Altered Vitamin D, Cyclic Nucleotide and Trace Mineral Metabolism in the X-Linked Hypophosphatemic Mouse

1980 ◽  
pp. 351-359 ◽  
Author(s):  
Ralph A. Meyer ◽  
Richard W. Gray ◽  
Gary M. Kiebzak ◽  
Paul M. Mish
Keyword(s):  
Vitamin D ◽  
Cyclic Nucleotide ◽  
Mineral Metabolism ◽  
Trace Mineral

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

Vitamin D Provision in High-Yield Dairy Cows During the Winter Housing Period

2014 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
L. Yuskiv ◽  
V. Vlizlo
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase Level ◽  
Mineral Metabolism ◽  
Physiological State ◽  
Blood Parameters ◽  
Postnatal Period ◽  
High Yield ◽  
Oral Supplementation ◽  
Calcium Phosphorus ◽  
Vitamin D 3

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.

scholarly journals Rare Case of Severe Hypocalcemia Due to PTH Resistance Related to Diet Pill

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A217-A218
Author(s):  
Rujuta Baban Katkar ◽  
Narasa Madam
Keyword(s):  
Vitamin D ◽  
Calcium Gluconate ◽  
Rare Case ◽  
Magnesium Deficiency ◽  
Mineral Metabolism ◽  
Urinary Calcium ◽  
Ionized Calcium ◽  
Diet Pill ◽  
Surgical History ◽  
Pth Resistance

Abstract Introduction: The production of parathyroid hormone (PTH) is essential for calcium the maintenance of normal mineral metabolism. Parathyroid cells have cell-surface calciumsensing receptors, even small changes in extracellular Ca induce rapid changes in PTH secretion. Hypocalcaemia is a well-recognized manifestation of magnesium deficiency. We present rare case of severe hypocalcemia due to PTH resistance caused by hypomagnesemia related to diet pill. Case Report: 61 year old Hispanic obese female with chronic gastritis on omeprazole 20 mg daily, no other significant past medical and surgical history, not taking any prescribed medications presents to ED with complaints of tingling and numbness around the mouth, abdominal cramps, chest pain, shortness of breath and anxiety. On arrival calcium was found to be 6.0mg/dl(8.2–10.2mg/dl) with ionized calcium of 0.60mmol/l(1.13-1.32mmol/l) and EGFR>90ml/min, Albumin-4.0g/l, Magnesium-1.1mg/dl(1.6–2.3mg/dl), Phosphorus-6.1mg/dl(2.4–4.5mg/dl),rest of the electrolytes were normal. Patient was given IV calcium gluconate 2g and magnesium which helped improving her symptoms. PTH was 1700pg/ml(23-73pg/ml), low Vitamin D 25-hydroxy 20ng/dl(30-100ng/dl). Urinary calcium was <1mg/dl(2.0–17.5mg/dl). Vitamin D1,25- dihydroxy 34pg/ml(18-78pg/ml), PTH-like peptide levels 0.6pmol/l(<4.2pmol/l). EKG was normal no QT interval changes. For 4 weekspatient was taking weight loss medication was given to her by her brother called nucific-bio-x4. Patient had lost 4 pounds while taking the medication and had suppression of appetite. Physical features of pseudohypoparathyroidism were not seen. Patient had poor dietary intake of calcium, denied taking vitamin D supplements. Patient was given calcium acetate 2001 mg TID with meals, calcitriol 0.5mcg daily and calcium gluconate 2g IV intermittently was given. That improved her calcium levels to 6.8mg/dl with ionized calcium-0.90mmol/l. Magnesium was replaced IV and discharged on magnesium oxide 400mg BID to maintain magnesium the normal range. The patient was given loading dose of ergocalciferol 50,000 IUfor 8 weeks. At the time of discharge repeat PTH levels were 1600 pg/ml and calcium levels were 8.2mg/dl. 3D CT of the neck did not parathyroid mass. After discharge patient continued on oral calcium and magnesium to maintain calcium levels between 8.4–10.2mg/dl. After discharge calcium levels were 8.6mg/dl, vitamin D 25-hydroxy levels were 32ng/dl and maintenance dose of vitamin D3 2000 IU daily also continued. Nucific-bio-x4 pill was discontinued. Conclusion: In conclusion, severe life threatening hypocalcemia can occur with unsupervised weight lossmedications due to malabsorption of magnesium in patient with likely mutation in magnesium receptors causing PTH resistance. Vitamin D deficiency worsens hypocalcemia resulting into secondary hyperparathyroidism.

Vitamin D and atopic dermatitis

2021 ◽  
pp. 26-36
Author(s):  
Mariya Aleksandrovna Bochkareva ◽  
Svetlana Viktorovna Bulgakova ◽  
Anula Viktorovna Melikova
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Mineral Metabolism ◽  
Active Form ◽  
Allergic Diseases ◽  
The Body ◽  
Biological Processes ◽  
Skeletal System ◽  
Rapid Spread ◽  
Global Health Problem

Allergic diseases, in particular, atopic dermatitis, are becoming a global health problem due to the rapid spread, both as an independent disease and as a predictor of the development of bronchial asthma. Discovery of all the processes of the pathogenesis of atopic dermatitis will provide great opportunities for the prevention and treatment of this disease. In this regard, special attention is paid to vitamin D, which becomes more and more popular all over the world every year. In addition to the known and studied consequences of vitamin D deficiency for skeletal system health and mineral metabolism, recent studies have shown that calcitriol, the active form of vitamin D, is involved in many biological processes in the body, including the regulation of the immune system. The discovery of the vitamin D receptor on various cells of the body opens up new prospects for studying the course of various diseases, such as diabetes mellitus, vascular atherosclerosis, obesity, autoimmune diseases, oncology and allergies. The review will be devoted to this problem. 38 foreign and 2 domestic sources are cited.

Serum 25-hydroxyvitamin D and vitamin D-binding protein levels and mineral metabolism after partial and total gastrectomy

1980 ◽  
Vol 79 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Michio Imawari ◽  
Kunihisa Kozawa ◽  
Yasuo Akanuma ◽  
Sumihiko Koizumi ◽  
Hiroshige Itakura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Total Gastrectomy ◽  
Mineral Metabolism ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
Protein Levels ◽  
25 Hydroxyvitamin D

Vitamin D and mineral metabolism in the very low birth weight infant receiving 400 IU of vitamin D

1990 ◽  
Vol 116 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Richard Cooke ◽  
Bruce Hollis ◽  
Cynthia Conner ◽  
Donna Watson ◽  
Susan Werkman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Mineral Metabolism ◽  
Low Birth Weight Infant

scholarly journals The Vitamin D Analog ED-71 Is a Potent Regulator of Intestinal Phosphate Absorption and NaPi-IIb

Endocrinology ◽  
2012 ◽  
Vol 153 (11) ◽  
pp. 5150-5156 ◽  
Author(s):  
Alex J. Brown ◽  
Fanjie Zhang ◽  
Cynthia S. Ritter
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Mineral Metabolism ◽  
Oral Treatment ◽  
Fold Increase ◽  
Alveolar Type ◽  
Mrna Levels ◽  
Potent Inducer ◽  
Vitamin D Analog ◽  
Fold Induction

Abstract The vitamin D analog ED-71 [1α,25-dihydroxy-2β-(3-hydroxypropyloxy)vitamin D3] has been approved for treatment of osteoporosis in Japan, but its effects on mineral metabolism have not been fully explored. We investigated the actions of ED-71 on phosphate (Pi) absorption and induction of the intestinal sodium/phosphate cotransporters. Oral treatment of vitamin D-deficient rats with ED-71 (20 pmol every other day for 8 d) produced a maximal 8-fold increase in duodenal Pi absorption, measured by the in situ loop method, whereas 1,25-dihyroxyvitamin D3 [1,25(OH)2D3], at doses up to 150 pmol, had no effect. This action of ED-71 was attributable to a dramatic 24-fold induction of sodium-dependent Pi transporter type IIb (NaPi-IIb) mRNA in the duodenum; Pit-1 and Pit-2 mRNA levels were not increased. In vitamin D-replete rats, ED-71 treatment (50 pmol) at 72 and 24 h before death increased NaPi-IIb mRNA in the duodenum and jejunum, but not the ileum, whereas 1,25(OH)2D3 at 1000 pmol was ineffective in all segments. Single oral doses of ED-71 increased mouse intestinal NaPi-IIb mRNA and protein between 6 and 24 h. Surprisingly, rat lung NaPi-IIb was not increased by ED-71, despite its coexpression with the vitamin D receptor in alveolar type II cells. However, ED-71 did not induce intestinal NaPi-IIb in vitamin D receptor-ablated mice. The greater potency of ED-71 than 1,25(OH)2D3 on NaPi-IIb appears to be due to much higher and more prolonged levels of ED-71 in the circulation. In summary, ED-71, due to its disparate pharmacokinetics, is a much more potent inducer of intestinal Pi absorption and NaPi-IIb than 1,25(OH)2D3, suggesting a role for this analog in the treatment of Pi-wasting disorders.

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