scholarly journals Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

2019 ◽  
pp. 219-235
Author(s):  
David Alba‑Molina ◽  
Juan J. Giner‑Casares ◽  
Manuel Cano
Keyword(s):  
Skin Penetration ◽  
Plasmonic Nanoparticles

scholarly journals Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

2019 ◽  
Vol 378 (1) ◽  
Author(s):  
David Alba-Molina ◽  
Juan J. Giner-Casares ◽  
Manuel Cano
Keyword(s):  
Skin Penetration ◽  
Plasmonic Nanoparticles

Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review

2020 ◽  
Vol 17 (4) ◽  
pp. 270-278
Author(s):  
Maha Nasr ◽  
Rawan Al-Karaki
Keyword(s):  
Side Effects ◽  
Therapeutic Efficacy ◽  
Skin Permeation ◽  
Skin Penetration ◽  
Topical Delivery ◽  
Natural Compounds ◽  
Therapeutic Activity ◽  
Dermatological Diseases ◽  
Anti Inflammatory ◽  
Topical Applications

Nanotechnology is currently a hot topic in dermatology and nutraceutical/cosmeceutical delivery, owing to the advantages it provides in terms of enhancing the skin permeation of drugs, as well as increasing their therapeutic efficacy in the treatment of different dermatological diseases. There is also a great interest in the topical delivery of nutraceuticals; which are natural compounds with both therapeutic and cosmetic benefits, in order to overcome the side effects of topically applied chemical drugs. Quercetin is a key nutraceutical with topical antioxidant and anti-inflammatory properties which was reported to be effective in the treatment of different dermatological diseases, however, its topical therapeutic activity is hindered by its poor skin penetration. This review highlights the topical applications of quercetin, and summarizes the nanocarrier-based solutions to its percutaneous delivery challenges.

Status of Fatty Acids as Skin Penetration Enhancers-A Review

2009 ◽  
Vol 6 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Ashu Mittal ◽  
U. Sara ◽  
Asgar Ali ◽  
Mohd. Aqil
Keyword(s):  
Fatty Acids ◽  
Skin Penetration ◽  
Penetration Enhancers

Green Synthesis of Copper Oxide Nanoparticles using Cucumis sativus (cucumber) Extracts and their Bio-physical and Biochemical Characterization for Cosmetic and Dermatologic Applications

2020 ◽  
Vol 20 ◽  
Author(s):  
Monika Vats ◽  
Shruti Bhardwaj ◽  
Arvind Chhabra
Keyword(s):  
Copper Oxide ◽  
Green Synthesis ◽  
Biochemical Characterization ◽  
Chemical Characterization ◽  
Ultra Violet ◽  
Skin Penetration ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ultra Violet Radiation ◽  
Anti Fungal

Background & Objective: Nanoparticles are used in cosmetic and dermatologic products, due to better skin penetration properties. Incorporation of natural products exhibiting medicinal properties in nano-preparations could significantly improve efficacy of these products and improve the quality of life without the side effects of synthetic formulations. Methods: We here report green synthesis of Copper Oxide nanoparticles, using Cucumber extract, and their detailed biophysical and bio-chemical characterization. Results: These Copper Oxide-Cucumber nanoparticles exhibit significant anti-bacterial and anti-fungal properties, Ultra Violet-radiation protection ability and reactive-oxygen species inhibition properties. Importantly, these nanoparticles do not exhibit significant cellular toxicity and, when incorporated in skin cream, exhibit skin rejuvenating properties. Conclusion: Our findings have implications for nanoparticle-based cosmetics and dermatologic applications.

scholarly journals Toxicological Profile of Plasmonic Nanoparticles in Zebrafish Model

2021 ◽  
Vol 22 (12) ◽  
pp. 6372
Author(s):  
Marta d’Amora ◽  
Vittoria Raffa ◽  
Francesco De Angelis ◽  
Francesco Tantussi
Keyword(s):  
Surface Plasmon Resonance ◽  
Adverse Effects ◽  
Physicochemical Properties ◽  
Surface Plasmon ◽  
Danio Rerio ◽  
Plasmonic Nanoparticles ◽  
Comprehensive Understanding ◽  
Zebrafish Model ◽  
Toxicological Profile ◽  
Materials Used

Plasmonic nanoparticles are increasingly employed in several fields, thanks to their unique, promising properties. In particular, these particles exhibit a surface plasmon resonance combined with outstanding absorption and scattering properties. They are also easy to synthesize and functionalize, making them ideal for nanotechnology applications. However, the physicochemical properties of these nanoparticles can make them potentially toxic, even if their bulk metallic forms are almost inert. In this review, we aim to provide a more comprehensive understanding of the potential adverse effects of plasmonic nanoparticles in zebrafish (Danio rerio) during both development and adulthood, focusing our attention on the most common materials used, i.e., gold and silver.

scholarly journals Ultrasound-Guided Popliteal Nerve Block with Short-Acting Lidocaine in the Surgical Treatment of Ingrown Toenails

2021 ◽  
Vol 18 (10) ◽  
pp. 5059
Author(s):  
Beom Suk Kim ◽  
Kyungho Kim ◽  
Jonathan Day ◽  
Jesse Seilern Und Seilern Und Aspang ◽  
Jaeyoung Kim
Keyword(s):  
Surgical Treatment ◽  
Adverse Events ◽  
Nerve Block ◽  
Skin Penetration ◽  
Sensory Block ◽  
Foot And Ankle ◽  
Ingrown Toenail ◽  
Ankle Surgery ◽  
Ingrown Toenails ◽  
Digital Nerve Block

Background: Digital nerve block (DB) is a commonly utilized anesthetic procedure in ingrown toenail surgery. However, severe procedure-related pain has been reported. Although the popliteal sciatic nerve block (PB) is widely accepted in foot and ankle surgery, its use in ingrown toenail surgery has not been reported. Therefore, this study aimed to investigate the safety and effectiveness of PB in the surgical treatment of ingrown toenails. Methods: One-hundred-ten patients surgically treated for an ingrown toenail were enrolled. Sixty-six patients underwent DB, and 44 underwent PB. PB was performed under ultrasound-guidance via a 22-gauge needle with 15 mL of 1% lidocaine in the popliteal region. The visual analogue scale was used to assess pain at two-time points: pain with skin penetration and pain with the solution injection. Time to sensory block, duration of sensory block, need for additional injections, and adverse events were recorded. Results: PB group demonstrated significantly lower procedure-related pain than the DB group. Time to sensory block was significantly longer in the PB group (20.8 ± 4.6 versus 6.5 ± 1.6 minutes). The sensory block duration was significantly longer in the PB group (187.9 ± 22.0 versus 106.5 ± 19.1 minutes). Additional injections were required in 16 (24.2%) DB cases, while no additional injections were required in PB cases. Four adverse events occurred in the DB group and two in the PB group. Conclusion: PB was a less painful anesthetic procedure associated with a longer sensory block duration and fewer repeat injections compared with DB. The result of this study implicates that PB can be an alternative anesthetic option in the surgical treatment of ingrown toenails.

scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

An overview of enhanced polymer solar cells with embedded plasmonic nanoparticles

2021 ◽  
Vol 141 ◽  
pp. 110726
Author(s):  
Muheeb Ahmad Alkhalayfeh ◽  
Azlan Abdul Aziz ◽  
Mohd Zamir Pakhuruddin
Keyword(s):  
Solar Cells ◽  
Polymer Solar Cells ◽  
Plasmonic Nanoparticles
Sign in / Sign up

Export Citation Format

Share Document