With the expanding use of wireless cellular networks, concerns have been communicated about the possible interaction of electromagnetic radiation with the human life, explicitly, the mind and brain. Mobile phones emanate radio frequency waves, a type of non-ionizing radiation, which can be absorbed by tissues nearest to where the telephone is kept. The effects on neuronal electrical activity, energy metabolism, genomic responses, neurotransmitter balance, blood–brain barrier permeability, mental psychological aptitude, sleep, and diverse cerebrum conditions including brain tumors are assessed. Health dangers may likewise develop from use of cellular communication, for instance, car accidents while utilizing the device while driving. These indirect well-being impacts surpass the immediate common troubles and should be looked into in more detail later on. In this chapter, we outline the possible biological impacts of EMF introduction on human brain.