scholarly journals Ambient PM2.5 Exposure and Mortality Due to Lung Cancer and Cardiopulmonary Diseases in Polish Cities

2017 ◽  
pp. 9-17 ◽  
Author(s):  
Artur J. Badyda ◽  
James Grellier ◽  
Piotr Dąbrowiecki
Keyword(s):  
Lung Cancer ◽  
Pm2.5 Exposure

scholarly journals The Analysis in the Burden of Lung Cancer Attributable to PM2.5 Exposure in China

2020 ◽  
Author(s):  
xiaomei wu ◽  
Bo Zhu ◽  
Jin Zhou ◽  
Yifei Bi ◽  
Shuang Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Ambient Air ◽  
Downward Trend ◽  
Household Air Pollution ◽  
Ambient Air Pollution ◽  
Age Group ◽  
Upward Trend ◽  
Cancer Burden ◽  
Pm2.5 Exposure

Abstract Objective Air pollution is the major contributor of lung cancer mortality, we want to analyze the long-term trends and the differences in lung cancer burden attributable to PM2.5 exposure between ambient air pollution and household air pollution.Methods The indicators (mortality rate, disability-adjusted life years rate, years lived with disability rate, and years of life lost rate) of lung cancer burden were obtained from GBD 2017. The joinpoint regression analysis was used to assess the magnitude and direction of trends from 1990 to 2017, and the age-period-cohort method was used to analyze the temporal trends of the indicators of lung cancer by age, period, and cohort.Results The age-standardized indicators showed an upward trend in ambient PM2.5 exposure (APE) and a downward trend in household PM2.5 exposure (HPE). The overall net drifts per year were above zero for APE and below zero for HPE, and the local drift values in APE and HPE increased by age groups. For the longitudinal age curves, the indicators of lung cancer burden for younger in APE or HPE were in a low level, and significantly increased from 45-49 age group to 90-94 age group. For the period RRs, the indicators of lung cancer burden in APE increased from 1990 to 2017, but decreased in HPE from 1990 to 2017. For the cohort RRs, the indicators of lung cancer burden in APE was on the upward trend before 1965, and fluctuated after from 1970 to 1990. The indicators of lung cancer burden in HPE was on the downward trend.Conclusions For lung cancer attributable to air pollution, China had changed from household air pollution to ambient air pollution. PM2.5 exposure had more harmful in male and older people. Ambient air pollution should be emphasized, China should strengthen implementation of effective public policies and other interventions.

scholarly journals Ambient PM2.5 Exposure and Mortality Due to Lung Cancer and Cardiopulmonary Diseases in Polish Cities

2016 ◽  
Author(s):  
Artur J. Badyda ◽  
James Grellier ◽  
Piotr Dąbrowiecki
Keyword(s):  
Lung Cancer ◽  
Pm2.5 Exposure

scholarly journals Activated macrophages are crucial during acute PM2.5 exposure‑induced angiogenesis in lung cancer

2019 ◽  
Author(s):  
Ruyi Li ◽  
Liuqing Yang ◽  
Nan Jiang ◽  
Feiyun Wang ◽  
Pei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Activated Macrophages ◽  
Pm2.5 Exposure

scholarly journals Ambient Cumulative PM2.5 Exposure and the Risk of Lung Cancer Incidence and Mortality: A Retrospective Cohort Study

2021 ◽  
Vol 18 (23) ◽  
pp. 12400
Author(s):  
Hung-Ling Huang ◽  
Yung-Hsin Chuang ◽  
Tzu-Hsuan Lin ◽  
Changqing Lin ◽  
Yen-Hsu Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Smoking Status ◽  
Cox Proportional Hazards ◽  
Dietary Habit ◽  
Daily Consumption ◽  
Incidence And Mortality ◽  
Pm2.5 Exposure ◽  
Never Smokers

Smoking, sex, air pollution, lifestyle, and diet may act independently or in concert with each other to contribute to the different outcomes of lung cancer (LC). This study aims to explore their associations with the carcinogenesis of LC, which will be useful for formulating further preventive strategies. This retrospective, longitudinal follow-up cohort study was carried out by connecting to the MJ Health Database, Taiwan Cancer Registry database, and Taiwan cause of death database from 2000 to 2015. The studied subjects were persons attending the health check-ups, distributed throughout the main island of Taiwan. Cox proportional hazards regression models were used to investigate the risk factors associated with LC development and mortality after stratifying by smoking status, with a special emphasis on ambient two-year average PM2.5 exposure, using a satellite-based spatiotemporal model at a resolution of 1 km2, and on dietary habit including consumption of fruits and vegetables. After a median follow-up of 12.3 years, 736 people developed LC, and 401 people died of LC-related causes. For never smokers, the risk of developing LC (aHR: 1.32, 95%CI: 1.12–1.56) and dying from LC-related causes (aHR: 1.28, 95%CI: 1.01–1.63) rises significantly with every 10 μg/m3 increment of PM2.5 exposure, but not for ever smokers. Daily consumption of more than two servings of vegetables and fruits is associated with lowering LC risk in ever smokers (aHR: 0.68, 95%CI: 0.47–0.97), and preventing PM2.5 exposure is associated with lowering LC risk for never smokers.

scholarly journals The effects for PM2.5 exposure on non-small-cell lung cancer induced motility and proliferation

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Biao Yang ◽  
Dongmei Chen ◽  
Hui Zhao ◽  
Chunling Xiao
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Pm2.5 Exposure

PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells

2017 ◽  
Vol 1861 (2) ◽  
pp. 112-125 ◽  
Author(s):  
Xiaobei Deng ◽  
Nannan Feng ◽  
Min Zheng ◽  
Xiaofei Ye ◽  
Hongyan Lin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Migration And Invasion ◽  
Pm2.5 Exposure

scholarly journals Long-Term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults

2017 ◽  
Vol 186 (8) ◽  
pp. 961-969 ◽  
Author(s):  
Vivian C Pun ◽  
Fatemeh Kazemiparkouhi ◽  
Justin Manjourides ◽  
Helen H Suh
Keyword(s):  
Lung Cancer ◽  
Particulate Matter ◽  
Confidence Interval ◽  
Cancer Mortality ◽  
Moving Average ◽  
Lung Cancer Mortality ◽  
Pm2.5 Exposure ◽  
Risk Ratios ◽  
Cancer Mortality Risk

Abstract The impact of chronic exposure to fine particulate matter (particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5)) on respiratory disease and lung cancer mortality is poorly understood. In a cohort of 18.9 million Medicare beneficiaries (4.2 million deaths) living across the conterminous United States between 2000 and 2008, we examined the association between chronic PM2.5 exposure and cause-specific mortality. We evaluated confounding through adjustment for neighborhood behavioral covariates and decomposition of PM2.5 into 2 spatiotemporal scales. We found significantly positive associations of 12-month moving average PM2.5 exposures (per 10-μg/m3 increase) with respiratory, chronic obstructive pulmonary disease, and pneumonia mortality, with risk ratios ranging from 1.10 to 1.24. We also found significant PM2.5-associated elevated risks for cardiovascular and lung cancer mortality. Risk ratios generally increased with longer moving averages; for example, an elevation in 60-month moving average PM2.5 exposures was linked to 1.33 times the lung cancer mortality risk (95% confidence interval: 1.24, 1.40), as compared with 1.13 (95% confidence interval: 1.11, 1.15) for 12-month moving average exposures. Observed associations were robust in multivariable models, although evidence of unmeasured confounding remained. In this large cohort of US elderly, we provide important new evidence that long-term PM2.5 exposure is significantly related to increased mortality from respiratory disease, lung cancer, and cardiovascular disease.

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