Tunneling Nanotubes

2010 ◽  
pp. 170-171
Author(s):  
Margit Pavelka ◽  
Jürgen Roth
Keyword(s):  
Tunneling Nanotubes

Progress in promoting mechanism of tunneling nanotubes formation

2015 ◽  
Vol 36 (11) ◽  
pp. 1229
Author(s):  
Xiao-qing WANG ◽  
Xiao-wen YU ◽  
Ming-yuan LIU ◽  
Yang-tai GUAN
Keyword(s):  
Tunneling Nanotubes

scholarly journals Mitochondrial Transfer in Cancer: A Comprehensive Review

2021 ◽  
Vol 22 (6) ◽  
pp. 3245
Author(s):  
Luca X. Zampieri ◽  
Catarina Silva-Almeida ◽  
Justin D. Rondeau ◽  
Pierre Sonveaux
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Metabolic Pathways ◽  
Current Knowledge ◽  
Cancer Cell Proliferation ◽  
Tunneling Nanotubes ◽  
Comprehensive Review ◽  
Cancer Cell Death ◽  
Mitochondrial Transfer ◽  
Metabolic Activities

Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental influences, cancer cells cover a broad range of metabolic activities that fluctuate over time and space. At the core of most metabolic pathways, mitochondria are essential organelles that participate in energy and biomass production, act as metabolic sensors, control cancer cell death, and initiate signaling pathways related to cancer cell migration, invasion, metastasis and resistance to treatments. While some mitochondrial modifications provide aggressive advantages to cancer cells, others are detrimental. This comprehensive review summarizes the current knowledge about mitochondrial transfers that can occur between cancer and nonmalignant cells. Among different mechanisms comprising gap junctions and cell-cell fusion, tunneling nanotubes are increasingly recognized as a main intercellular platform for unidirectional and bidirectional mitochondrial exchanges. Understanding their structure and functionality is an important task expected to generate new anticancer approaches aimed at interfering with gains of functions (e.g., cancer cell proliferation, migration, invasion, metastasis and chemoresistance) or damaged mitochondria elimination associated with mitochondrial transfer.

Two routes of direct intercellular communication in brain cancer

2021 ◽  
Vol 478 (6) ◽  
pp. 1283-1286
Author(s):  
Daniel D. Azorín ◽  
Frank Winkler
Keyword(s):  
Tumor Cells ◽  
Brain Cancer ◽  
State Of The Art ◽  
Tumor Resistance ◽  
Tunneling Nanotubes ◽  
Functional Studies ◽  
Membrane Tube ◽  
Biochemical Journal ◽  
Culture Model ◽  
Health And Disease

Glioblastoma is a particularly challenging disease characterized by the connection of tumor cells to functional multicellular networks that effectively resist therapies. In this issue of Biochemical Journal, Pinto et al. report the discovery of two distinct classes of intercellular membrane tube connections, tunneling nanotubes and tumor microtubes, in the same state-of-the-art culture model of patient-derived glioblastoma material. These findings contribute to our understanding of the heterogeneity of intercellular membrane tubes in health and disease, and pave the way for future functional studies on their various roles for disease progression and tumor resistance.

scholarly journals Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells

2017 ◽  
Vol 58 (12) ◽  
pp. 5298 ◽  
Author(s):  
Kate E. Keller ◽  
John M. Bradley ◽  
Ying Ying Sun ◽  
Yong-Feng Yang ◽  
Ted S. Acott
Keyword(s):  
Trabecular Meshwork ◽  
Cellular Structures ◽  
Tunneling Nanotubes ◽  
Trabecular Meshwork Cells

scholarly journals Investigating tunneling nanotubes in ovariancancer based on two-photon excitation FLIMFRET

2021 ◽  
Author(s):  
ShiQi Wang ◽  
yanping li ◽  
Yihua zhao ◽  
Fangrui Lin ◽  
Junle Qu ◽  
...  
Keyword(s):  
Tunneling Nanotubes ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

scholarly journals Intra- and Intercellular Quality Control Mechanisms of Mitochondria

2017 ◽  
Author(s):  
Yoshimitsu Kiriyama ◽  
Hiromi Nochi
Keyword(s):  
Quality Control ◽  
Cell Death ◽  
Extracellular Vesicles ◽  
Mitochondrial Function ◽  
Current Knowledge ◽  
Control Mechanisms ◽  
Tunneling Nanotubes ◽  
Cellular Homeostasis

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.

scholarly journals Pathogenic Stress Induces Human Monocyte to Express an Extracellular Web of Tunneling Nanotubes

2021 ◽  
Vol 12 ◽  
Author(s):  
Michal Shahar ◽  
Auryan Szalat ◽  
Haim Rosen
Keyword(s):  
Intercellular Communication ◽  
Environmental Changes ◽  
Imaging System ◽  
Human Monocyte ◽  
Cell Types ◽  
Similar Response ◽  
Human Monocytes ◽  
Tunneling Nanotubes ◽  
Membrane Components

Actin-based tunneling nanotubes are a means of intercellular communication between remote cells. In the last decade, this type of nanotube was described in a wide variety of cell types and it became widely accepted that communication through these nanotubes is related to response to environmental changes. Few reports, however, are available regarding the expression of similar nanotubes in vivo or in primary cells. Moreover, the functional significance of this intercellular communication for health and disease is largely unknown. In this context, and as a first step in unraveling these questions, we examined the formation of similar nanotubes in primary peripheral human monocytes. To that end, we combined the use of a live cell imaging system along with advanced methods of fluorescent and scanning electron microscopy. This experimental approach reveals for the first time that the bacterial lipopolysaccharide endotoxin induces a transient expression of an unexpected abundance of actin-based tunneling nanotubes associated with vesicles. In addition, it was found that a similar response can be achieved by treating human monocytes with various bacterial and yeast membrane components, as well as with a viral component analog. In all these cases, this response is mediated by distinct complexes of toll-like receptors. Therefore, we suggest that the observed phenomena are related to a broad type of monocyte pathogen response, and raise the possibility that the phenomena described above may be involved in many clinical situations related to inflammation as a new topic of study.

scholarly journals Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 15539-15552 ◽  
Author(s):  
Jinjin Lu ◽  
Xiufen Zheng ◽  
Fan Li ◽  
Yang Yu ◽  
Zhong Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Tunneling Nanotubes ◽  
Bladder Cancer Cells ◽  
Mitochondria Transfer
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