Machine Learning Methods for Mortality Prediction of Polytraumatized Patients in Intensive Care Units – Dealing with Imbalanced and High-Dimensional Data

2014 ◽  
pp. 309-317 ◽  
Author(s):  
María N. Moreno García ◽  
Javier González Robledo ◽  
Félix Martín González ◽  
Fernando Sánchez Hernández ◽  
Mercedes Sánchez Barba
Keyword(s):  
Machine Learning ◽  
Intensive Care ◽  
Intensive Care Units ◽  
High Dimensional Data ◽  
Mortality Prediction ◽  
High Dimensional ◽  
Learning Methods ◽  
Machine Learning Methods

scholarly journals Sparse Boosting Based Machine Learning Methods for High-Dimensional Data

2021 ◽  
Author(s):  
Mu Yue
Keyword(s):  
Machine Learning ◽  
Parameter Estimation ◽  
Variable Selection ◽  
Survival Data ◽  
High Dimensional Data ◽  
High Dimensional ◽  
Learning Methods ◽  
Require Time ◽  
Machine Learning Methods ◽  
Boosting Method

In high-dimensional data, penalized regression is often used for variable selection and parameter estimation. However, these methods typically require time-consuming cross-validation methods to select tuning parameters and retain more false positives under high dimensionality. This chapter discusses sparse boosting based machine learning methods in the following high-dimensional problems. First, a sparse boosting method to select important biomarkers is studied for the right censored survival data with high-dimensional biomarkers. Then, a two-step sparse boosting method to carry out the variable selection and the model-based prediction is studied for the high-dimensional longitudinal observations measured repeatedly over time. Finally, a multi-step sparse boosting method to identify patient subgroups that exhibit different treatment effects is studied for the high-dimensional dense longitudinal observations. This chapter intends to solve the problem of how to improve the accuracy and calculation speed of variable selection and parameter estimation in high-dimensional data. It aims to expand the application scope of sparse boosting and develop new methods of high-dimensional survival analysis, longitudinal data analysis, and subgroup analysis, which has great application prospects.

scholarly journals Predicting Risk of Mortality in Pediatric ICU Based on Ensemble Step-Wise Feature Selection

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Shenda Hong ◽  
Xinlin Hou ◽  
Jin Jing ◽  
Wendong Ge ◽  
Luxia Zhang
Keyword(s):  
Machine Learning ◽  
Intensive Care ◽  
Mortality Prediction ◽  
Ranking And Selection ◽  
Data Driven ◽  
Feature Ranking ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Pediatric Icu ◽  
Logistic Regression Classifier

Background. Prediction of mortality risk in intensive care units (ICU) is an important task. Data-driven methods such as scoring systems, machine learning methods, and deep learning methods have been investigated for a long time. However, few data-driven methods are specially developed for pediatric ICU. In this paper, we aim to amend this gap—build a simple yet effective linear machine learning model from a number of hand-crafted features for mortality prediction in pediatric ICU. Methods. We use a recently released publicly available pediatric ICU dataset named pediatric intensive care (PIC) from Children’s Hospital of Zhejiang University School of Medicine in China. Unlike previous sophisticated machine learning methods, we want our method to keep simple that can be easily understood by clinical staffs. Thus, an ensemble step-wise feature ranking and selection method is proposed to select a small subset of effective features from the entire feature set. A logistic regression classifier is built upon selected features for mortality prediction. Results. The final predictive linear model with 11 features achieves a 0.7531 ROC-AUC score on the hold-out test set, which is comparable with a logistic regression classifier using all 397 features (0.7610 ROC-AUC score) and is higher than the existing well known pediatric mortality risk scorer PRISM III (0.6895 ROC-AUC score). Conclusions. Our method improves feature ranking and selection by utilizing an ensemble method while keeping a simple linear form of the predictive model and therefore achieves better generalizability and performance on mortality prediction in pediatric ICU.

scholarly journals A Comparison of Machine Learning Methods in a High-Dimensional Classification Problem

2014 ◽  
Vol 5 (3) ◽  
pp. 82-96 ◽  
Author(s):  
Marijana Zekić-Sušac ◽  
Sanja Pfeifer ◽  
Nataša Šarlija
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Classification Accuracy ◽  
Classification Problem ◽  
High Dimensional ◽  
Nearest Neighbour ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Dimensional Classification ◽  
Artificial Neural

Abstract Background: Large-dimensional data modelling often relies on variable reduction methods in the pre-processing and in the post-processing stage. However, such a reduction usually provides less information and yields a lower accuracy of the model. Objectives: The aim of this paper is to assess the high-dimensional classification problem of recognizing entrepreneurial intentions of students by machine learning methods. Methods/Approach: Four methods were tested: artificial neural networks, CART classification trees, support vector machines, and k-nearest neighbour on the same dataset in order to compare their efficiency in the sense of classification accuracy. The performance of each method was compared on ten subsamples in a 10-fold cross-validation procedure in order to assess computing sensitivity and specificity of each model. Results: The artificial neural network model based on multilayer perceptron yielded a higher classification rate than the models produced by other methods. The pairwise t-test showed a statistical significance between the artificial neural network and the k-nearest neighbour model, while the difference among other methods was not statistically significant. Conclusions: Tested machine learning methods are able to learn fast and achieve high classification accuracy. However, further advancement can be assured by testing a few additional methodological refinements in machine learning methods.

scholarly journals TADA: phylogenetic augmentation of microbiome samples enhances phenotype classification

2019 ◽  
Vol 35 (14) ◽  
pp. i31-i40 ◽  
Author(s):  
Erfan Sayyari ◽  
Ban Kawas ◽  
Siavash Mirarab
Keyword(s):  
Machine Learning ◽  
Sample Size ◽  
Data Augmentation ◽  
Training Data ◽  
Supplementary Information ◽  
High Dimensional ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Phenotype Classification ◽  
Microbiome Data

Abstract Motivation Learning associations of traits with the microbial composition of a set of samples is a fundamental goal in microbiome studies. Recently, machine learning methods have been explored for this goal, with some promise. However, in comparison to other fields, microbiome data are high-dimensional and not abundant; leading to a high-dimensional low-sample-size under-determined system. Moreover, microbiome data are often unbalanced and biased. Given such training data, machine learning methods often fail to perform a classification task with sufficient accuracy. Lack of signal is especially problematic when classes are represented in an unbalanced way in the training data; with some classes under-represented. The presence of inter-correlations among subsets of observations further compounds these issues. As a result, machine learning methods have had only limited success in predicting many traits from microbiome. Data augmentation consists of building synthetic samples and adding them to the training data and is a technique that has proved helpful for many machine learning tasks. Results In this paper, we propose a new data augmentation technique for classifying phenotypes based on the microbiome. Our algorithm, called TADA, uses available data and a statistical generative model to create new samples augmenting existing ones, addressing issues of low-sample-size. In generating new samples, TADA takes into account phylogenetic relationships between microbial species. On two real datasets, we show that adding these synthetic samples to the training set improves the accuracy of downstream classification, especially when the training data have an unbalanced representation of classes. Availability and implementation TADA is available at https://github.com/tada-alg/TADA. Supplementary information Supplementary data are available at Bioinformatics online.

scholarly journals Mortality Prediction in Cerebral Hemorrhage Patients Using Machine Learning Algorithms in Intensive Care Units

2021 ◽  
Vol 11 ◽  
Author(s):  
Ximing Nie ◽  
Yuan Cai ◽  
Jingyi Liu ◽  
Xiran Liu ◽  
Jiahui Zhao ◽  
...  
Keyword(s):  
Machine Learning ◽  
Intensive Care ◽  
Random Forest ◽  
Hospital Mortality ◽  
Intensive Care Units ◽  
Cerebral Hemorrhage ◽  
Characteristic Curve ◽  
Learning Algorithms ◽  
Mortality Prediction ◽  
Machine Learning Algorithms

Objectives: This study aims to investigate whether the machine learning algorithms could provide an optimal early mortality prediction method compared with other scoring systems for patients with cerebral hemorrhage in intensive care units in clinical practice.Methods: Between 2008 and 2012, from Intensive Care III (MIMIC-III) database, all cerebral hemorrhage patients monitored with the MetaVision system and admitted to intensive care units were enrolled in this study. The calibration, discrimination, and risk classification of predicted hospital mortality based on machine learning algorithms were assessed. The primary outcome was hospital mortality. Model performance was assessed with accuracy and receiver operating characteristic curve analysis.Results: Of 760 cerebral hemorrhage patients enrolled from MIMIC database [mean age, 68.2 years (SD, ±15.5)], 383 (50.4%) patients died in hospital, and 377 (49.6%) patients survived. The area under the receiver operating characteristic curve (AUC) of six machine learning algorithms was 0.600 (nearest neighbors), 0.617 (decision tree), 0.655 (neural net), 0.671(AdaBoost), 0.819 (random forest), and 0.725 (gcForest). The AUC was 0.423 for Acute Physiology and Chronic Health Evaluation II score. The random forest had the highest specificity and accuracy, as well as the greatest AUC, showing the best ability to predict in-hospital mortality.Conclusions: Compared with conventional scoring system and the other five machine learning algorithms in this study, random forest algorithm had better performance in predicting in-hospital mortality for cerebral hemorrhage patients in intensive care units, and thus further research should be conducted on random forest algorithm.

scholarly journals Utilizing Machine Learning Methods for Preoperative Prediction of Postsurgical Mortality and Intensive Care Unit Admission

2019 ◽  
Vol 272 (6) ◽  
pp. 1133-1139 ◽  
Author(s):  
Calvin J. Chiew ◽  
Nan Liu ◽  
Ting Hway Wong ◽  
Yilin E. Sim ◽  
Hairil R. Abdullah
Keyword(s):  
Machine Learning ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Intensive Care Unit Admission ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Preoperative Prediction

Morphological classification of brains via high-dimensional shape transformations and machine learning methods

NeuroImage ◽  
2004 ◽  
Vol 21 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Zhiqiang Lao ◽  
Dinggang Shen ◽  
Zhong Xue ◽  
Bilge Karacali ◽  
Susan M. Resnick ◽  
...  
Keyword(s):  
Machine Learning ◽  
High Dimensional ◽  
Morphological Classification ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Shape Transformations ◽  
Dimensional Shape

scholarly journals Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer's disease across imaging databases

NeuroImage ◽  
2018 ◽  
Vol 183 ◽  
pp. 401-411 ◽  
Author(s):  
Ramon Casanova ◽  
Ryan T. Barnard ◽  
Sarah A. Gaussoin ◽  
Santiago Saldana ◽  
Kathleen M. Hayden ◽  
...  
Keyword(s):  
Machine Learning ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
High Dimensional ◽  
Learning Methods ◽  
Machine Learning Methods

scholarly journals Machine Learning Methods Applied to Predict Ventilator-Associated Pneumonia with Pseudomonas aeruginosa Infection via Sensor Array of Electronic Nose in Intensive Care Unit

Sensors ◽  
2019 ◽  
Vol 19 (8) ◽  
pp. 1866 ◽  
Author(s):  
Liao ◽  
Wang ◽  
Zhang ◽  
Abbod ◽  
Shih ◽  
...  
Keyword(s):  
Machine Learning ◽  
Intensive Care Unit ◽  
Pseudomonas Aeruginosa ◽  
Intensive Care ◽  
Prediction Models ◽  
Support Vector ◽  
Ventilator Associated Pneumonia ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Pseudomonas Aeruginosa Infection

One concern to the patients is the off-line detection of pneumonia infection status after using the ventilator in the intensive care unit. Hence, machine learning methods for ventilator-associated pneumonia (VAP) rapid diagnose are proposed. A popular device, Cyranose 320 e-nose, is usually used in research on lung disease, which is a highly integrated system and sensor comprising 32 array using polymer and carbon black materials. In this study, a total of 24 subjects were involved, including 12 subjects who are infected with pneumonia, and the rest are non-infected. Three layers of back propagation artificial neural network and support vector machine (SVM) methods were applied to patients’ data to predict whether they are infected with VAP with Pseudomonas aeruginosa infection. Furthermore, in order to improve the accuracy and the generalization of the prediction models, the ensemble neural networks (ENN) method was applied. In this study, ENN and SVM prediction models were trained and tested. In order to evaluate the models’ performance, a fivefold cross-validation method was applied. The results showed that both ENN and SVM models have high recognition rates of VAP with Pseudomonas aeruginosa infection, with 0.9479 ± 0.0135 and 0.8686 ± 0.0422 accuracies, 0.9714 ± 0.0131, 0.9250 ± 0.0423 sensitivities, and 0.9288 ± 0.0306, 0.8639 ± 0.0276 positive predictive values, respectively. The ENN model showed better performance compared to SVM in the recognition of VAP with Pseudomonas aeruginosa infection. The areas under the receiver operating characteristic curve of the two models were 0.9842 ± 0.0058 and 0.9410 ± 0.0301, respectively, showing that both models are very stable and accurate classifiers. This study aims to assist the physician in providing a scientific and effective reference for performing early detection in Pseudomonas aeruginosa infection or other diseases.

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