Ageism and Neuropsychological Tests

Previous studies have indicated a consistent profile of basic personality traits correlated with adult Attention Deficit Hyperactivity Disorder (ADHD) (e.g., Ranseen, Campbell, & Baer, 1998; Nigg et al., 2002). In particular, research has found that low scores of the Conscientiousness trait and high scores on Neuroticism have been correlated with ADHD symptomatology. However, to date there is limited information concerning the range of effect resulting from medication treatment for adult ADHD. During an 18 month period, 60 adults were diagnosed with ADHD based on strict, DSM-IV criteria at an outpatient clinic. This evaluation included a battery of neuropsychological tests and a measure of general personality (i.e., the NEO PI-R). Eleven of these participants returned to complete the battery a second time. The pre-post comparisons revealed significant changes following sustained stimulant treatment on both the neuropsychological and self-report measures. These individuals also displayed significant changes on two domains of the NEO PI-R. They showed a significant decrease on the domain of Neuroticism, indicating that now see themselves as less prone to experience negative emotional states such as anxiety and depression. Additionally, they also reported a significant increase on their scores on the domain of conscientiousness. This increase suggests that they see themselves as more organized and dependable.

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Identification and Temporal Characterization of Features Associated with the Conversion from Mild Cognitive Impairment to Alzheimer’s Disease

Current Alzheimer Research ◽

10.2174/1567205015666180202095616 ◽

2018 ◽

Vol 15 (8) ◽

pp. 751-763 ◽

Cited By ~ 5

Author(s):

Antonio Martinez-Torteya ◽

Hugo Gomez-Rueda ◽

Victor Trevino ◽

Joshua Farber ◽

Jose Tamez-Pena ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Neuropsychological Tests ◽

Quantitative Mri ◽

Rank Test ◽

Longitudinal Models ◽

Log Rank Test ◽

Medical Histories

Background: Diagnosing Alzheimer’s disease (AD) in its earliest stages is important for therapeutic and support planning. Similarly, being able to predict who will convert from mild cognitive impairment (MCI) to AD would have clinical implications. Objectives: The goals of this study were to identify features from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database associated with the conversion from MCI to AD, and to characterize the temporal evolution of that conversion. Methods: We screened the publically available ADNI longitudinal database for subjects with MCI who have developed AD (cases: n=305), and subjects with MCI who have remained stable (controls: n=250). Analyses included 1,827 features from laboratory assays (n=12), quantitative MRI scans (n=1,423), PET studies (n=136), medical histories (n=72), and neuropsychological tests (n=184). Statistical longitudinal models identified features with significant differences in longitudinal behavior between cases and matched controls. A multiple-comparison adjusted log-rank test identified the capacity of the significant predictive features to predict early conversion. Results: 411 features (22.5%) were found to be statistically different between cases and controls at the time of AD diagnosis; 385 features were statistically different at least 6 months prior to diagnosis, and 28 features distinguished early from late conversion, 20 of which were obtained from neuropsychological tests. In addition, 69 features (3.7%) had statistically significant changes prior to AD diagnosis. Conclusion: Our results characterized features associated with disease progression from MCI to AD, and, in addition, the log-rank test identified features which are associated with the risk of early conversion.

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Comparison of the Validity of Neuropsychological Tests in the Diagnosis of Mild Cognitive Impairment

International Journal of Neural Systems Engineering ◽

10.21742/ijnse.2018.2.1.01 ◽

2018 ◽

Vol 2 (1) ◽

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Neuropsychological Tests

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A Within-Sample Comparison of Two Innovative Neuropsychological Tests for Assessing ADHD

Brain Sciences ◽

10.3390/brainsci11010036 ◽

2020 ◽

Vol 11 (1) ◽

pp. 36

Author(s):

Anna Baader ◽

Behnaz Kiani ◽

Nathalie Brunkhorst-Kanaan ◽

Sarah Kittel-Schneider ◽

Andreas Reif ◽

...

Keyword(s):

Neuropsychological Tests ◽

Rating Scales ◽

Clinical Symptoms ◽

Clinical Sample ◽

Clinical Parameters ◽

Performance Tests ◽

Hyperactivity Disorder ◽

Continuous Performance Tests ◽

Interesting Correlation ◽

Clinical Measures

New innovative neuropsychological tests in attention deficit hyperactivity disorder ADHD have been proposed as objective measures for diagnosis and therapy. The current study aims to investigate two different commercial continuous performance tests (CPT) in a head-to-head comparison regarding their comparability and their link with clinical parameters. The CPTs were evaluated in a clinical sample of 29 adult patients presenting in an ADHD outpatient clinic. Correlational analyses were performed between neuropsychological data, clinical rating scales, and a personality-based measure. Though inattention was found to positively correlate between the two tests (r = 0.49, p = 0.01), no association with clinical measures and inattention was found for both tests. While hyperactivity did not correlate between both tests, current ADHD symptoms were positively associated with Nesplora Aquarium’s motor activity (r = 0.52 to 0.61, p < 0.05) and the Qb-Test’s hyperactivity (r = 0.52 to 0.71, p < 0.05). Conclusively, the overall comparability of the tests was limited and correlation with clinical parameters was low. While our study shows some interesting correlation between clinical symptoms and sub-scales of these tests, usage in clinical practice is not recommended.

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Study of the Interaction between Executive Function and Adaptive Behavior at School in Girls with Fragile X Syndrome

Genes ◽

10.3390/genes12081108 ◽

2021 ◽

Vol 12 (8) ◽

pp. 1108

Author(s):

Lorena Joga-Elvira ◽

Jennifer Martinez-Olmo ◽

María-Luisa Joga ◽

Carlos Jacas ◽

Ana Roche-Martínez ◽

...

Keyword(s):

Executive Function ◽

Executive Functions ◽

Fragile X Syndrome ◽

Adaptive Behavior ◽

Neuropsychological Tests ◽

Rating Scale ◽

Fragile X ◽

School Setting ◽

Control Group ◽

The Relationship

The aim of this research is to analyze the relationship between executive functions and adaptive behavior in girls with Fragile X syndrome (FXS) in the school setting. This study is part of a larger investigation conducted at the Hospital Parc Tauli in Sabadell. The sample consists of a total of 40 girls (26 with FXS and 14 control) aged 7–16 years, who were administered different neuropsychological tests (WISC-V, NEPSY-II, WCST, TOL) and questionnaires answered by teachers (ABAS-II, BRIEF 2, ADHD Rating Scale). The results show that there is a greater interaction between some areas of executive function (cognitive flexibility, auditory attention, and visual abstraction capacity) and certain areas of adaptive behavior (conceptual, practical, social, and total domains) in the FXS group than in the control group. These results suggest that an alteration in the executive functions was affecting the daily functioning of the girls with FXS to a greater extent.

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Latent Structure of a Brief Clinical Battery of Neuropsychological Tests Administered In-Home Via Telephone

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acaa111 ◽

2020 ◽

Author(s):

Anastasia Matchanova ◽

Michelle A Babicz ◽

Luis D Medina ◽

Samina Rahman ◽

Briana Johnson ◽

...

Keyword(s):

Executive Functions ◽

Factor Structure ◽

Neuropsychological Tests ◽

Factor Model ◽

Digit Span ◽

Neuropsychological Battery ◽

Memory And Attention ◽

Sociodemographic Correlates ◽

List Learning ◽

Trail Making

Abstract Objective To examine the factor structure and sociodemographic correlates of a battery of clinical neuropsychological tests administered in-home and via telephone. Method Participants included 280 healthy adults who completed a 35–40 min battery consisting of seven auditory-verbal neuropsychological tests (i.e., 10 variables) that included digit span, list learning and memory, prospective memory, verbal fluency, and oral trail making. Results After removing oral trail making part A, a three-factor model comprised of executive functions, memory and attention demonstrated the best fit to the data. Nevertheless, the shared variance between the nine remaining neuropsychological variables was also adequately explained by a single-factor model and a two-factor model comprised of executive functions and memory. Factor scores were variably associated with education, race/ethnicity, and IQ, but not with sex or age. Conclusions Findings provide preliminary support for the feasibility and factor structure and sociodemographic correlates of a brief telephone-based screening neuropsychological battery comprised mostly of commonly administered clinical measures. Future studies are needed to determine the test–retest reliability, sensitivity, and ecological relevance of this battery, as well as equivalency to in-person assessment.

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