◽  
M LAINE ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Survival Signaling ◽  
Muscle Cell Apoptosis ◽  
Mast Cell Chymase

scholarly journals 4-Hydroxy-3-Methoxybenzoic Acid Methyl Ester: A Curcumin Derivative Targets Akt/NFκB Cell Survival Signaling Pathway: Potential for Prostate Cancer Management

Neoplasia ◽  
2003 ◽  
Vol 5 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Addanki P. Kumar ◽  
Gretchen E. Garcia ◽  
Rita Ghosh ◽  
Rajendran V. Rajnarayanan ◽  
William L. Alworth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methyl Ester ◽  
Cell Survival ◽  
Acid Methyl Ester ◽  
Cancer Management ◽  
Acid Methyl ◽  
Survival Signaling ◽  
Prostate Cancer Management ◽  
Curcumin Derivative ◽  
Methoxybenzoic Acid

scholarly journals Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells

2013 ◽  
Vol 93 (5) ◽  
pp. 713-721 ◽  
Author(s):  
Laurent Sabbagh ◽  
Daniela Andreeva ◽  
Geneviève Dubeau Laramée ◽  
N. A. Eustache Oussa ◽  
Déborah Lew ◽  
...  
Keyword(s):  
T Cells ◽  
Specific Protein ◽  
Tnf Receptor ◽  
Associated Factor ◽  
Survival Signaling

P0111. Exogenous nitric oxide donors exhibit differential inhibition of NF-κB survival signaling dependent on strong vs. weak kinetic activators

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 53
Author(s):  
Joseph A. Lupica ◽  
Joseph A. Bauer ◽  
Zhuo Tang ◽  
Daniel J. Lindner ◽  
Joseph A. DiDonato
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donors ◽  
Differential Inhibition ◽  
Survival Signaling ◽  
Exogenous Nitric Oxide

CSIG-11. KINASE-DIRECTED INHIBITION OF PYRIMIDINE BIOSYNTHESIS IN PTEN-DEFICIENT GLIOBLASTOMA

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi35-vi35
Author(s):  
Pranjal Sarma ◽  
Kelli N Ennis ◽  
Catherine A Behrmann ◽  
Collin Wetzel ◽  
Biplab Dasgupta ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tyrosine Kinases ◽  
Pyrimidine Biosynthesis ◽  
Flux Analysis ◽  
Glioblastoma Cells ◽  
Nucleotide Biosynthesis ◽  
Pten Loss ◽  
Frontline Treatment ◽  
Survival Signaling ◽  
Cytotoxic Responses

Abstract Targeting pyrimidine biosynthesis has been a mainstay of chemotherapy in oncology, including frontline treatment of pancreatic, breast, and colorectal carcinomas. In glioblastoma, the targeting pyrimidine biosynthesis is a promising emerging approach for counteracting the effects of PTEN-deficiency in glioblastoma. PTEN loss triggers the activation of mTORC1, which in turn phosphorylates and activates the ribosomal protein kinases S6K1 and S6K2. We have previously shown that combination treatment of inhibitors targeting S6K1 and the TYRO3-AXL-MERTK receptor tyrosine kinases (TAM-RTKs) triggers cytotoxic responses in PTEN-deficient glioblastoma cells. Here we show brain-penetrant inactivation of S6K1 and TAM-RTKs using the S6K1 inhibitor LY-2584702 and the TAM-RTK inhibitor BMS-777607, which reduced glioblastoma tumor growth. Pharmacogenetic analysis of signal transduction indicated a key role for S6K2 in sustaining survival signaling in PTEN-deficient glioblastoma cells. Steady-state metabolomics revealed that combined inactivation of S6K1 and TAM-RTKs resulted in decreased nucleotide biosynthesis, and flux analysis indicated reduced flux of glucose to pyrimidines. Altogether the results indicate a kinase-directed therapeutic strategy for targeting S6K1 and TAM-RTKs to reduce pyrimidine biosynthesis and glioblastoma tumor growth.

Akt-GSK3β Pro-survival Signaling Pathway in Cerebral Ischemic Injury

2017 ◽  
pp. 269-272
Author(s):  
W. Zhang ◽  
R.A. Stetler ◽  
J. Chen
Keyword(s):  
Signaling Pathway ◽  
Ischemic Injury ◽  
Survival Signaling ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling

2004 ◽  
Vol 315 (1) ◽  
pp. 160-165 ◽  
Author(s):  
Anne K Jonassen ◽  
Ole D Mjøs ◽  
Michael N Sack
Keyword(s):  
Cell Survival ◽  
P70s6 Kinase ◽  
Survival Signaling
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