New Developments in Ultrasonic Adaptive Focusing Through the Human Skull: Application to Non Invasive Brain Therapy and Imaging

2004 ◽  
pp. 447-456
Author(s):  
M. Tanter ◽  
J.-F. Aubry ◽  
M. Pernot ◽  
J.-L. Thomas ◽  
F. Vignon ◽  
...  
Keyword(s):  
New Developments ◽  
Human Skull ◽  
Non Invasive

scholarly journals Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

2021 ◽  
Vol 22 (22) ◽  
pp. 12549
Author(s):  
Nkune Williams Nkune ◽  
Heidi Abrahamse
Keyword(s):  
Photodynamic Therapy ◽  
Metastatic Melanoma ◽  
Water Solubility ◽  
Three Dimensional ◽  
New Developments ◽  
Non Invasive ◽  
Promising Strategy ◽  
Skin Malignancy ◽  
Therapeutic Outcomes ◽  
D Cell

Metastatic melanoma (MM) is a skin malignancy arising from melanocytes, the incidence of which has been rising in recent years. It poses therapeutic challenges due to its resistance to chemotherapeutic drugs and radiation therapy. Photodynamic therapy (PDT) is an alternative non-invasive modality that requires a photosensitizer (PS), specific wavelength of light, and molecular oxygen. Several studies using conventional PSs have highlighted the need for improved PSs for PDT applications to achieve desired therapeutic outcomes. The incorporation of nanoparticles (NPs) and targeting moieties in PDT have appeared as a promising strategy to circumvent various drawbacks associated with non-specific toxicity, poor water solubility, and low bioavailability of the PSs at targeted tissues. Currently, most studies investigating new developments rely on two-dimensional (2-D) monocultures, which fail to accurately mimic tissue complexity. Therefore, three-dimensional (3-D) cell cultures are ideal models to resemble tumor tissue in terms of architectural and functional properties. This review examines various PS drugs, as well as passive and active targeted PS nanoparticle-mediated platforms for PDT treatment of MM on 2-D and 3-D models. The overall findings of this review concluded that very few PDT studies have been conducted within 3-D models using active PS nanoparticle-mediated platforms, and so require further investigation.

Real time contact-free and non-invasive tracking of the human skull: first light and initial validation

2013 ◽  
Author(s):  
Floris Ernst ◽  
Ralf Bruder ◽  
Tobias Wissel ◽  
Patrick Stüber ◽  
Benjamin Wagner ◽  
...  
Keyword(s):  
Real Time ◽  
Human Skull ◽  
Non Invasive ◽  
Initial Validation ◽  
Contact Free

SESSION 24: NEW DEVELOPMENTS IN NON-INVASIVE EMBRYO ASSESSMENT

2012 ◽  
Vol 27 (suppl 2) ◽  
pp. ii36-ii36 ◽  
Author(s):  
M. Meseguer
Keyword(s):  
New Developments ◽  
Non Invasive

scholarly journals The role of robots in the improving work of nurses

2019 ◽  
Vol 18 (3) ◽  
pp. 174-182
Author(s):  
Łukasz Blechar ◽  
Patrycja Zalewska
Keyword(s):  
Animal Therapy ◽  
New Developments ◽  
Personal Involvement ◽  
Non Invasive ◽  
Current Trends ◽  
Current State ◽  
The Social ◽  
The World ◽  
Future Of Nursing

AbstractIntroduction. Currently we observe a change in the labor market. It is caused by the new developments in the field of artificial Intelligence.Aim. We would like to present current trends affecting the work of nurses and midwives around the world in order to raise the social awareness of these changes among Polish healthcare workers. Moreover, we want to emphasize the fact that it is necessary to involve them as the stakeholders in the ongoing discussions and research projects in order to better understand their needs and expectations.Discussion. The article revolves around the current state of technology. We begin by outlining the framework of the perceived changes in the nurses’ structures and tasks around the world. Then we provide the examples of a variety of robots already executing those tasks. We start with the robots whose purpose is the elimination of simple, routine activities such as TUG or HOMER. After doing so, we move on to possible solutions how to eliminate the need for personal involvement in invasive (such as BloodBot) and non-invasive procedures (CLARA). We finish by introducing the machines used to replicate animal therapy, which can be used to treat patients who have difficulties with communicating their needs.Conclusions. We would like to present the future of nursing closely related to machines. We want to emphasize the element of complementarity of this relation and the fact that performing some tasks by robots is not connected with replacing people, but rather with enabling them to shift their focus from the performance of arduous duties to spending more time on empathic work with the patient.

Non-invasive beat-to-beat blood pressure monitoring: new developments

2003 ◽  
Vol 8 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Gianfranco Parati ◽  
Guido Ongaro ◽  
Grzegorz Bilo ◽  
Fabio Glavina ◽  
Paolo Castiglioni ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
New Developments ◽  
Non Invasive

New perspectives of hyperspectral imaging for clinical research

NIR news ◽  
2021 ◽  
Vol 32 (3-4) ◽  
pp. 5-13
Author(s):  
Johannes D Pallua ◽  
Andrea Brunner ◽  
Bernhard Zelger ◽  
Christian W Huck ◽  
Michael Schirmer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Data Analysis ◽  
Clinical Research ◽  
Hyperspectral Imaging ◽  
Tissue Blood Flow ◽  
Clinical Use ◽  
New Developments ◽  
Non Invasive ◽  
Invasive Method

New developments in instrumentation and data analysis have further improved the perspectives of hyperspectral imaging in clinical use. Thus, hyperspectral imaging can be considered as “Next Generation Imaging” for future clinical research. As a contactless, non-invasive method with short process times of just a few seconds, it quantifies predefined substance classes. Results of hyperspectral imaging may support the detection of carcinomas and the classification of different tissue structures as well as the assessment of tissue blood flow. Taken together, this method combines the principle of spectroscopy with imaging using conventional visual cameras. Compared to other optical imaging methods, hyperspectral imaging also analyses deeper layers of tissue.

scholarly journals Emerging concepts in non-invasive monitoring of Crohn’s disease

2018 ◽  
Vol 11 ◽  
pp. 175628481876907 ◽  
Author(s):  
Wojciech Marlicz ◽  
Karolina Skonieczna-Żydecka ◽  
Konstantinos John Dabos ◽  
Igor Łoniewski ◽  
Anastasios Koulaouzidis
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Scoring Systems ◽  
Disease Monitoring ◽  
Surrogate Markers ◽  
Invasive Monitoring ◽  
New Developments ◽  
Non Invasive ◽  
Inflammatory Bowel ◽  
New Biomarkers

Inflammatory bowel disease (IBD) is an umbrella term for Crohn’s disease (CD) and ulcerative colitis (UC). In light of evolving epidemiology of CD, its clinical management is still complex and remains a challenge for contemporary physicians. With the advent of new diagnostic and treatment paradigms, there is a growing need for new biomarkers to guide decision-making, differential diagnosis, disease activity monitoring, as well as prognosis. However, both clinical and endoscopic scoring systems, widely utilized for disease monitoring and prognosis, have drawbacks and limitations. In recent years, biochemical peptides have become available for IBD monitoring and more frequently used as surrogate markers of gut inflammation. Emerging concepts that revolve around molecular, stem cell, epigenetic, microbial or metabolomic pathways associated with vascular and epithelial gut barrier could lead to development of new CD biomarkers. Measurement of cell-derived microvesicles (MVs) in the blood of IBD patients is another emerging concept helpful in future disease management. In this review, we discuss novel concepts of non-invasive biomarkers, which may become useful in monitoring of CD activity and prognosis. We discuss metabolomics as a new powerful tool for clinicians to guide differential IBD diagnosis. In the coming years, new developments of prognostic tools are expected, aiming for breakthroughs in the management of patients with CD.

scholarly journals New Developments in Non-invasive Brain Stimulation in Chronic Pain

2020 ◽  
Vol 8 (3) ◽  
pp. 280-292
Author(s):  
Timothy J. Meeker ◽  
Rithvic Jupudi ◽  
Frederik A. Lenz ◽  
Joel D. Greenspan
Keyword(s):  
Chronic Pain ◽  
Brain Stimulation ◽  
New Developments ◽  
Non Invasive
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