scholarly journals Continuous Evaluation of Large-Scale Information Access Systems: A Case for Living Labs

2019 ◽  
pp. 511-543 ◽  
Author(s):  
Frank Hopfgartner ◽  
Krisztian Balog ◽  
Andreas Lommatzsch ◽  
Liadh Kelly ◽  
Benjamin Kille ◽  
...  
Keyword(s):  
Large Scale ◽  
Information Access ◽  
Continuous Evaluation ◽  
Living Labs

Digital Biomarkers for supporting transitional care decisions: Protocol for a transnational feasibility study (Preprint)

2021 ◽  
Author(s):  
Despoina Petsani ◽  
Sara Ahmed ◽  
Vasileia Petronikolou ◽  
Eva Kehayia ◽  
Mika Alastalo ◽  
...  
Keyword(s):  
Data Collection ◽  
Large Scale ◽  
Transitional Care ◽  
Care Process ◽  
Local Context ◽  
Pilot Phase ◽  
Living Lab ◽  
Patient Reported ◽  
Living Labs ◽  
Digital Biomarkers

BACKGROUND VITALISE is a H2020 project that aims to harmonize Living Lab procedures and facilitate the access to European Health and Wellbeing research infrastructures. In this context, this study presents a joint research activity (JRA) that will be conducted within VITALISE, in transitional care domain, in order to test and validate the harmonized Living Lab procedures and infrastructures. The collection of data from various sources (ICT, clinical and patient reported outcome measures) demonstrated capacity to assess risk and support decision during care transitions but there is no harmonized way of combining this information. OBJECTIVE This study primarily aims to evaluate the feasibility and benefit of collecting multichannel data across Living Labs on the topic of transitional care and to harmonize the data processes and collection. Secondly, we aim to investigate the collection and use of digital biomarkers and explore initial patterns in the data that demonstrate the potential to predict transition outcomes such as readmissions and adverse events. METHODS The current research protocol presents a multi-center, prospective, observational cohort study that will consist of three phases, running consecutively in multiple sites: a co-creation phase, a testing and simulation phase and a transnational pilot phase. The co-creation phase aims to build a common understanding among different sites, investigate the differences of hospitalization discharge management among countries and the willingness of different stakeholders to use technological solutions in the transitional care process. The testing and simulation phase aims to explore ways of integrating observation of a patient’s clinical condition, patient involvement and discharge education in transitional care. The objective of the simulation phase is to evaluate the feasibility and the barriers that are faced by a healthcare professional in assessing transition readiness. The transnational pilot phase takes input from co-creation and testing and stimulation phase. The aim is to pilot the already designed activities from previous phases and collect data to conduct a first predictive analysis. RESULTS The co-creation phase will be completed by April 2022. The testing and simulation phase will begin in September 2022 and will partially overlap with the deployment of the transnational pilot phase that will start the same month. The data collection of the transnational pilots will be finalized by the end of June 2023. Data processing is expected to be completed by March 2024. The results will consist of guidelines and implementation pathway for large scale study and the analysis for identifying initial patterns in the acquired data. CONCLUSIONS The knowledge acquired though this research will lead to harmonized procedures and data collection for Living Labs that support transitions in care. In addition, this research contributes to the increase in capacity to perform Big Data analytics while accounting for each local context and across Living Labs.

Charting a Course in the 90’s: From Field Measurement to Management Information Systems

1996 ◽  
Author(s):  
Greg J. Chudiak ◽  
Mike Yoon
Keyword(s):  
Information Technology ◽  
Information Systems ◽  
Control Systems ◽  
Large Scale ◽  
Information Access ◽  
Leading Edge ◽  
Business Environment ◽  
Small Scale ◽  
Application Architecture ◽  
Business Requirements

What’s new in the pipeline industry in terms of field automation and information systems technology? What impact are these technologies having on the business environment and how will they affect the way we do business in the future? How can we leverage these technologies to support the demanding business requirements of today and tomorrow? The paper takes a quick look back at the origin of the first field control systems and office automation. Through a chronological progression we arrive at what’s on the leading edge of information technology today. Based upon current architectures we identify how systems are implemented and some of the issues affecting the integration of field and office information systems. From small scale compressor control systems to large scale pipeline information systems we look at the informational requirements and how systems currently implement the required functionality. Within the business environment we examine the need for corporate-wide information access. Considering both operational and business/economic levels, we identify some of the key informational requirements for the effective operation and management of a pipeline. Based upon a corporate-wide information access model and current business and technology trends, we present an enterprise application architecture that would meet the operational and business requirements of a pipeline company. Finally, the paper takes at look at some of the business and management issues associated with implementing new information technology. It offers some basic guidelines on helping managers reduce the risks and ultimately deliver successful projects for their company.

scholarly journals The BSGatlas: An enhanced annotation of genes and transcripts for the Bacillus subtilis genome with improved information access

2019 ◽  
Author(s):  
Adrian Sven Geissler ◽  
Christian Anthon ◽  
Enrique González-Tortuero ◽  
Line Dahl Poulsen ◽  
Thomas Beuchert Kallehauge ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
High Throughput ◽  
Large Scale ◽  
Information Access ◽  
Fold Increase ◽  
Genomic Region ◽  
Transcription Start Sites ◽  
Genomic Knowledge ◽  
The Individual ◽  
Transcript Map

AbstractThe genome of Bacillus subtilis continues to provide exiting genomic insights. However, the growing collective genomic knowledge about this micro-organism is spread across multiple annotation resources. Thus, the full annotation is not directly accessible neither for specific genes nor for large-scale high-throughput analyses. Furthermore, access to annotation of non-coding RNA genes (ncRNAs) and polycistronic mRNAs is difficult. To address these challenges we introduce the Bacillus subtilis genome atlas, BSGatlas, in which we integrate and unify multiple existing annotation resources. Our integration provides twice as many ncRNAs than the individual resources, improves the positional annotation for 70% of the combined ncRNAs, and makes it possible to infer specific ncRNA types. Moreover, we unify known transcription start sites, termination, and transcriptional units (TUs) as a comprehensive transcript map. This transcript map implies 815 new TUs and 6, 164 untranslated regions (UTRs), which is a five-fold increase over existing resources. We furthermore, find 2, 309 operons covering the transcriptional annotation for 93% of all genes, corresponding to an improvement by 11%. The BSGatlas is available in multiple formats. A user can either download the entire annotation in the standardized GFF3 format, which is compatible with most bioinformatics tools for omics and high-throughput studies, or view the annotation in an online browser at http://rth.dk/resources/bsgatlas.ImportanceThe Bacillus subtilis genome has been studied in numerous context and consequently multiple efforts have been made in providing a complete annotation. Unfortunately, a number of resources are no longer maintained, and (i) the collective annotation knowledge is dispersed over multiple resources, of which each has a different focus of what type of annotation information they provide. (ii) Thus, it is difficult to easily and at a large scale obtain information for a genomic region or genes of interest. (iii) Furthermore, all resources are essentially incomplete when it comes to annotating non-coding and structured RNA, and transcripts in general. Here, we address all three problems by first collecting existing annotations of genes and transcripts start and termination sites; afterwards resolving discrepancies in annotations and combining them, which doubled the number of ncRNAs; inferring full transcripts and 2,309 operons from the combined knowledge of known transcript boundaries and meta-information; and critically providing it all in a standardized UCSC browser. That interface and its powerful set of functionalities allow users to access all the information in a single resource as well as enables them to include own data on top the full annotation.

scholarly journals BSGatlas: a unified Bacillus subtilis genome and transcriptome annotation atlas with enhanced information access

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Adrian Sven Geissler ◽  
Christian Anthon ◽  
Ferhat Alkan ◽  
Enrique González-Tortuero ◽  
Line Dahl Poulsen ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Type Species ◽  
Large Scale ◽  
Information Access ◽  
Model Systems ◽  
Transcription Start ◽  
Content Type ◽  
Link Type ◽  
Genome Wide ◽  
Transcript Map

A large part of our current understanding of gene regulation in Gram-positive bacteria is based on Bacillus subtilis , as it is one of the most well studied bacterial model systems. The rapid growth in data concerning its molecular and genomic biology is distributed across multiple annotation resources. Consequently, the interpretation of data from further B. subtilis experiments becomes increasingly challenging in both low- and large-scale analyses. Additionally, B. subtilis annotation of structured RNA and non-coding RNA (ncRNA), as well as the operon structure, is still lagging behind the annotation of the coding sequences. To address these challenges, we created the B. subtilis genome atlas, BSGatlas, which integrates and unifies multiple existing annotation resources. Compared to any of the individual resources, the BSGatlas contains twice as many ncRNAs, while improving the positional annotation for 70 % of the ncRNAs. Furthermore, we combined known transcription start and termination sites with lists of known co-transcribed gene sets to create a comprehensive transcript map. The combination with transcription start/termination site annotations resulted in 717 new sets of co-transcribed genes and 5335 untranslated regions (UTRs). In comparison to existing resources, the number of 5′ and 3′ UTRs increased nearly fivefold, and the number of internal UTRs doubled. The transcript map is organized in 2266 operons, which provides transcriptional annotation for 92 % of all genes in the genome compared to the at most 82 % by previous resources. We predicted an off-target-aware genome-wide library of CRISPR–Cas9 guide RNAs, which we also linked to polycistronic operons. We provide the BSGatlas in multiple forms: as a website (https://rth.dk/resources/bsgatlas/), an annotation hub for display in the UCSC genome browser, supplementary tables and standardized GFF3 format, which can be used in large scale -omics studies. By complementing existing resources, the BSGatlas supports analyses of the B. subtilis genome and its molecular biology with respect to not only non-coding genes but also genome-wide transcriptional relationships of all genes.

Library and information services: impact on patient care quality

2014 ◽  
Vol 27 (8) ◽  
pp. 672-683 ◽  
Author(s):  
Joanne Gard Marshall ◽  
Jennifer Craft Morgan ◽  
Cheryl A. Thompson ◽  
Amber L. Wells
Keyword(s):  
Patient Care ◽  
Critical Incident ◽  
Large Scale ◽  
Positive Impact ◽  
Information Access ◽  
Care Quality ◽  
Access Methods ◽  
Content Type ◽  
Library Resources ◽  
Patient Care Quality

Purpose – The purpose of this paper is to explore library and information service impact on patient care quality. Design/methodology/approach – A large-scale critical incident survey of physicians and residents at 56 library sites serving 118 hospitals in the USA and Canada. Respondents were asked to base their answers on a recent incident in which they had used library resources to search for information related to a specific clinical case. Findings – Of 4,520 respondents, 75 percent said that they definitely or probably handled patient care differently using information obtained through the library. In a multivariate analysis, three summary clinical outcome measures were used as value and impact indicators: first, time saved; second, patient care changes; and third, adverse events avoided. The outcomes were examined in relation to four information access methods: first, asking librarian for assistance; second, performing search in a physical library; third, searching library's web site; or fourth, searching library resources on an institutional intranet. All library access methods had consistently positive relationships with the clinical outcomes, providing evidence that library services have a positive impact on patient care quality. Originality/value – Electronic collections and services provided by the library and the librarian contribute to patient care quality.

Application of Intelligence Control in Agriculture Greenhouses

2015 ◽  
Vol 719-720 ◽  
pp. 293-297 ◽  
Author(s):  
Hui Guo Lu ◽  
Cong Ying Li ◽  
Juan Ping Jiang
Keyword(s):  
Data Acquisition ◽  
Large Scale ◽  
Low Cost ◽  
Information Access ◽  
Intelligent Monitoring ◽  
Communication Technique ◽  
Using Data ◽  
National Industry ◽  
And Control ◽  
Greenhouse Control

Agriculture is the foundation of the national economy, and the guarantee of national industry. Greenhouse can grow counter-season production of crops and bring higher profits to farmers. But in our country the informatization level of agricultural is low. By using data acquisition technology, wireless communication technique and computer technology, this project can make intelligent monitoring, management and control of the large-scale plastic greenhouse come true and make agricultural information access and remote data transmission and exchange automated. The project is of simple circuit, low cost, good maintainability, and the expected results (the management of the greenhouse control) is operating conveniently and hommization, which can reduce a lot of manual work. It is expected to be widely popularized in agricultural plastic greenhouses in China. Key words:Intelligent Agriculture; Automation; Data acquisition; Sensors;

Intelligent Information Integration

2011 ◽  
pp. 241-261
Author(s):  
Naveen Ashish ◽  
David A. Maluf
Keyword(s):  
Information Integration ◽  
Large Scale ◽  
Information Access ◽  
Cost Effective ◽  
Demand System ◽  
Context Sensitive ◽  
Design And Implementation ◽  
Large Scale Integration ◽  
Intelligent Information ◽  
Scale Integration

The authors present their work in the conceptualization, design, implementation, and application of “lean” information integration systems. They present a new data integration approach based on a schema-less data management and integration paradigm, which enables developing cost-effective large scale integration applications. They have designed and developed a highly scalable, information-on-demand system called NETMARK, which facilitates information access and integration based on a theory of articulation management and a context sensitive paradigm. NETMARK has been widely deployed for managing, storing, and searching unstructured or semi-structured arbitrary XML and HTML information at the National Aeronautics Space Administration (NASA). In this paper the authors describe the theory, design and implementation of our system, present experimental benchmark evaluations, and validate our approach through real-world applications in the NASA enterprise. [Article copies are available for purchase from InfoSci-on-Demand.com]

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