Goal-Based Safety Standards: Promises and Pitfalls

In conditions of exceeding the maximum permissible levels of power frequency electric field, the staff must use personal protective equipment. Requirements for such means are regulated by the system of occupational safety standards. The goal of this work is analyzed new requirements for power frequency and induced personal protective equipment in the regulatory interstate standards GOST 12.4.172 and GOST 12.4.283. The personal protective equipment new requirements for various types of work are substantiated to electrical personnel health safety during the maintenance and operation of power grid facilities. Increasing requirements for personal protective equipment improves the staff protection at ground potential and at wire potential, including in emergency situations such as induced and step voltage.

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TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C

JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik ◽

10.31942/jiffk.v15i2.2568 ◽

2018 ◽

Vol 15 (2) ◽

pp. 62

Author(s):

Risha Fillah Fithria ◽

Ririn Lispita Wulandari ◽

Devi Nisa Hidayati ◽

Lilis Rejeki

Keyword(s):

Single Dose ◽

Color Change ◽

Negative Control ◽

Control Group ◽

Hair Color ◽

Peanut Shell ◽

Control Group Design ◽

Safety Standards ◽

Arachis Hypogea ◽

Passive Behavior

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell

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Safety assessment of biological raw materials in the system of medicines quality assurance

10.33920/med-06-2002-05 ◽

2020 ◽

pp. 63-72

Author(s):

Yu. Olefir ◽

E. Sakanyan ◽

I. Osipova ◽

V. Dobrynin ◽

M. Smirnova ◽

...

Keyword(s):

Raw Materials ◽

State Level ◽

The State ◽

Spongiform Encephalopathy ◽

Safety Standards ◽

Wide Range ◽

The Russian Federation ◽

Key Aspects ◽

First Time ◽

Medicines Quality

The entry of a wide range of biotechnological products into the pharmaceutical market calls for rein-forcement of the quality, efficacy and safety standards at the state level. The following general monographs have been elaborated for the first time to be included into the State Pharmacopoeia of the Russian Federation, XIV edition: "Viral safety" and "Reduction of the risk of transmitting animal spongiform encephalopathy via medicinal products". These general monographs were elaborated taking into account the requirements of foreign pharmacopoeias and the WHO recommendations. The present paper summarises the key aspects of the monographs.

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