Volume Measurements and Follow-Up

Introduction: Developing accurate measurements of infarct volume is vital to studying outcomes in Perinatal Arterial Ischemic Stroke (PAS). Methods for measuring Acute Infarct Volumes (aIV) are well established in PAS. However, techniques for measuring chronic infarct volume (cIV) in order to estimate aIV have not been validated and must account for changes in Total Brain Volume (TBV) over time, as well as contraction of the infarct. We compared two methods of measuring cIV, hypothesizing that cIV extrapolated from residual uninfarcted brain tissue volume would better estimate aIV than direct measurement of cIV. Methods: Using modified manual segmentation techniques, two pediatric neuroradiologists independently measured the brain and infarct volumes of 10 PAS patients both on the acute (0-7 days old) and chronic (>3 months) MRIs. Volume measurements were averaged after high inter-rater reliability was established (ICC>0.9). We evaluated acute and chronic scans for changes in infarct anatomy, and excluded patients with bilateral infarctions. Method 1 for estimating cIV used a direct measurement of the infarct (figure). Method 2 extrapolated infarct volume from residual uninfarcted brain tissue (figure). The cIV for each method was then compared to the aIV. Results: 3 patients with bilateral infarcts were excluded. Infarct anatomy between acute and chronic scans did not change for the 7 unilateral infarcts evaluated. In these 7 cases, the ICC comparing aIV and cIV from Method 1 was 0.507 (CI -0.120, 0.891), while the ICC comparing aIV and cIV from Method 2 was 0.964 (CI 0.821, 0.994). cIV’s from Method 1 were smaller than the aIV’s in all cases, despite stability of infarct anatomy. Conclusions: In this pilot study measuring cIV in PAS, direct measurement of cIV likely underestimates volume because of contraction of infarcted tissue. In conclusion, extrapolation of cIV from measurement of residual uninfarcted tissue appears to accurately estimate aIV.

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Effect of mannitol on globe and orbital volumes in humans

European Journal of Ophthalmology ◽

10.5301/ejo.5001008 ◽

2018 ◽

Vol 28 (2) ◽

pp. 163-167 ◽

Cited By ~ 3

Author(s):

Adam C. Weber ◽

Alexander D. Blandford ◽

Bryan R. Costin ◽

Julian D. Perry

Keyword(s):

Volume Change ◽

Cleveland Clinic ◽

Retrospective Chart Review ◽

Consecutive Series ◽

Orbital Volume ◽

Computed Tomographic ◽

Before And After ◽

Pressure Lowering ◽

Volume Measurements

Purpose: To determine the effect of intravenous mannitol on globe and orbital volumes. Methods: Retrospective chart review of a consecutive series of Cleveland Clinic Neurosurgical Intensive Care Unit patients who underwent computed tomographic imaging before and after intravenous mannitol administration. Volume measurements were performed according to a previously described technique by averaging axial image areas. Measurements before and after mannitol administration were compared using paired t-test. Results: Fourteen patients (28 eyes) met inclusion criteria. Average globe volume decreased 186 mm3 (-2.5%, p = 0.02) after mannitol administration, while average orbital volume increased 353 mm3 (+3.5%, p = 0.04). Average globe volume change for subjects with follow-up scan less than 4.7 hours (mean 1.9 hours; range 0.2-4.5 hours) after mannitol administration was -125 mm3 (-1.7%, p = 0.24) and average orbital volume change was +458 mm3 (+5.1%, p = 0.11). Average globe volume change after mannitol administration for those with follow-up more than 4.7 hours (average 13.9 hours, range 4.9-24.7 hours) was -246 mm3 (-3.3%, p = 0.05) and orbital volume change was +248 mm3 (+2.2%, p = 0.24). Dividing the study population into groups based on mannitol dose did not yield any statistically significant change. Conclusions: Human globe volume decreases after intravenous mannitol administration, while orbital volume increases. These volume changes occur during the time period when intraocular pressure normalizes, after the pressure-lowering effects of the drug. This novel volumetric information improves our understanding of mannitol’s mechanism of action and its effects on human ocular and periocular tissues.

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Decision-making in follow-up after endovascular aneurysm repair based on diameter and volume measurements: A blinded comparison

European Journal of Vascular and Endovascular Surgery ◽

10.1053/ejvs.2002.1892 ◽

2003 ◽

Vol 26 (2) ◽

pp. 184-187 ◽

Cited By ~ 38

Author(s):

M. Prinssen ◽

E.L.G. Verhoeven ◽

H.J.M. Verhagen ◽

J.D. Blankensteijn

Keyword(s):

Decision Making ◽

Endovascular Aneurysm Repair ◽

Volume Measurements ◽

Aneurysm Repair

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Serial CT changes in different components of lung cancer associated with cystic airspace in patients treated with neoadjuvant chemotherapy

Scientific Reports ◽

10.1038/s41598-021-02897-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Peipei Dou ◽

Yankai Meng ◽

Hengliang Zhao ◽

Shuai Zhang ◽

Zhongxiao Liu ◽

...

Keyword(s):

Lung Cancer ◽

Neoadjuvant Chemotherapy ◽

Correlation Coefficient ◽

Computerized Tomography ◽

Significant Variation ◽

Volume Measurements ◽

Serial Ct ◽

First Time ◽

Area And Volume

AbstractThe aim of this study was to observe changes in different components (solid, cystic airspace, or entire tumor) in lung cancer associated with cystic airspace following treatment with neoadjuvant chemotherapy (NC), using computerized tomography (CT). We analyzed serial (baseline, first-time follow-up, and last-time follow-up) clinical data and CT imaging in six patients treated with NC. The diameters, areas, and volumes of different tumor components (solid, cystic airspace, and entire tumor) were measured. Delta (Δ) was used to represent changes in these parameters between two examinations: Δ1(%) represents the change from baseline to first follow-up after NC, and Δ2(%) represents the change from baseline to last follow-up after NC. We used the intra-group correlation coefficient (ICC) to test for consistency between parameters as measured by two radiologists. The diameter of solid components in all lesions showed a trend of continuous reduction compared with baseline (Δ1 ranged from − 8.3 to − 46.0%, Δ2 from − 30.8 to − 69.2%). For cystic airspace and entire tumors, different lesions showed different trends over the course of treatment. For diameter, area, and volume, Δ1 of changes in the solid component ranged from − 8.3 to − 46.9%, − 19.4 to − 70.8%, and − 19.1 to − 94.7%, respectively; Δ2 ranged from − 30.8 to − 69.2%, − 50.8 to − 92.1%, and − 32.7 to − 99.8% in diameter, area, and volume, respectively. Results were inconsistent between different components of lung cancer associated with cystic airspace that was treated with NC, but the diameter, area, and volume of solid components were continuously reduced during treatment. Furthermore, area and volume measurements showed more-significant variation than diameter measurements.

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Real-World Comparison of Human and Software Image Assessment in Acute Ischemic Stroke Patients’ Qualification for Reperfusion Treatment

Journal of Clinical Medicine ◽

10.3390/jcm9113383 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3383

Author(s):

Bartlomiej Lasocha ◽

Roman Pulyk ◽

Pawel Brzegowy ◽

Pawel Latacz ◽

Agnieszka Slowik ◽

...

Keyword(s):

Real World ◽

Ct Perfusion ◽

Reperfusion Therapy ◽

Computer Algorithms ◽

Stroke Patients ◽

Volume Measurements ◽

Manual Methods ◽

Rapid Processing ◽

Image Assessment

Our aim was to compare human and computer accuracy in reading medical images of acute stroke patients. We analyzed data of patients who underwent assessment of Alberta Stroke Program Early CT Score (ASPECTS) and CT Perfusion (CTP) via Rapid Processing of Perfusion and Diffusion (RAPID) software RAPID ASPECTS, and RAPID CTP), compared to radiologist reports and manual measurements. We compared volumes calculated by RAPID CTP software with those selected by scanner-equipped software (GE). For reference, follow-up images were manually assessed in accordance with the Alberta Stroke Program Early CT Score (ASPECTS) territories retrospectively. Although exact ASPECTS score agreement between the automatic and manual methods, and between each method and follow-up, was poor, crossing of the threshold for reperfusion therapy was characterized by an 80% match. CT perfusion analyses yielded only slight agreement (kappa = 0.193) in the qualification of patients for therapy. Either automatic or manual scoring methods of non-contrast images imply similar clinical decisions in real-world circumstances. However, volume measurements performed by fully automatic and manually assisted systems are not comparable. Thresholds devised and validated for computer algorithms are not compatible with measurements performed manually using other software and should not be applied to setups other than those with which they were developed.

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3D volume rendered Computed Tomography application for follow up fracture healing and volume measurements pre and post SRF

Journal of Trauma and Acute Care Surgery ◽

10.1097/ta.0000000000003383 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Don Campbell ◽

Nicholas Arnold ◽

Elizabeth Wake ◽

John Grieve ◽

Sylvio Provenzano ◽

...

Keyword(s):

Computed Tomography ◽

Fracture Healing ◽

Volume Measurements ◽

3D Volume

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The physiological basis and clinical significance of lung volume measurements

Multidisciplinary Respiratory Medicine ◽

10.4081/mrm.2017.220 ◽

2019 ◽

Vol 12 ◽

Author(s):

Mohamed Faisal Lutfi

Keyword(s):

Clinical Significance ◽

Lung Volume ◽

Lung Diseases ◽

Vital Capacity ◽

Air Flow ◽

Lung Volume Measurements ◽

Physiological Basis ◽

Lung Volumes ◽

Volume Measurements

From a physiological standpoint, the lung volumes are either dynamic or static. Both subclasses are measured at different degrees of inspiration or expiration; however, dynamic lung volumes are characteristically dependent on the rate of air flow. The static lung volumes/capacities are further subdivided into four standard volumes (tidal, inspiratory reserve, expiratory reserve, and residual volumes) and four standard capacities (inspiratory, functional residual, vital and total lung capacities). The dynamic lung volumes are mostly derived from vital capacity. While dynamic lung volumes are essential for diagnosis and follow up of obstructive lung diseases, static lung volumes are equally important for evaluation of obstructive as well as restrictive ventilatory defects. This review intends to update the reader with the physiological basis, clinical significance and interpretative approaches of the standard static lung volumes and capacities.

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METHODS FOR QUANTIFYING BREAST CANCER-RELATED LYMPHEDEMA IN PATIENTS UNDERGOING A CONTRALATERAL PROPHYLACTIC MASTECTOMY

Lymphology ◽

10.2458/lymph.4785 ◽

2022 ◽

Vol 54 (3) ◽

Author(s):

S.A. Roberts ◽

C.L. Brunelle ◽

T.C. Gillespie ◽

A.M. Shui ◽

K.M. Daniell ◽

...

Keyword(s):

Breast Cancer ◽

Prophylactic Mastectomy ◽

Significant Proportion ◽

Contralateral Prophylactic Mastectomy ◽

Relative Volume ◽

Significant Difference ◽

Bilateral Surgery ◽

Volume Measurements ◽

Breast Cancer Related Lymphedema

Patients treated for breast cancer are at risk of developing breast cancer-related lymphedema (BCRL). A significant proportion of patients treated for breast cancer are opting to undergo a contralateral prophylactic mastectomy (CPM). Currently, it remains unclear as to whether the relative volume change (RVC) equation may be used as an alternative to the weight adjusted change (WAC) equation to quantify BCRL in patients who undergo CPM. In order to simplify BCRL screening, our cohort of patients who underwent a CPM (n=310) was matched by BMI to a subset of patients who underwent unilateral breast surgery (n=310). Arm volume measurements were obtained via an optoelectronic perometer preoperatively, postoperatively, and in the follow-up setting every 6-12 months. The correlation of ipsilateral RVC and WAC values for those who underwent bilateral surgery was calculated (r=0.60). Contralateral WAC values for patients in both cohorts were compared, and there was no significant difference between the two distributions in variance (p=0.446). The RVC equation shows potential to be used to quantify ipsilateral postoperative arm volume changes for patients who undergo a CPM. However, a larger trial in which RVC and WAC values are prospectively assessed is needed.

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Gamma surgery for vestibular schwannoma

Journal of Neurosurgery ◽

10.3171/jns.2000.92.5.0745 ◽

2000 ◽

Vol 92 (5) ◽

pp. 745-759 ◽

Cited By ~ 186

Author(s):

Dheerendra Prasad ◽

Melita Steiner ◽

Ladislau Steiner

Keyword(s):

Vestibular Schwannoma ◽

Computer Software ◽

Primary Treatment ◽

Facial Paresis ◽

Content Type ◽

Primary Treatment Modality ◽

Case Surgery ◽

Volume Measurements ◽

Fine Print

Object. The goal of this study was to assess the results of gamma surgery (GS) for vestibular schwannoma (VS) in 200 cases treated over the last 10 years and to review the role of this neurosurgical procedure in the management of VS.Methods. Follow-up reviews ranging from 1 to 10 years were available in 153 of these patients. Follow-up images in these cases were analyzed using computer software that we developed to obtain volume measurements for the tumors, and the clinical condition of the patients was assessed using questionnaires.Gamma surgery was the primary treatment modality in 96 cases and followed microsurgery in 57 cases. Tumors ranged in volume from 0.02 to 18.3 cm3. In the group in which GS was the primary treatment, a decrease in volume was observed in 78 cases (81%), no change in 12 (12%), and an increase in volume in six cases (6%). The decrease was more than 75% in seven cases. In the group treated following microsurgery, a decrease in volume was observed in 37 cases (65%), no change in 14 (25%), and an increase in volume in six (11%). The decrease was more than 75% in eight cases. Five patients experienced trigeminal dysfunction; in three cases this was transient and in the other two it was persistent, although there has been improvement. Three patients had facial paresis (in one case this was transient, lasting 6 weeks; in one case there was 80% recovery at 18 months posttreatment; and in one case surgery was performed after the onset of facial paresis for presumed increase in tumor size). Over a 6-year period, hearing deteriorated in 60% of the patients. Three patients showed an improvement in hearing. No hearing deterioration was observed during the first 2 years of follow-up review.Conclusions. Gamma surgery should be used to treat postoperative residual tumors as well as tumors in patients with medical conditions that preclude surgery. Microsurgery should be performed whenever a surgeon is confident of extirpating the tumor with a risk—benefit ratio superior to that presented in this study.

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A One-Year Radiographic Healing Assessment after Endodontic Microsurgery Using Cone-Beam Computed Tomographic Scans

Journal of Clinical Medicine ◽

10.3390/jcm9113714 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3714

Author(s):

Sumi Kang ◽

Se-Won Ha ◽

Ukseong Kim ◽

Sunil Kim ◽

Euiseong Kim

Keyword(s):

Complete Healing ◽

Cone Beam ◽

Lesion Volume ◽

Computed Tomographic ◽

Endodontic Microsurgery ◽

Volume Measurements ◽

One Year ◽

The One ◽

Healing Assessment

This study aimed to evaluate one-year radiographic healing after endodontic microsurgery using CBCT with modified PENN 3D criteria and to compare the outcome with results evaluated using Molven’s criteria. A total of 107 teeth from 96 patients were evaluated one year after endodontic microsurgery by using CBCT scans with modified PENN 3D criteria and periapical radiographs with Molven’s criteria. Both preoperative and postoperative lesion volumes were calculated using ITK-SNAP (free software). Radiographic healing assessment using periapical radiographs and CBCT images, and preoperative and postoperative lesion volume measurements were performed independently by two examiners. The assessment using Molven’s criteria resulted in 75 complete healings, 18 incomplete healings, eight uncertain healings, and six unsatisfactory healings. Based on modified PENN 3D criteria, 64 teeth were categorized as complete healing, 29 teeth as limited healing, six teeth as uncertain healing, and eight teeth as unsatisfactory healing. With the one-year follow-up, CBCT scans showed a lower healing tendency than did periapical radiography. The volumes of apical radiolucency after the surgery were reduced by 77.7% on average at one-year follow up.

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