In Vitro Biotechnological Production and Pharmacological Studies of Antileukemic Alkaloids of Catharanthus roseus

2017 ◽  
pp. 17-34
Author(s):  
Hebert Jair Barrales-Cureño ◽  
Petra Andrade-Hoyos ◽  
Alfonso Luna-Cruz ◽  
Cesar Reyes-Reyes ◽  
Salvador Chávez-Salinas ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Biotechnological Production ◽  
Pharmacological Studies

Mechanism of the Antiplatelet Action of Dipyridamole in Whole Blood: Modulation of Adenosine Concentration and Activity

1986 ◽  
Vol 55 (01) ◽  
pp. 012-018 ◽  
Author(s):  
Paolo Gresele ◽  
Jef Arnout ◽  
Hans Deckmyn ◽  
Jos Vermylen
Keyword(s):  
Platelet Aggregation ◽  
Adenosine Receptor ◽  
Whole Blood ◽  
Blood Cells ◽  
Inhibitory Action ◽  
Phosphodiesterase Inhibitor ◽  
Inhibitory Effect ◽  
Adenosine Concentration ◽  
Pharmacological Studies

SummaryDipyridamole inhibits platelet aggregation in whole blood at lower concentrations than in plasma. The blood cells responsible for increased effectiveness in blood are the erythrocytes. Using the impedance aggregometer we have carried out a series of pharmacological studies in vitro to elucidate the mechanism of action of dipyridamole in whole blood. Adenosine deaminase, an enzyme breaking down adenosine, reverses the inhibitory action of dipyridamole. Two different adenosine receptor antagonists, 5’-deoxy-5’-methylthioadenosine and theophylline, also partially neutralize the activity of dipyridamole in blood. Enprofylline, a phosphodiesterase inhibitor with almost no adenosine receptor antagonistic properties, potentiates the inhibition of platelet aggregation by dipyridamole. An inhibitory effect similar to that of dipyridamole can be obtained combining a pure adenosine uptake inhibitor (RE 102 BS) with a pure phosphodiesterase inhibitor (MX-MB 82 or enprofylline). Mixing the blood during preincubation with dipyridamole increases the degree of inhibition. Lowering the haematocrit slightly reduces the effectiveness.Although we did not carry out direct measurements of adenosine levels, the results of our pharmacological studies clearly show that dipyridamole inhibits platelet aggregation in whole blood by blocking the reuptake of adenosine formed from precursors released by red blood cells following microtrauma. Its slight phosphodiesterase inhibitory action potentiates the effects of adenosine on platelets.

Efficacy of Catharanthus roseus Extract against Dengue Virus Type 2 Infection in Vitro

2020 ◽  
Vol 11 (2) ◽  
pp. 1583
Author(s):  
Noor Zarina Abd Wahab ◽  
NorefrinaShafinaz Md. Nor ◽  
Nazlina Ibrahim
Keyword(s):  
Dengue Virus ◽  
Virus Type ◽  
Catharanthus Roseus ◽  
Dengue Virus Type 2

Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin

2020 ◽  
Vol 21 (5) ◽  
pp. 499-508 ◽  
Author(s):  
Rémi Safi ◽  
Marwan El-Sabban ◽  
Fadia Najjar
Keyword(s):  
Wide Spectrum ◽  
Endemic Plant ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Sexual Impotence ◽  
Novel Applications ◽  
Anti Fungal ◽  
Sesquiterpene Ester

Ferula hermonis Boiss, is an endemic plant of Lebanon, locally known as “shilsh Elzallouh”. It has been extensively used in the traditional medicine as an aphrodisiac and for the treatment of sexual impotence. Crude extracts and isolated compounds of ferula hermonis contain phytoestrogenic substances having a wide spectrum of in vitro and in vivo pharmacological properties including anti-osteoporosis, anti-inflammatory, anti-microbial and anti-fungal, anti-cancer and as sexual activity enhancer. The aim of this mini-review is to highlight the traditional and novel applications of this plant’s extracts and its major sesquiterpene ester, ferutinin. The phytochemical constituents and the pharmacological uses of ferula hermonis crude extract and ferutinin specifically will be discussed.

scholarly journals The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 132
Author(s):  
Nilufar Z. Mamadalieva ◽  
Davlat Kh. Akramov ◽  
Ludger A. Wessjohann ◽  
Hidayat Hussain ◽  
Chunlin Long ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Herbal Medicines ◽  
Future Research ◽  
South Central ◽  
Pharmacological Studies ◽  
Central South

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

Recent trends in the biotechnological production of tocopherols using in vitro cultures

2021 ◽  
Author(s):  
Lorena Almagro ◽  
Ana Belén Sabater-Jara ◽  
Sarai Belchí-Navarro ◽  
María Ángeles Pedreño
Keyword(s):  
In Vitro Cultures ◽  
Biotechnological Production ◽  
Recent Trends

Nose-to-brain delivery of amisulpride-loaded lipid-based poloxamer-gellan gum nanoemulgel: In vitro and in vivo pharmacological studies

2021 ◽  
Vol 607 ◽  
pp. 121050
Author(s):  
Dnyandev Gadhave ◽  
Shrikant Tupe ◽  
Amol Tagalpallewar ◽  
Bapi Gorain ◽  
Hira Choudhury ◽  
...  
Keyword(s):  
Gellan Gum ◽  
Brain Delivery ◽  
Pharmacological Studies

Time-Course Studies on The Use of Secologanin by Catharanthus roseus Cells Cultured in vitro

1989 ◽  
Vol 134 (5) ◽  
pp. 608-612 ◽  
Author(s):  
F. Naudascher ◽  
P. Doireau ◽  
A. Guillot ◽  
C. Viel ◽  
M. Thiersault
Keyword(s):  
Catharanthus Roseus ◽  
Time Course ◽  
Cells Cultured

In vitro Production of Secondary Metabolites Using Elicitor in Catharanthus roseus: A Case Study

2013 ◽  
pp. 401-419 ◽  
Author(s):  
Zahid Hameed Siddiqui ◽  
Abdul Mujib ◽  
Mahmooduzzafar ◽  
Junaid Aslam ◽  
Khalid Rehman Hakeem ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Catharanthus Roseus ◽  
In Vitro Production ◽  
Vitro Production
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