Fatty Acid Regulation of Breast Cancer Cell Growth and Invasion

1997 ◽  
pp. 47-55 ◽  
Author(s):  
David P. Rose ◽  
Jeanne M. Connolly ◽  
Xin-Hua Liu
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

2020 ◽  
Vol 21 (13) ◽  
pp. 4652 ◽  
Author(s):  
Chia-Chien Hsieh ◽  
Huai-Hsuan Chiu ◽  
Chih-Hsuan Wang ◽  
Ching-Hua Kuo
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Fatty Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
Breast Cancer Cell Growth ◽  
And Migration

Breast cancer is the most common cancer among women. Adiposity generally accompanies immune cell infiltration and cytokine secretion, which is ideal for tumor development. Aspirin is a chemopreventive agent against several types of cancer. The aim of this study was to investigate whether aspirin inhibits the growth of 4T1 breast cancer cells by inhibiting the inflammatory response and regulating the metabolomic profile of 3T3-L1 adipocytes. 3T3-L1 adipocyte-conditioned medium (Ad-CM) was used to mimic the obese adipose tissue microenvironment in 4T1 cells. The results revealed that aspirin inhibited macrophage chemoattractant protein (MCP-1), interleukin (IL-6), IL-1β, and plasminogen activator inhibitor (PAI-1) production in 3T3-L1 adipocytes stimulated by tumor necrosis factor-alpha (TNF-α) and lipopolysaccharide (LPS). In the obesity-associated model, Ad-CM significantly promoted 4T1 cell growth and migration, which were attenuated after aspirin treatment. The results of metabolic analyses using Ad-CM showed that amino acid metabolites and oxidative stress were increased in mature 3T3-L1 adipocytes compared to those in fibroblasts. Aspirin treatment modified metabolites involved in suppressing lipogenesis, oxidative stress, and neoplastic formation. In the relative fatty acid quantitation analysis of Ad-CM, aspirin diminished fatty acid contents of C16:1, C18:1, C18:2, C20:4, and C24:1. This study is the first to show that aspirin modifies the metabolomics and fatty acid composition of 3T3-L1 adipocytes and inhibits obesity-associated inflammation that contributes to obesity-related breast cancer cell growth and migration.

scholarly journals The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis

2021 ◽  
pp. 2004635
Author(s):  
Hai‐feng Shen ◽  
Wen‐juan Zhang ◽  
Ying Huang ◽  
Yao‐hui He ◽  
Guo‐sheng Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Transcriptional Activation ◽  
Dual Function ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages

2008 ◽  
Vol 180 (5) ◽  
pp. 3158-3165 ◽  
Author(s):  
Dongqing Li ◽  
Yanmei Li ◽  
Xianglei Wu ◽  
Qiao Li ◽  
Jing Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cd4 T Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis

2011 ◽  
Vol 52 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Jixia Li ◽  
Feng Zhu ◽  
Ronald A. Lubet ◽  
Antonella De Luca ◽  
Clinton Grubbs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Methyl Ether ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Resistant Breast Cancer Cell

scholarly journals Differential Roles of Fibroblast Growth Factor Receptors (FGFR) 1, 2 and 3 in the Regulation of S115 Breast Cancer Cell Growth

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49970 ◽  
Author(s):  
Kati M. Tarkkonen ◽  
Emeli M. Nilsson ◽  
Tiina E. Kähkönen ◽  
Julien H. Dey ◽  
Jari E. Heikkilä ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Fibroblast Growth Factor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth

1999 ◽  
Vol 72 (4) ◽  
pp. 230-239 ◽  
Author(s):  
Rosemary B. Duda ◽  
Ying Zhong ◽  
Vinicio Navas ◽  
Michael Z. C. Li ◽  
Brian R. Toy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
American Ginseng ◽  
Therapeutic Agents ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mcf 7

scholarly journals Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis

2018 ◽  
Vol 38 (11) ◽  
pp. 6217-6223
Author(s):  
HAIHONG SHI ◽  
JIN LIU ◽  
YIFAN TU ◽  
CARL E. FRETER ◽  
CHUNFA HUANG
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Oolong Tea ◽  
Tea Extract
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