Do Gene-by-Environment Interactions Offer Potential Intervention Strategies in Anxiety Disorders?

When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.

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Exploring Potential Intervention Strategies to Reduce Unsafe Youth Migration in Ethiopia: a Mixed Methods Study

Journal of International Migration and Integration / Revue de l integration et de la migration internationale ◽

10.1007/s12134-021-00803-7 ◽

2021 ◽

Author(s):

Kassahun Habtamu ◽

Abebaw Minaye ◽

Fantahun Admas ◽

Messay Gebremariam Kotecho ◽

Abera Tibebu ◽

...

Keyword(s):

Mixed Methods ◽

Intervention Strategies ◽

Mixed Methods Study ◽

Potential Intervention ◽

Youth Migration

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Concluding remarks: variation and polymorphism in parasite phenotype – implications for the selection of potential intervention strategies

Parasitology ◽

10.1017/s0031182000083475 ◽

1989 ◽

Vol 99 (S1) ◽

pp. S147-S151

Author(s):

R. E. Sinden

Keyword(s):

Drug Development ◽

Molecular Taxonomy ◽

Intervention Strategies ◽

Potential Intervention ◽

Potential Efficacy ◽

Host Parasite ◽

Parasite Populations ◽

Selection Of

Work reported at this meeting has described the exploitation of variation in parasite phenotype in disciplines ranging from molecular taxonomy and drug development, through the understanding of host-parasite interaction, to the evolution of parasite populations and determining the potential efficacy of vaccine programmes.

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Human-Centred Methods in Information Systems

Human Factors in Information Systems ◽

10.4018/978-1-931777-10-0.ch002 ◽

2011 ◽

pp. 20-30 ◽

Cited By ~ 2

Author(s):

Steve Clarke ◽

Brian Lehaney

Keyword(s):

Information Systems ◽

Intervention Strategy ◽

Intervention Strategies ◽

Potential Intervention ◽

The Core ◽

Boundary Setting ◽

The Future

This paper is about determining the context and scope of an information systems study and choosing an intervention strategy based on the findings. At the core of this is a process of boundary setting, for which an approach which enables boundaries to be determined through critical participant analysis is recommended and described. Alternative potential intervention strategies are then discussed, and a description of how the choice of strategy was informed within a recent intervention is given. The paper concludes with a discussion of the findings, and a summary and critique, both theoretical and practical, of the approaches available to enhance such studies in the future.

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The Third Month

9 Months In, 9 Months Out ◽

10.1093/oso/9780190863388.003.0014 ◽

2019 ◽

pp. 167-180

Author(s):

Vanessa LoBue

Keyword(s):

Motor Skills ◽

Sudden Infant Death Syndrome ◽

Infant Death ◽

Sudden Infant Death ◽

Intervention Strategies ◽

Sudden Infant ◽

Potential Intervention ◽

The Third ◽

The Common

This chapter describes the development of the infant in the third month of life. After being warned by her pediatrician that her son has a flat head from sleeping on his back, the author discusses the common newborn issues of plagiocephaly and torticollis, how these diagnoses became popular, sudden infant death syndrome (SIDS), and how back sleeping might slow the development of motor milestones. She goes on to describe the development of infants’ motor skills like sitting, crawling, and walking, and the factors (including back sleeping) that might affect the timing of motor milestones. She concludes with a discussion of potential intervention strategies for babies with plagiocephaly.

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Neuronal circuits of fear memory and fear extinction

e-Neuroforum ◽

10.1007/s13295-013-0046-0 ◽

2013 ◽

Vol 19 (3) ◽

Cited By ~ 3

Author(s):

C.T. Wotjak ◽

H.-C. Pape

Keyword(s):

Anxiety Disorders ◽

Molecular Mechanisms ◽

Fear Extinction ◽

Intervention Strategies ◽

Laboratory Animals ◽

Mammalian Brain ◽

Synaptic Circuits ◽

Fear And Anxiety ◽

High Degree ◽

Synaptic Circuitry

AbstractThe paradigm“eat or be eaten” has proven to be a critical guiding element during the evolution of both humans and animals. This helps to explain the fact that the ability to detect danger or a threat has been highly conserved throughout evolution and thus exhibits a high degree of homology between species. Studies in laboratory animals thereby enable the identification of key neurochemical, cellular and molecular mechanisms underlying fear and anxiety, and importantly, permit conclusions to be drawn regarding the situation in humans. This, in turn, provides a highly valuable basis for further improvements in prognosis, diagnosis, prevention and therapy of anxiety disorders. The present article focuses on one aspect central to translational anxiety research: the neuronal substrates and circuits of fear memory and fear extinction. Following a brief introduction into the principles of fear conditioning, the synaptic circuits that underlie the acquisition and extinction of fear memories in the mammalian brain will be described. Historically established principles will be systematically compared with novel findings on the detailed synaptic circuitry of the fear matrix. Knowledge of the neuronal substrates and circuitry will significantly improve our understanding of pathologically transformed states of fear and anxiety and thereby help to derive novel intervention strategies for the treatment of anxiety disorders.

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