“Diffuse Bronchiectasis of Genetic Origin”

Westernization and today’s changing life style is resulting in various health problems like Inflammatory Bowel diseases, which is a common entity encountered in surgical practise. Ulcerative colitis is the most common among them. Though it is believed to have auto immune and genetic origin, today’s life style, environment, diet and stress plays an important role in aetiology. The disease is prevalent in middle aged western and northern people characterised by abdominal pain with bloody diarrhoea, weight loss, anaemia and general debility. This condition has remissions and exacerbations. One should always keep in mind that inflammatory bowel diseases can have anorectal manifestations. Diagnosis is made on the basis of symptoms, stool exam. and endoscopy. Management is symptomatic i.e. antibiotics, anti-inflammatory, anti-spasmodic, multivitamins, immune suppression and if required admission, intravenous fluids. if no response colectomy. As such there is no satisfactory treatment till date, so it remains the difficult issue. Here we need to have an alternative, safe, convenient treatment. Ayurveda has an answer for such cases.

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Effects of genetic origin on phenotypic divergence in Brook Trout populations stocked with domestic fish

Ecosphere ◽

10.1002/ecs2.3119 ◽

2020 ◽

Vol 11 (5) ◽

Author(s):

Philippine Gossieaux ◽

Émilie Lavoie ◽

Pascal Sirois ◽

Isabel Thibault ◽

Louis Bernatchez ◽

...

Keyword(s):

Brook Trout ◽

Genetic Origin ◽

Phenotypic Divergence

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Recent progress understanding pathophysiology and genesis of brain AVM—a narrative review

Neurosurgical Review ◽

10.1007/s10143-021-01526-0 ◽

2021 ◽

Author(s):

Hans-Jakob Steiger

Keyword(s):

Large Degree ◽

Advanced Imaging ◽

Genetic Origin ◽

The Past ◽

Open Questions ◽

Brain Avm ◽

Pubmed Search ◽

Substantial Progress ◽

The Individual ◽

Arterial Aneurysms

AbstractConsiderable progress has been made over the past years to better understand the genetic nature and pathophysiology of brain AVM. For the actual review, a PubMed search was carried out regarding the embryology, inflammation, advanced imaging, and fluid dynamical modeling of brain AVM. Whole-genome sequencing clarified the genetic origin of sporadic and familial AVM to a large degree, although some open questions remain. Advanced MRI and DSA techniques allow for better segmentation of feeding arteries, nidus, and draining veins, as well as the deduction of hemodynamic parameters such as flow and pressure in the individual AVM compartments. Nonetheless, complete modeling of the intranidal flow structure by computed fluid dynamics (CFD) is not possible so far. Substantial progress has been made towards understanding the embryology of brain AVM. In contrast to arterial aneurysms, complete modeling of the intranidal flow and a thorough understanding of the mechanical properties of the AVM nidus are still lacking at the present time.

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Maternal genetic origin of the late and final Neolithic human populations from present‐day Poland

American Journal of Physical Anthropology ◽

10.1002/ajpa.24372 ◽

2021 ◽

Author(s):

Anna Juras ◽

Edvard Ehler ◽

Maciej Chyleński ◽

Łukasz Pospieszny ◽

Anna Elżbieta Spinek ◽

...

Keyword(s):

Human Populations ◽

Genetic Origin

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Pandemic of Childhood Myopia. Could New Indoor LED Lighting Be Part of the Solution?

Energies ◽

10.3390/en14133827 ◽

2021 ◽

Vol 14 (13) ◽

pp. 3827

Author(s):

David Baeza Moyano ◽

Roberto Alonso González-Lezcano

Keyword(s):

Technological Progress ◽

Visible Spectrum ◽

Visible Range ◽

Natural Light ◽

Genetic Origin ◽

Led Lighting ◽

Health Authorities ◽

The World ◽

Children’S Work ◽

Possible Cause

The existence of a growing myopia pandemic is an unquestionable fact for health authorities around the world. Different possible causes have been put forward over the years, such as a possible genetic origin, the current excess of children’s close-up work compared to previous stages in history, insufficient natural light, or a multifactorial cause. Scientists are looking for different possible solutions to alleviate it, such as a reduction of time or a greater distance for children’s work, the use of drugs, optometric correction methods, surgical procedures, and spending more time outdoors. There is a growing number of articles suggesting insufficient natural light as a possible cause of the increasing levels of childhood myopia around the globe. Technological progress in the world of lighting is making it possible to have more monochromatic LED emission peaks, and because of this, it is possible to create spectral distributions of visible light that increasingly resemble natural light in the visible range. The possibility of creating indoor luminaires that emit throughout the visible spectrum from purple to infrared can now be a reality that could offer a new avenue of research to fight this pandemic.

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Sudden Cardiac Death in Hereditary Dilated Cardiomyopathy

Sudden Cardiac Death ◽

10.5772/intechopen.91702 ◽

2020 ◽

Author(s):

Marianna Leopoulou ◽

Jo Ann LeQuang ◽

Joseph V. Pergolizzi ◽

Peter Magnusson

Keyword(s):

Sudden Cardiac Death ◽

Left Ventricle ◽

Sudden Death ◽

Risk Stratification ◽

Dilated Cardiomyopathy ◽

Cardiac Death ◽

Disease Risk ◽

Systolic Dysfunction ◽

Preventive Strategies ◽

Genetic Origin

Dilated cardiomyopathy (DCM) is characterized by the phenotype of a dilated left ventricle with systolic dysfunction. It is classified as hereditary when it is deemed of genetic origin; more than 50 genes are reported to be related to the condition. Symptoms include, among others, dyspnea, fatigue, arrhythmias, and syncope. Unfortunately, sudden cardiac death may be the first manifestation of the disease. Risk stratification regarding sudden death in hereditary DCM as well as preventive management poses a challenge due to the heterogeneity of the disease. The purpose of this chapter is to present the epidemiology, risk stratification, and preventive strategies of sudden cardiac death in hereditary DCM.

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Mammalian mitochondrial translation — revealing consequences of divergent evolution

Biochemical Society Transactions ◽

10.1042/bst20190265 ◽

2019 ◽

Vol 47 (5) ◽

pp. 1429-1436 ◽

Cited By ~ 2

Author(s):

Rawaa A. Z. Al-Faresi ◽

Robert. N. Lightowlers ◽

Zofia M. A. Chrzanowska-Lightowlers

Keyword(s):

Common Ancestor ◽

Current Knowledge ◽

Eukaryotic Cells ◽

Divergent Evolution ◽

Mitochondrial Translation ◽

Complete Understanding ◽

Genetic Origin ◽

Cryo Electron Microscopy ◽

Encoded Proteins ◽

Molecular Aspects

Abstract Mitochondria are ubiquitous organelles present in the cytoplasm of all nucleated eukaryotic cells. These organelles are described as arising from a common ancestor but a comparison of numerous aspects of mitochondria between different organisms provides remarkable examples of divergent evolution. In humans, these organelles are of dual genetic origin, comprising ∼1500 nuclear-encoded proteins and thirteen that are encoded by the mitochondrial genome. Of the various functions that these organelles perform, it is only oxidative phosphorylation, which provides ATP as a source of chemical energy, that is dependent on synthesis of these thirteen mitochondrially encoded proteins. A prerequisite for this process of translation are the mitoribosomes. The recent revolution in cryo-electron microscopy has generated high-resolution mitoribosome structures and has undoubtedly revealed some of the most distinctive molecular aspects of the mitoribosomes from different organisms. However, we still lack a complete understanding of the mechanistic aspects of this process and many of the factors involved in post-transcriptional gene expression in mitochondria. This review reflects on the current knowledge and illustrates some of the striking differences that have been identified between mitochondria from a range of organisms.

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