A Comparison of Machine Learning Approaches for Classifying Multiple Sclerosis Courses Using MRSI and Brain Segmentations

2017 ◽  
pp. 643-651 ◽  
Author(s):  
Adrian Ion-Mărgineanu ◽  
Gabriel Kocevar ◽  
Claudio Stamile ◽  
Diana M. Sima ◽  
Françoise Durand-Dubief ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
Learning Approaches

Analysis of defective pathways and drug repositioning in Multiple Sclerosis via machine learning approaches

2019 ◽  
Vol 115 ◽  
pp. 103492 ◽  
Author(s):  
Enrique J. deAndrés-Galiana ◽  
Guillermina Bea ◽  
Juan L. Fernández-Martínez ◽  
Leo N. Saligan
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
Drug Repositioning ◽  
Learning Approaches

scholarly journals Ensemble learning predicts multiple sclerosis disease course in the SUMMIT study

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Yijun Zhao ◽  
◽  
Tong Wang ◽  
Riley Bove ◽  
Bruce Cree ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
San Francisco ◽  
Ensemble Learning ◽  
Disease Onset ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Learning Approaches ◽  
Disease Course ◽  
Learning Techniques

AbstractThe rate of disability accumulation varies across multiple sclerosis (MS) patients. Machine learning techniques may offer more powerful means to predict disease course in MS patients. In our study, 724 patients from the Comprehensive Longitudinal Investigation in MS at Brigham and Women’s Hospital (CLIMB study) and 400 patients from the EPIC dataset, University of California, San Francisco, were included in the analysis. The primary outcome was an increase in Expanded Disability Status Scale (EDSS) ≥ 1.5 (worsening) or not (non-worsening) at up to 5 years after the baseline visit. Classification models were built using the CLIMB dataset with patients’ clinical and MRI longitudinal observations in first 2 years, and further validated using the EPIC dataset. We compared the performance of three popular machine learning algorithms (SVM, Logistic Regression, and Random Forest) and three ensemble learning approaches (XGBoost, LightGBM, and a Meta-learner L). A “threshold” was established to trade-off the performance between the two classes. Predictive features were identified and compared among different models. Machine learning models achieved 0.79 and 0.83 AUC scores for the CLIMB and EPIC datasets, respectively, shortly after disease onset. Ensemble learning methods were more effective and robust compared to standalone algorithms. Two ensemble models, XGBoost and LightGBM were superior to the other four models evaluated in our study. Of variables evaluated, EDSS, Pyramidal Function, and Ambulatory Index were the top common predictors in forecasting the MS disease course. Machine learning techniques, in particular ensemble methods offer increased accuracy for the prediction of MS disease course.

Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis

2018 ◽  
Vol 24 ◽  
pp. 135-141 ◽  
Author(s):  
Ellen M. Mowry ◽  
Anna K. Hedström ◽  
Milena A. Gianfrancesco ◽  
Xiaorong Shao ◽  
Catherine A. Schaefer ◽  
...  
Keyword(s):  
Machine Learning ◽  
Risk Factors ◽  
Multiple Sclerosis ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Learning Approaches

Differentiation of multiple sclerosis lesions and low-grade brain tumors on MRS data: machine learning approaches

2021 ◽  
Author(s):  
Ziya Ekşi ◽  
Muhammed Emin Özcan ◽  
Murat Çakıroğlu ◽  
Cemil Öz ◽  
Ayşe Aralaşmak
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
Brain Tumors ◽  
Low Grade ◽  
Learning Approaches

Multiple vehicles detection and tracking for intelligent transport systems using machine learning approaches

2019 ◽  
Vol 70 (3) ◽  
pp. 214-224
Author(s):  
Bui Ngoc Dung ◽  
Manh Dzung Lai ◽  
Tran Vu Hieu ◽  
Nguyen Binh T. H.
Keyword(s):  
Machine Learning ◽  
Gaussian Mixture ◽  
Research Field ◽  
Transport Systems ◽  
Learning Approaches ◽  
Subtraction Method ◽  
Intelligent Transport Systems ◽  
Intelligent Transport ◽  
Detection And Tracking ◽  
Multiple Vehicles

Video surveillance is emerging research field of intelligent transport systems. This paper presents some techniques which use machine learning and computer vision in vehicles detection and tracking. Firstly the machine learning approaches using Haar-like features and Ada-Boost algorithm for vehicle detection are presented. Secondly approaches to detect vehicles using the background subtraction method based on Gaussian Mixture Model and to track vehicles using optical flow and multiple Kalman filters were given. The method takes advantages of distinguish and tracking multiple vehicles individually. The experimental results demonstrate high accurately of the method.

Mol2vec: Unsupervised Machine Learning Approach with Chemical Intuition

2017 ◽  
Author(s):  
Sabrina Jaeger ◽  
Simone Fulle ◽  
Samo Turk
Keyword(s):  
Machine Learning ◽  
Language Processing ◽  
Supervised Machine Learning ◽  
Learning Approach ◽  
Learning Approaches ◽  
Unsupervised Machine Learning ◽  
Feature Representations ◽  
Machine Learning Approach ◽  
The Individual ◽  
Vector Representations

Inspired by natural language processing techniques we here introduce Mol2vec which is an unsupervised machine learning approach to learn vector representations of molecular substructures. Similarly, to the Word2vec models where vectors of closely related words are in close proximity in the vector space, Mol2vec learns vector representations of molecular substructures that are pointing in similar directions for chemically related substructures. Compounds can finally be encoded as vectors by summing up vectors of the individual substructures and, for instance, feed into supervised machine learning approaches to predict compound properties. The underlying substructure vector embeddings are obtained by training an unsupervised machine learning approach on a so-called corpus of compounds that consists of all available chemical matter. The resulting Mol2vec model is pre-trained once, yields dense vector representations and overcomes drawbacks of common compound feature representations such as sparseness and bit collisions. The prediction capabilities are demonstrated on several compound property and bioactivity data sets and compared with results obtained for Morgan fingerprints as reference compound representation. Mol2vec can be easily combined with ProtVec, which employs the same Word2vec concept on protein sequences, resulting in a proteochemometric approach that is alignment independent and can be thus also easily used for proteins with low sequence similarities.

DETECTION OF ANOMALY BASED APPLICATION LAYER DDoS ATTACKS USING MACHINE LEARNING APPROACHES

2016 ◽  
Vol 4 (2) ◽  
pp. 6
Author(s):  
VANI NIDHI M.S.P.S. ◽  
PRASAD K. MUNIVARA ◽  
◽  
Keyword(s):  
Machine Learning ◽  
Learning Approaches ◽  
Ddos Attacks ◽  
Application Layer

Predictors of remission from body dysmorphic disorder after internet-delivered cognitive behavior therapy: a machine learning approach

2019 ◽  
Author(s):  
Oskar Flygare ◽  
Jesper Enander ◽  
Erik Andersson ◽  
Brjánn Ljótsson ◽  
Volen Z Ivanov ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Random Forests ◽  
Clinical Utility ◽  
Body Dysmorphic Disorder ◽  
Prediction Models ◽  
Behavioral Therapy ◽  
Learning Approach ◽  
Learning Approaches ◽  
Machine Learning Approach

**Background:** Previous attempts to identify predictors of treatment outcomes in body dysmorphic disorder (BDD) have yielded inconsistent findings. One way to increase precision and clinical utility could be to use machine learning methods, which can incorporate multiple non-linear associations in prediction models. **Methods:** This study used a random forests machine learning approach to test if it is possible to reliably predict remission from BDD in a sample of 88 individuals that had received internet-delivered cognitive behavioral therapy for BDD. The random forest models were compared to traditional logistic regression analyses. **Results:** Random forests correctly identified 78% of participants as remitters or non-remitters at post-treatment. The accuracy of prediction was lower in subsequent follow-ups (68%, 66% and 61% correctly classified at 3-, 12- and 24-month follow-ups, respectively). Depressive symptoms, treatment credibility, working alliance, and initial severity of BDD were among the most important predictors at the beginning of treatment. By contrast, the logistic regression models did not identify consistent and strong predictors of remission from BDD. **Conclusions:** The results provide initial support for the clinical utility of machine learning approaches in the prediction of outcomes of patients with BDD. **Trial registration:** ClinicalTrials.gov ID: NCT02010619.

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