Do Gene-by-Environment Interactions Offer Potential Intervention Strategies in Anxiety Disorders?

2017 ◽  
pp. 147-155 ◽  
Author(s):  
Neal Ryan
Keyword(s):  
Anxiety Disorders ◽  
Intervention Strategies ◽  
Potential Intervention ◽  
Gene By Environment Interactions

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

2019 ◽  
Author(s):  
Juyoen Hur ◽  
Melissa D. Stockbridge ◽  
Andrew S. Fox ◽  
Alexander J. Shackman
Keyword(s):  
Risk Factor ◽  
Anxiety Disorders ◽  
Executive Control ◽  
Intervention Strategies ◽  
Attentional Biases ◽  
Translational Neuroscience ◽  
Adult Personality ◽  
Fundamental Dimension ◽  
To Come ◽  
Underlying Mechanisms

When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.

Concluding remarks: variation and polymorphism in parasite phenotype – implications for the selection of potential intervention strategies

Parasitology ◽  
1989 ◽  
Vol 99 (S1) ◽  
pp. S147-S151
Author(s):  
R. E. Sinden
Keyword(s):  
Drug Development ◽  
Molecular Taxonomy ◽  
Intervention Strategies ◽  
Potential Intervention ◽  
Potential Efficacy ◽  
Host Parasite ◽  
Parasite Populations ◽  
Selection Of

Work reported at this meeting has described the exploitation of variation in parasite phenotype in disciplines ranging from molecular taxonomy and drug development, through the understanding of host-parasite interaction, to the evolution of parasite populations and determining the potential efficacy of vaccine programmes.

Human-Centred Methods in Information Systems

2011 ◽  
pp. 20-30 ◽  
Author(s):  
Steve Clarke ◽  
Brian Lehaney
Keyword(s):  
Information Systems ◽  
Intervention Strategy ◽  
Intervention Strategies ◽  
Potential Intervention ◽  
The Core ◽  
Boundary Setting ◽  
The Future

This paper is about determining the context and scope of an information systems study and choosing an intervention strategy based on the findings. At the core of this is a process of boundary setting, for which an approach which enables boundaries to be determined through critical participant analysis is recommended and described. Alternative potential intervention strategies are then discussed, and a description of how the choice of strategy was informed within a recent intervention is given. The paper concludes with a discussion of the findings, and a summary and critique, both theoretical and practical, of the approaches available to enhance such studies in the future.

The Third Month

2019 ◽  
pp. 167-180
Author(s):  
Vanessa LoBue
Keyword(s):  
Motor Skills ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Intervention Strategies ◽  
Sudden Infant ◽  
Potential Intervention ◽  
The Third ◽  
The Common

This chapter describes the development of the infant in the third month of life. After being warned by her pediatrician that her son has a flat head from sleeping on his back, the author discusses the common newborn issues of plagiocephaly and torticollis, how these diagnoses became popular, sudden infant death syndrome (SIDS), and how back sleeping might slow the development of motor milestones. She goes on to describe the development of infants’ motor skills like sitting, crawling, and walking, and the factors (including back sleeping) that might affect the timing of motor milestones. She concludes with a discussion of potential intervention strategies for babies with plagiocephaly.

Neuronal circuits of fear memory and fear extinction

e-Neuroforum ◽  
2013 ◽  
Vol 19 (3) ◽  
Author(s):  
C.T. Wotjak ◽  
H.-C. Pape
Keyword(s):  
Anxiety Disorders ◽  
Molecular Mechanisms ◽  
Fear Extinction ◽  
Intervention Strategies ◽  
Laboratory Animals ◽  
Mammalian Brain ◽  
Synaptic Circuits ◽  
Fear And Anxiety ◽  
High Degree ◽  
Synaptic Circuitry

AbstractThe paradigm“eat or be eaten” has proven to be a critical guiding element during the evolution of both humans and animals. This helps to explain the fact that the ability to de­tect danger or a threat has been highly con­served throughout evolution and thus exhib­its a high degree of homology between spe­cies. Studies in laboratory animals thereby enable the identification of key neurochem­ical, cellular and molecular mechanisms un­derlying fear and anxiety, and important­ly, permit conclusions to be drawn regard­ing the situation in humans. This, in turn, pro­vides a highly valuable basis for further im­provements in prognosis, diagnosis, preven­tion and therapy of anxiety disorders. The present article focuses on one aspect cen­tral to translational anxiety research: the neu­ronal substrates and circuits of fear memo­ry and fear extinction. Following a brief intro­duction into the principles of fear condition­ing, the synaptic circuits that underlie the ac­quisition and extinction of fear memories in the mammalian brain will be described. His­torically established principles will be system­atically compared with novel findings on the detailed synaptic circuitry of the fear matrix. Knowledge of the neuronal substrates and circuitry will significantly improve our under­standing of pathologically transformed states of fear and anxiety and thereby help to derive novel intervention strategies for the treat­ment of anxiety disorders.

scholarly journals Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Engineering ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 415-423 ◽  
Author(s):  
Wanqiang Wu ◽  
Qingmin Kong ◽  
Peijun Tian ◽  
Qixiao Zhai ◽  
Gang Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Neurological Disorders ◽  
Intervention Strategies ◽  
Potential Intervention ◽  
Gut Microbiota Dysbiosis
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