Reclaiming the Biological Design Argument: A Preposterous and Dangerous Idea?

Author(s):  
E. V. R. Kojonen
2008 ◽  
Vol 44 (1) ◽  
pp. 99-110 ◽  
Author(s):  
TRENT DOUGHERTY ◽  
TED POSTON

AbstractWe argue that there is a tension between two types of design arguments: the fine-tuning argument (FTA) and the biological design argument (BDA). The tension arises because the strength of each argument is inversely proportional to the value of a certain currently unknown probability. Since the value of that probability is currently unknown, we investigate the properties of the FTA and BDA on different hypothetical values of this probability. If our central claim is correct this suggests three results: (1) It is not very plausible that a cumulative case for theism include both the FTA and the BDA (with one possible qualification); (2) Self-organization scenarios do not threaten theism but in fact provide the materials for a good FTA; (3) A plausible design argument of one sort or another (either FTA or BDA) will be available for a wide variety of values of the key probability.


2003 ◽  
Vol 154 (12) ◽  
pp. 498-503 ◽  
Author(s):  
Ingo Burgert

Three investigations into the mechanical relevance of wood rays were combined for this article. The main objective was to show, that, apart from physiological functions, rays also significantly influence the radial strength and stiffness of wood. In the first approach twelve deciduous tree species with various proportions of fractions of rays were examined for their transverse tensile strength and stiffness. The second approach was based on the comparison of the radial mechanical properties of wood with a very high proportion of fraction of rays and beech wood with a normal volume. In these two investigations the mechanical relevance of rays could only be deduced indirectly. By isolating big rays of beech and carrying out tensile tests on the tissue, we found direct evidence for the mechanical relevance. The results are discussed with regard to their biomechanical relevance. The importance of a radial reinforcement for the wood is underlined. Moreover, the principle of multi-functionality in nature is emphasized in keeping with a possible transfer of biological design to technical solutions.


Pro Ecclesia ◽  
2021 ◽  
Vol 30 (2) ◽  
pp. 177-215
Author(s):  
Paul Gondreau

Thomas Aquinas offers for his time a novel take on human sexual difference, in that he grounds human sexuality in what we might term a metaphysical biology and accords it a privileged role in the moral life. Though his biology is drawn from Aristotle, which leads Aquinas to make problematic statements on sexual difference, he nonetheless offers a perspective that remains deeply relevant and significant for today. His method or approach of tethering sexual difference first and foremost to our animal-like biological design remains perennial, particularly at a time when many seek to dismiss biology as irrelevant to sexual identity and gender difference. The latest findings of the emerging field of neurobiology, which have uncovered structural differences between the male and female brains, offer key support to Aquinas’s approach. Even more important, he holds, in an unprecedented move, that sexual design and inclination provide a veritable source of moral excellence. He goes so far as to locate the mean of virtue in our sexual design and appetites.


2018 ◽  
Vol 15 (147) ◽  
pp. 20180086 ◽  
Author(s):  
Dan M. Popescu ◽  
Sean X. Sun

One of the biggest perceived challenges in building megastructures, such as the space elevator, is the unavailability of materials with sufficient tensile strength. The presumed necessity of very strong materials stems from a design paradigm which requires structures to operate at a small fraction of their maximum tensile strength (usually, 50% or less). This criterion limits the probability of failure by giving structures sufficient leeway in handling stochastic components, such as variability in material strength and/or external forces. While reasonable for typical engineering structures, low working stress ratios—defined as operating stress as a fraction of ultimate tensile strength—in the case of megastructures are both too stringent and unable to adequately control the failure probability. We draw inspiration from natural biological structures, such as bones, tendons and ligaments, which are made up of smaller substructures and exhibit self-repair, and suggest a design that requires structures to operate at significantly higher stress ratios, while maintaining reliability through a continuous repair mechanism. We outline a mathematical framework for analysing the reliability of structures with components exhibiting probabilistic rupture and repair that depend on their time-in-use (age). Further, we predict time-to-failure distributions for the overall structure. We then apply this framework to the space elevator and find that a high degree of reliability is achievable using currently existing materials, provided it operates at sufficiently high working stress ratios, sustained through an autonomous repair mechanism, implemented via, e.g. robots.


2011 ◽  
Vol 18 (1) ◽  
pp. 53-90 ◽  
Author(s):  
Koichi Masaki ◽  
Kazuhiro Maeda ◽  
Hiroyuki Kurata

To synthesize natural or artificial life, it is critically important to understand the design principles of how biochemical networks generate particular cellular functions and evolve complex systems in comparison with engineering systems. Cellular systems maintain their robustness in the face of perturbations arising from environmental and genetic variations. In analogy to control engineering architectures, the complexity of modular structures within a cell can be attributed to the necessity of achieving robustness. To reveal such biological design, the E. coli ammonia assimilation system is analyzed, which consists of complex but highly structured modules: the glutamine synthetase (GS) activity feedback control module with bifunctional enzyme cascades for catalyzing reversible reactions, and the GS synthesis feedback control module with positive and negative feedback loops. We develop a full-scale dynamic model that unifies the two modules, and we analyze its robustness and fine tuning with respect to internal and external perturbations. The GS activity control is added to the GS synthesis module to improve its transient response to ammonia depletion, compensating the tradeoffs of each module, but its robustness to internal perturbations is lost. These findings suggest some design principles necessary for the synthesis of life.


2020 ◽  
Vol 8 (12) ◽  
pp. 2050
Author(s):  
Daniel Craig Zielinski ◽  
Arjun Patel ◽  
Bernhard O. Palsson

Microbial strains are being engineered for an increasingly diverse array of applications, from chemical production to human health. While traditional engineering disciplines are driven by predictive design tools, these tools have been difficult to build for biological design due to the complexity of biological systems and many unknowns of their quantitative behavior. However, due to many recent advances, the gap between design in biology and other engineering fields is closing. In this work, we discuss promising areas of development of computational tools for engineering microbial strains. We define five frontiers of active research: (1) Constraint-based modeling and metabolic network reconstruction, (2) Kinetics and thermodynamic modeling, (3) Protein structure analysis, (4) Genome sequence analysis, and (5) Regulatory network analysis. Experimental and machine learning drivers have enabled these methods to improve by leaps and bounds in both scope and accuracy. Modern strain design projects will require these tools to be comprehensively applied to the entire cell and efficiently integrated within a single workflow. We expect that these frontiers, enabled by the ongoing revolution of big data science, will drive forward more advanced and powerful strain engineering strategies.


2020 ◽  
Vol 56 (3) ◽  
pp. 51-70
Author(s):  
Juuso Loikkanen

Some features within the physical universe appear to be so well-ordered that they have been regarded as evidence of the existence of a supernatural being who has designed them. This history of the so-called design argument is millennia-long, and various formulations of the argument have been presented. In this paper, I explore one contemporary version of the design argument proposed by the Intelligent Design movement, and analyze its advantages and disadvantages in comparison to one of the most famous classical versions of the argument.


2009 ◽  
Vol 25 (3) ◽  
pp. 379-389 ◽  
Author(s):  
Gregory J. Morgan
Keyword(s):  

2018 ◽  
Vol 02 (01) ◽  
pp. 9-18 ◽  
Author(s):  
Frances H. Arnold

Not satisfied with nature’s vast enzyme repertoire, we want to create new ones and expand the space of genetically encoded enzyme functions. We use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Mimicking nature’s evolutionary tricks and using a little chemical intuition, we can generate whole new enzyme families that catalyze important reactions, including ones not known in biology. These new capabilities increase the scope of molecules and materials we can build using biology.


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