Multiplex Immunoassay Profiling of Serum in Psychiatric Disorders

2017 ◽  
pp. 149-156 ◽  
Author(s):  
Laurie Stephen ◽  
Emanuel Schwarz ◽  
Paul C. Guest
Keyword(s):  
Psychiatric Disorders ◽  
Multiplex Immunoassay

scholarly journals Cerebrospinal fluid neuroplasticity-associated protein levels in patients with psychiatric disorders: a multiplex immunoassay study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shinsuke Hidese ◽  
Kotaro Hattori ◽  
Daimei Sasayama ◽  
Takuya Tsumagari ◽  
Tomoko Miyakawa ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Psychiatric Disorders ◽  
Multiplex Immunoassay ◽  
Protein Levels

scholarly journals Cerebrospinal Fluid Inflammatory Cytokine Levels in Patients With Major Psychiatric Disorders: A Multiplex Immunoassay Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Shinsuke Hidese ◽  
Kotaro Hattori ◽  
Daimei Sasayama ◽  
Takuya Tsumagari ◽  
Tomoko Miyakawa ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cerebrospinal Fluid ◽  
Psychiatric Disorders ◽  
Inflammatory Cytokines ◽  
Psychiatric Patients ◽  
Healthy Controls ◽  
Interferon Β ◽  
Multiplex Immunoassay ◽  
Cytokine Levels ◽  
Important Player

Aim: Accumulating evidence suggests that neural inflammation plays an important role in psychiatric disorders. We aimed to identify inflammatory cytokines involved in the pathophysiology of such disorders by quantifying them in cerebrospinal fluid (CSF) samples from a large sample of patients with major psychiatric disorders and healthy controls.Methods: The subjects included 94 patients with schizophrenia, 68 with bipolar disorder, 104 with major depressive disorder, and 118 healthy controls, matched for age, sex, and ethnicity (Japanese). Lumbar puncture was performed to collect these CSF samples. A multiplex immunoassay was then performed to measure CSF cytokine levels using magnetic on-bead antibody conjugation for 19 inflammatory cytokines.Results: CSF interferon-β level was significantly higher in total psychiatric patients than in healthy controls (corrected p = 0.000029). In diagnostic group comparisons, CSF interferon-β level was significantly higher in patients with schizophrenia, or bipolar disorder (corrected p = 0.000047 or 0.0034) than in healthy controls.Conclusion: We present novel evidence that CSF IFN-β level showed prominent statistical differences between psychiatric groups and healthy controls. This suggests IFN-β as the most important player among the 19 cytokines tested here in the inflammation-related pathophysiology of major psychiatric disorders.

What's in a model? Network models as tools instead of representations of what psychiatric disorders really are

2019 ◽  
Vol 42 ◽  
Author(s):  
Hanna M. van Loo ◽  
Jan-Willem Romeijn
Keyword(s):  
Psychiatric Disorders ◽  
Network Models ◽  
Model Network

AbstractNetwork models block reductionism about psychiatric disorders only if models are interpreted in a realist manner – that is, taken to represent “what psychiatric disorders really are.” A flexible and more instrumentalist view of models is needed to improve our understanding of the heterogeneity and multifactorial character of psychiatric disorders.

Psychiatric Disorders Inherited Separately From Atopy

2005 ◽  
Vol 36 (2) ◽  
pp. 63
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Psychiatric Disorders

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

Sati

Crisis ◽  
2005 ◽  
Vol 26 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Dinesh Bhugra
Keyword(s):  
Mental Illness ◽  
Psychiatric Disorders ◽  
Indian Subcontinent ◽  
Cultural Factors ◽  
Role Expectations ◽  
Prevention Strategies ◽  
Social Causation ◽  
Gender Role Expectations ◽  
Good Wife ◽  
And Gender

Abstract. Sati as an act of ritual suicide has been reported from the Indian subcontinent, especially among the Hindus, for several centuries. Although legally proscribed, these acts occur even now in modern India. The principle behind such acts has been put forward as the principle of good wife. There is little evidence to suggest that women who commit this act suffer from a formal mental illness. Cultural factors and gender role expectations play a significant role in the act and its consequences. Using recent examples, this paper illustrates the cultural factors, which may be seen as contributing to the act of suicide. Other factors embedded in the act also emphasize that not all suicides have underlying psychiatric disorders and clinicians must take social causation into account while preparing any prevention strategies.

Review of Biological bases of psychiatric disorders.

1978 ◽  
Vol 23 (10) ◽  
pp. 777-777
Author(s):  
RICHARD F. THOMPSON
Keyword(s):  
Psychiatric Disorders
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