Intrauterine Insemination in Unexplained Female Infertility

Reproductive technologies, female infertility, and the risk of imprinting-related disorders

Clinical Epigenetics ◽

10.1186/s13148-020-00986-3 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Patricia Fauque ◽

Jacques De Mouzon ◽

Aviva Devaux ◽

Sylvie Epelboin ◽

Marie-José Gervoise-Boyer ◽

...

Keyword(s):

Molecular Mechanisms ◽

Assisted Reproductive Technologies ◽

Intrauterine Insemination ◽

Reproductive Technologies ◽

Female Infertility ◽

Global Risk ◽

Vitro Fertilization ◽

Increased Risk ◽

Genomic Imprints

Abstract Background Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints. However, little is currently known about the risk of imprinting defects according to the type of ART or the type of underlying female infertility. From the French national health database, a cohort of 3,501,495 singletons born over a 5-year period (2013–2017) following fresh embryo or frozen embryo transfers (fresh-ET or FET from in vitro fertilization), intrauterine insemination, or natural conception was followed up to early childhood. Based on clinical features, several syndromes/diseases involving imprinted genes were monitored. The effects of ART conception and the underlying cause of female infertility were assessed. Results Compared with infants conceived naturally, children born after fresh-ET had a higher prevalence of imprinting-related diseases, with an aOR of 1.43 [95% CI 1.13–1.81, p = 0.003]. Namely, we observed an increased risk of neonatal diabetes mellitus (1.96 aOR [95% CI 1.43–2.70], p < 0.001). There was an overall independent increase in risk of imprinting diseases for children with mothers diagnosed with endometriosis (1.38 aOR [95% CI 1.06–1.80], p = 0.02). Young and advanced maternal age, primiparity, obesity, smoking, and history of high blood pressure or diabetes were also associated with high global risk. Conclusions This prospective epidemiological study showed that the risk of clinically diagnosed imprinting-related diseases is increased in children conceived after fresh embryo transfers or from mothers with endometriosis. The increased perturbations in genomic imprinting could be caused by controlled ovarian hyperstimulation and potentially endometriosis through the impairment of endometrial receptivity and placentation, leading to epigenetic feto-placental changes. Further studies are now needed to improve understanding of the underlying molecular mechanisms (i.e. genetic or epigenetic causes).

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Female Factors related with Infertility and Their Pregnancy Outcome after Intrauterine Insemination: Experience of 790 Cases in Bangladesh

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v6i2.42977 ◽

2019 ◽

Vol 6 (2) ◽

pp. 87-91

Author(s):

Shafeya Khanam ◽

Rehana Khanam ◽

Muqsuda Ashraf Shuvro ◽

Morium Faruque Shati ◽

Trifa Obayed

Keyword(s):

Pregnancy Outcome ◽

Intrauterine Insemination ◽

Female Infertility ◽

Infertile Women ◽

Study Population ◽

The Mean ◽

Infertile Couples ◽

One Year ◽

Natural Cycles

Background: Several female factors are related with the cause of infertility. Objectives: The purpose of the present study was to assess female factors related with infertility and their pregnancy outcome after intrauterine insemination. Methodology: This prospective cohort study was carried out at a private infertility centre (Central Hospital Limited, Dhaka) in Dhaka city of Bangladesh from January 2012 to December 2017 for a period of 6 years. Infertile couples who already had undergone natural cycles of super-ovulation for six months or whose duration of infertility was more than one year were included. Infertile women were evaluated and the causes of infertility were assessed. The follow up was performed to see the pregnancy outcome. Result: A total number of 790 women were recruited. The mean age with standard deviation of study population was 28.94±5.386 years. Among 790 infertile women 12 women were become pregnant after IUI. Among these 12 women female factors of infertility was present in 8(66.7%) cases and the rest 4(33.3%) cases were absent. However, 778 women could not pregnant after IUI and among these 277(35.6%) cases had the presence of female factors and the rest 501(64.4%) cases had absence of female infertility causes. The presence of female factor had 3.62 (95% CI 1.08-12.12) times more risk to become pregnant among the infertile women after IUI (p=0.026). Among 790 infertile women 285(36.1%) women had presence of female infertility factors. Conclusion: In conclusion female factors are significantly related with infertility and their pregnancy outcome after intrauterine insemination. Journal of Current and Advance Medical Research 2019;6(2):87-91

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1630: Sufficient Total Motile Sperm for Intrauterine Insemination is Easily Obtained by Assisted Ejaculation of Men with Spinal Cord Injury

The Journal of Urology ◽

10.1016/s0022-5347(18)33822-9 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 525-525

Author(s):

Charles M. Lynne ◽

Nancy L. Brackett ◽

Teodoro C. Aballa ◽

Emad Ibrahim ◽

Apostolos Kafetsoulis

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Intrauterine Insemination ◽

Motile Sperm ◽

Cord Injury ◽

Assisted Ejaculation

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Study on Causes of Female Infertility at National Ayurveda Teaching Hospital, Borella, Sri Lanka: A Survey Based Study

Research in Pharmacy and Health Sciences ◽

10.32463/rphs.2017.v03i01.02 ◽

2017 ◽

Vol 3 (1) ◽

pp. 249-252

Author(s):

Farzana MUZN ◽

Arshiya Sultana

Keyword(s):

Sri Lanka ◽

Teaching Hospital ◽

Married Women ◽

Female Infertility ◽

Policy Makers ◽

Complex Disorder ◽

Anovulatory Cycle ◽

Common Causes ◽

Increasing Trend ◽

One Year

Background: Infertility is defined as the inability to conceive after at least one year of unprotected intercourse. It is a complex disorder with significant medical, psychosocial, and economic problems. In about one third of couples are infertile. Approximately 167 million married women aged 15-49 years in developing countries were infertility. The present study aimed to determine the most common causes of female infertility in patients who visiting the National Ayuvedic Teaching Hospital, Borella, Sri Lanka. Methods: In this study 635 infertile (primary and secondary) women were selected to determine the causes of infertility. The subjects were selected from the gynecology clinic, between the periods of February 2015 to March 2016. The data were gathered using a questionnaire; and after that proper statistical method was applied to analyze the data. Results: From the results age between 28-37 years (37.16%) are more prevalent to infertility and the causes of infertility are mainly due to anovulatory cycle (31.18%) and menstrual irregularities (19.21%). BMI also one of the significant cause for infertility. Conclusion: Therefore, identifying the risk factors and proper treatment on time along with policy makers providing facilities to resolve the infertility could possible diverse this alarming increasing trend of infertility.

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EVALUATION OF HYSTEROSALPINGOGRAPHY VERSUS LAPAROSCOPY IN THE DETERMINATION OF TUBAL FACTORS IN FEMALE INFERTILITY: A HOSPITAL BASED COMPARATIVE STUDY.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i9.1421 ◽

2020 ◽

Vol 4 (9) ◽

Author(s):

Richa Choudhary ◽

Rishikant Sinha

Keyword(s):

Female Infertility ◽

Diagnostic Methods ◽

Panoramic View ◽

Tubal Patency ◽

Pelvic Organs ◽

Clinical Investigations ◽

Detailed Assessment ◽

Reproductive Anatomy ◽

Tubal Pathology

Objectives: Hysterosalpingography and laparoscopy both are the diagnostic methods for assessment of female infertility. The present study was to compare the evaluation of hysterosalpingography (HSG) versus laparoscopy in determination of tubal factors in female infertility. Methods: Detailed assessment, physical examination and clinical investigations were performed in all 100 infertile female with age 20 years to 40 years. All patients were advised to perform digital HSG. Patients with an abnormal HSG underwent laparoscopy without delay, whereas in patients with a normal HSG, laparoscopy was performed three months after HSG. HSG is best scheduled during the 2nd -5th day interval immediately following the end of menstruation, to minimize risk for infection, avoid interference from intrauterine blood and clot, and to prevent any possibility that the procedure might be performed after conception. Results: Data was analysed by using IBM SPSS version 23 software. All data was tabulated and percentages were calculated. Mean ± standard deviation was observed. Conclusions: Diagnostic laparoscopy is the gold standard in diagnosing tubal pathology and other intra-abdominal causes of infertility. Other hand, Hysterosalpingography is a frequently utilized diagnostic tool in the assessment of tubal status and detection of uterine anatomical defects in infertility. Hysterosalpingography and laparoscopy are not alternatives but complimentary investigations. But, inadequacy of hysterosalpingography (HSG) in determining the state of tubal patency, emphasizes the need for laparoscopy. Laparoscopy provides both a panoramic view of the pelvic reproductive anatomy and a magnified view of pelvic organs and peritoneal surfaces. Keywords: Female infertility, Tubal patency, HSG, Laparoscopy

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