scholarly journals Application of ProteinChip Array Profiling in Serum Biomarker Discovery for Patients Suffering From Severe Acute Respiratory Syndrome

2007 ◽  
pp. 313-331 ◽  
Author(s):  
Timothy T. C. Yip ◽  
William C. S. Cho ◽  
Wai Wai Cheng ◽  
Johnny W. M. Chan ◽  
Victor W. S. Ma ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Biomarker Discovery ◽  
Serum Biomarker ◽  
Proteinchip Array

Analysis of mass spectrometry data for serum biomarker discovery

2007 ◽  
Author(s):  
Habtom W. Ressom ◽  
Rency S Varghese ◽  
Lenka Goldman ◽  
Christopher A. Loffredo ◽  
Mohamed Abdel-Hamid ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Biomarker Discovery ◽  
Mass Spectrometry Data ◽  
Serum Biomarker

scholarly journals Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

2008 ◽  
Vol 2 (9) ◽  
pp. 1223-1233 ◽  
Author(s):  
Earle F. Burgess ◽  
Amy-Joan L. Ham ◽  
David L. Tabb ◽  
Dean Billheimer ◽  
Bruce J. Roth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proteomic Analysis ◽  
Biomarker Discovery ◽  
Protein Complexes ◽  
Serum Biomarker

1411: Serum Biomarker Discovery using Proteomics Approaches to Predict Prostate Cancer Recurrence

2005 ◽  
Vol 173 (4S) ◽  
pp. 383-383
Author(s):  
C. Nicole White ◽  
Zhen Zhang ◽  
Derek Chappell ◽  
Jason M. Rosenzweig ◽  
Lori J. Sokoll ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Biomarker Discovery ◽  
Cancer Recurrence ◽  
Serum Biomarker ◽  
Prostate Cancer Recurrence

Serum biomarker discovery for ovarian serous carcinoma using novel proteomic methods

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 16058-16058 ◽  
Author(s):  
J. A. Borgia ◽  
C. Frankenberger ◽  
K. Kaiser ◽  
S. E. McCormack ◽  
L. Usha ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Biomarker Discovery ◽  
Tumor Resection ◽  
Stage I ◽  
Serum Biomarker ◽  
Serous Carcinoma ◽  
Major Surgery ◽  
Ovarian Serous Carcinoma ◽  
Baseline Subtraction ◽  
Operative Specimen

16058 Background: Ovarian serous carcinoma (OSC) is the most common ovarian cancer sub-type and fourth leading cause of cancer-related deaths for women in the US. Unfortunately, more than two-thirds of women with ovarian cancer present at an advanced stage, when prognosis is poor. Developing methods to detect ovarian cancer at stage I, when it is 90% curable by surgery, or at stage II where survival is 70%, offers the best prospect for changing the clinical course of this dread malignancy. Methods: Serum specimens were collected both before and 3–6 weeks after tumor resection for patients with Stage I/ II high-grade serous carcinoma. None suffered recurrence within 6 months. We collected 98 ‘paired’ (pre- and post operative) serum specimens; including 41 benign paired specimens for comparison. A SELDI-TOF mass spectrometer was used to generate the serum proteomic profiles, optimized for the 2,000–40,000 m/z range. All data analyses were performed in a blinded manner using Bioconductor, an extension of the R-project statistical platform (v2.2.0). Raw spectra were processed as follows: baseline subtraction, spectra normalization, and differential peak detection. Aligned peaks were sorted into groups, based on tumor pathology and pre- vs. post-operative specimen type, and compared using a two tailed homoscedastic t-test. Results: The proteomes of pre- and post-operative serum from 10 patients with OSC were evaluated for significant changes in composition and compared with a set of 8 ‘normal’ specimens (i.e. patients undergoing major surgery for benign disease). We identified 18 serum components common to all OSC pre-op specimens that were extensively reduced or absent (p < 0.05) after tumor resection and 26 components capable of discerning pre-op OSC from pre-op normal specimens (p < 0.05). Most notable of these are components with m/z ratios of 2029.1, 2203.6, 6442.3, and 6851.9, based on level of significance (p < 0.001). Conclusions: These results validate the power of our ‘pre- vs. post- operative’ analysis strategy for the identification of novel serum biomarker candidates. Efforts are currently focused on expanding the scope of our specimen bank and identifying the putative biomarker candidates via mass spectrometry. No significant financial relationships to disclose.

scholarly journals P-226 Pharmacodynamic Serum Biomarker Discovery in Pediatric Inflammatory Bowel Diseases

2016 ◽  
Vol 22 ◽  
pp. S77-S78
Author(s):  
Christopher Heier ◽  
Yetrib Hathout ◽  
Alyson Fiorillo ◽  
Eric Hoffman ◽  
Heather Gordish-Dressman ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Biomarker Discovery ◽  
Serum Biomarker ◽  
Bowel Diseases ◽  
Inflammatory Bowel

M1111 A Label-Free Proteomics Approach to Serum Biomarker Discovery for Crohn's Disease

2009 ◽  
Vol 136 (5) ◽  
pp. A-352
Author(s):  
Paolo Nanni ◽  
Giulia Roda ◽  
Laura Mezzanotte ◽  
Alessandra Caponi ◽  
Fredrik Levander ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Biomarker Discovery ◽  
Serum Biomarker ◽  
Label Free ◽  
Proteomics Approach

scholarly journals In-depth proteomic analysis of tissue interstitial fluid for hepatocellular carcinoma serum biomarker discovery

2017 ◽  
Vol 117 (11) ◽  
pp. 1676-1684 ◽  
Author(s):  
Jian Zhang ◽  
Ning Hao ◽  
Wei Liu ◽  
Min Lu ◽  
Longqin Sun ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proteomic Analysis ◽  
Interstitial Fluid ◽  
Biomarker Discovery ◽  
Serum Biomarker ◽  
Tissue Interstitial Fluid

Analytical Considerations for Mass Spectrometry Profiling in Serum Biomarker Discovery

2009 ◽  
Vol 29 (1) ◽  
pp. 57-69 ◽  
Author(s):  
Gordon R. Whiteley ◽  
Simona Colantonio ◽  
Andrea Sacconi ◽  
Richard G. Saul
Keyword(s):  
Mass Spectrometry ◽  
Biomarker Discovery ◽  
Serum Biomarker

scholarly journals Lung Cancer Serum Biomarker Discovery Using Glycoprotein Capture and Liquid Chromatography Mass Spectrometry

2010 ◽  
Vol 9 (12) ◽  
pp. 6440-6449 ◽  
Author(s):  
Xuemei Zeng ◽  
Brian L. Hood ◽  
Mai Sun ◽  
Thomas P. Conrads ◽  
Roger S. Day ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lung Cancer ◽  
Liquid Chromatography ◽  
Biomarker Discovery ◽  
Serum Biomarker ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry
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