Health Promoting Activities of Nigella sativa Seed Extracts

2020 ◽  
pp. 521-537
Author(s):  
Arzu Kart ◽  
Ebru Aydın
Keyword(s):  
Nigella Sativa ◽  
Health Promoting ◽  
Nigella Sativa Seed ◽  
Seed Extracts

Exploring anti-yeast activity of Nigella sativa seed extracts

2015 ◽  
Vol 77 ◽  
pp. 624-630 ◽  
Author(s):  
N.H. Nadaf ◽  
S.S. Gawade ◽  
A.S. Muniv ◽  
S.R. Waghmare ◽  
D.B. Jadhav ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Nigella Sativa Seed ◽  
Seed Extracts

scholarly journals Assessment of Quinone Enriched Fraction in Nigella sativa Seed Extracts

2020 ◽  
Vol 11 (2) ◽  
pp. 1505-1510
Author(s):  
Durga B ◽  
Durga B ◽  
Dass Prakash M V ◽  
Julius A
Keyword(s):  
High Performance ◽  
Nigella Sativa ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Bioactive Compound ◽  
New Drugs ◽  
Natural Sources ◽  
Ethanolic Extracts ◽  
Nigella Sativa Seed ◽  
Seed Extracts

In recent days, the thirst for the identification of the potential bioactive compounds from the natural sources like medicinal plants is on continuous demand. Among scientists and academicians, it has created many interdisciplinary platforms for research in establishing new drugs from the natural sources. According to many recent studies, Nigella sativa is believed to be the rich source of quinone, an effective bioactive compound with lots of medicinal values. The purpose of this study was to isolate and estimate the quinone in Nigella sativa seed extracts (aqueous and ethanol). Based on the qualitative and quantitative determination, the extracts were further focused for isolation of quinone from both aqueous and ethanolic  extracts of Nigella sativa. The isolated compound is identified by thin layer chromatography and purity is analyzed in High performance liquid chromatography. From the results we obtained, it was very clear that among the aqueous and ethanolic extracts of Nigella sativa, the ethanolic extract has been found with the highest quantity of quinine. This would be predicting that the ethanol extract of Nigella sativa may have good efficacy of pharmacological and therapeutic potentials like antidiabetic, anticancer, antimicrobial, anti-inflammatory properties when compared with the aqueous extract due to the presence of more quinone.

scholarly journals Synthesis of silver nanoparticles using Nigella sativa seed extracts and assessment of their antibacterial activity

2020 ◽  
Vol 11 (2) ◽  
pp. 2525-2532
Author(s):  
Sheik Shehensha ◽  
Jyothi M V
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Streptococcus Pyogenes ◽  
Nigella Sativa ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Resistant Strains ◽  
Nigella Sativa Seed ◽  
Seed Extracts

Silver nanoparticles were biosynthesized from Nigella sativa seed extracts using ethanol and chloroform. The antibacterial activity of silver nanoparticles against some drug-resistant bacteria has been established, but further study is needed to assess whether these particles could be an option for the treatment and prevention of drug-resistant microbial infections. Synthesized nanoparticles were characterized and screened for their antibacterial properties on resistant strains. The biosynthesized silver nanoparticles were characterized by UV-Visible, FTIR, Dynamic light scattering and Scanning Electron Microscope (SEM) analysis. The antibacterial action of biosynthesized silver nanoparticles was assessed by Microtitre Broth dilution process using Ciprofloxacin as standard, against resistant strains like Pseudomonas aeruginosa, Clostridium difficile, Klebsiella pneumoniae and Streptococcus pyogenes. The Silver nanoparticles obtained from chloroform extract of Nigella sativa seeds were more effective against Pseudomonas aeuruginosa, Clostridium difficile and Streptococcus pyogenes; than ethanolic seed extracts at 120 µL. Our data propose that the silver nanoparticles are effective against a variety of drug-resistant bacteria, which makes them a potential candidate for use in pharmaceutical products that may help to treat drug-resistant pathogens in different clinical environments. The present study focuses on the ability of phytoconstituents capped with silver nitrate can be used to treat infections caused by resistant bacteria

Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets

2004 ◽  
Vol 18 (5) ◽  
pp. 525-529 ◽  
Author(s):  
Halima Rchid ◽  
Hugues Chevassus ◽  
Rachid Nmila ◽  
Carine Guiral ◽  
Pierre Petit ◽  
...  
Keyword(s):  
Insulin Release ◽  
Nigella Sativa ◽  
Langerhans Islets ◽  
Nigella Sativa Seed ◽  
Seed Extracts

Inhibitory Roles of Nigella sativa seed extracts on in vitro glycation and aggregation

2021 ◽  
Vol 17 (6) ◽  
pp. 220
Author(s):  
Ahmad Ali ◽  
Umme Rubab ◽  
Dinesh Kumar ◽  
MohammadAbul Farah ◽  
KhalidMashay Al-Anazi ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Nigella Sativa Seed ◽  
Seed Extracts

scholarly journals Antibacterial and Antibiofilm Activities of Nigella sativa L. Seed Extracts

2021 ◽  
Vol 38 (1) ◽  
pp. 7-13
Author(s):  
Md Shafiqur Rahman ◽  
Tithi Roy
Keyword(s):  
Petroleum Ether ◽  
Biofilm Formation ◽  
Nigella Sativa ◽  
Petroleum Ether Extract ◽  
Antibacterial Activities ◽  
Disc Diffusion ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Nigella Sativa Seed ◽  
Seed Extracts

The emergence of antibiotic-resistant bacteria is a major public health problem. Consequently, the development of new antimicrobials that act on novel bacterial targets and are less susceptible to resistance are of primary importance to researchers in academia and industry alike. The present study was aimed to determine the antimicrobial and antibiofilm activities of Nigella sativa seed extracts. For this, primary (qualitative) and quantitative antibacterial activities of Nigella sativa seed extracts were determined against ten human pathogenic bacteria including four biofilm producing bacterial strains Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. The antibacterial activities as well as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extracts were evaluated using disc diffusion and macro-broth dilution methods, respectively. The seed extracts of N. sativa exhibited the highest extract yields (w/v) 23.3% and 21.35% with ethanol and petroleum ether, respectively. The crude extract (essential oil) of petroleum ether exhibited superior antibacterial activity (36 mm in diameter zone of inhibition) against biofilm forming E. coli on a disc diffusion assay at a concentration of 1000 μg/disc when compared to that of ethanolic crude extract. Moreover, the lowest MIC and MBC values were determined as 500 μg/ml and 1500 μg/ml respectively with the same petroleum ether extract against E. coli. However, N. sativa essential oil obtained from petroleum ether extract of seed inhibited 94% biofilm formation of E. coli at 2×MIC concentration. Moreover, at the same concentration (2×MIC), the ethanol extract inhibited 56% biofilm formation of P. aeruginosa. These results consistently revealed that it is possible to isolate novel antimicrobial agents capable of completely eradicating microbial infections including antibiotic resistance. Therefore, bioactive natural products present in plant resources would represent a noteworthy alternative to commercial antibiotics helping treatment of human antibiotic resistant infections. Bangladesh J Microbiol, Volume 38, Number 1, June 2021, pp 7-13

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