Geographic Space in Museums: Considerations Towards a Spatio-Temporal Supported Exhibition

Author(s):  
Michaela Kinberger ◽  
Alexander Pucher
Author(s):  
Claudio E. C. Campelo ◽  
Brandon Bennett

This chapter discusses the issues and challenges arising when building a general spatio-temporal ontology for representing and reasoning of geographical processes as part of a desired universal semantic reference system of geographic space. It examines the foundations and formalisms upon which the development of such an ontological model of geographical processes can be based. The chapter begins by providing a background of essential concepts related to the representation of geographical processes. Then overviews of several approaches to representing spatio-temporal processes and how to associate them with geographic space are given. Following this, the chapter discusses several open issues on the topic and presents a set of desiderata for representing and reasoning about real-world dynamic geographical phenomena. This discussion covers aspects of space, time, object, event, state, and process as the essential concepts to represent geo-processes. It also covers aspects of spatial-temporal granularity and spatio-temporal aggregation, describing how they relate to geographical processes. Finally, this chapter also explores the phenomenon of vagueness and how it affects the representation and reasoning about geo-processes. The chapter concludes by indicating directions for future research and recapitulating its overall coverage.


2010 ◽  
Vol 16 (4) ◽  
pp. 603-612 ◽  
Author(s):  
Giedrė Beconytė ◽  
Audrius Kryžanauskas

Information communication technologies are widely used to support sustainable development. As both nature and society exist and develop in the geographic space, a good decision making can hardly be imagined without a prior thorough analysis of spatio‐temporal distribution and spatial correlation of diverse ecological, economical and social parameters. Wherever such geospatial relationships are concerned, the methods of geography as of a geographic information science are commonly applied, among which cartography is the most efficient information communication method. Different levels of representation of geographic information, such as databases, geographic information systems (GIS), maps, atlases and Spatial Data Infrastructures can be easily and conveniently used for different steps of planning. More than that, maps have a hidden potential to reveal unknown spatial patterns and trends and the process does not require any specific technological skills from the user. Therefore it is very important to include geographic/cartographic dimension into regional and national sustainable development strategies, so that spatial structures, diversities, similarities and geographic determination are always taken into account. To facilitate the process of geographic decision making, we develop a uniform model of description of geographic methods that could be used online and provide suggestions on which of the known methods could be efficiently applied. Santrauka Tvarioji plėtra nebūtų įmanoma be informacijos komunikavimo priemonių ir technologijų. Ir gamta, ir visuomenė egzistuoja ir vystosi erdvėje, tad neįmanoma įsivaizduoti tinkamu planavimo sprendimų, kurie nebūtų pagristi išankstine išsamia dalykinės srities erdvės ir laiko ryšių analize, neįvertintų erdvinių sąsajų tarp ekologinių, ekonominių ir socialinių parametrų. Visur, kur svarbus objektų išsidėstymas ir jų tarpusavio ryšiai geografinėje erdvėje ir laike, yra taikomi geografinės informacijos mokslo (šiuolaikines geografijos) metodai. Vienas efektyviausių yra kartografinis metodas, leidžiantis intuityviai pastebėti erdvinius ryšius. Galima nagrinėti skirtingus geografines informacijos organizavimo lygmenis, tokius kaip duomenų bazes, geografines informacijos (GIS) sistemos, žemėlapiai, atlasai bei erdvinių duomenų infrastruktūros. Visas šias sistemas galima patogiai ir nesunkiai naudoti įvairiuose planavimo etapuose. Be to, žemėlapiai turi paslėpta potencialą atskleisti iš anksto nežinomus erdvinius ryšius bei tendencijas. Šis procesas yra intuityvus ir nereikalauja iš naudotojo jokiu specialių technologijų žinių ar įgūdžiu. Todėl labai svarbu į nacionalines ir regionines plėtros strategijas įtraukti ir geografini/kartografini matmenį, atsižvelgti į erdvinio išsidėstymo struktūras, skirtumus, panašumas ir galimus geografinius apribojimus. Straipsnio autoriai pasiūlė ir šiuo metu Vilniaus universitete plėtoja universalų geografinių uždavinių aprašymu modelį, kuris padėtu geografines informacijos naudotojams be specialiu žinių pasirinkti tinkama sprendimų seką ir metodus.


2005 ◽  
Vol 41 ◽  
pp. 15-30 ◽  
Author(s):  
Helen C. Ardley ◽  
Philip A. Robinson

The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds). Post-translational modifications of the protein substrate, such as phosphorylation or hydroxylation, are often required prior to its selection. In this way, the precise spatio-temporal targeting and degradation of a given substrate can be achieved. The E3s are a large, diverse group of proteins, characterized by one of several defining motifs. These include a HECT (homologous to E6-associated protein C-terminus), RING (really interesting new gene) or U-box (a modified RING motif without the full complement of Zn2+-binding ligands) domain. Whereas HECT E3s have a direct role in catalysis during ubiquitination, RING and U-box E3s facilitate protein ubiquitination. These latter two E3 types act as adaptor-like molecules. They bring an E2 and a substrate into sufficiently close proximity to promote the substrate's ubiquitination. Although many RING-type E3s, such as MDM2 (murine double minute clone 2 oncoprotein) and c-Cbl, can apparently act alone, others are found as components of much larger multi-protein complexes, such as the anaphase-promoting complex. Taken together, these multifaceted properties and interactions enable E3s to provide a powerful, and specific, mechanism for protein clearance within all cells of eukaryotic organisms. The importance of E3s is highlighted by the number of normal cellular processes they regulate, and the number of diseases associated with their loss of function or inappropriate targeting.


2019 ◽  
Vol 47 (6) ◽  
pp. 1733-1747 ◽  
Author(s):  
Christina Klausen ◽  
Fabian Kaiser ◽  
Birthe Stüven ◽  
Jan N. Hansen ◽  
Dagmar Wachten

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.


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