Morphological Studies on Brain Structures of the NZB Mouse: An Animal Model for the Aging Human Brain?

1985 ◽  
pp. 355-365 ◽  
Author(s):  
K. Zilles
Keyword(s):  
Animal Model ◽  
Human Brain ◽  
Brain Structures ◽  
Morphological Studies

scholarly journals First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain

2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Eva Matt ◽  
Lisa Kaindl ◽  
Saskia Tenk ◽  
Anicca Egger ◽  
Teodora Kolarova ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Stimulation ◽  
Longitudinal Design ◽  
Brain Structures ◽  
Brain Network ◽  
Long Term Effects ◽  
Sensorimotor Network ◽  
Functional Brain Network ◽  
Pulse Stimulation

Abstract Background With the high spatial resolution and the potential to reach deep brain structures, ultrasound-based brain stimulation techniques offer new opportunities to non-invasively treat neurological and psychiatric disorders. However, little is known about long-term effects of ultrasound-based brain stimulation. Applying a longitudinal design, we comprehensively investigated neuromodulation induced by ultrasound brain stimulation to provide first sham-controlled evidence of long-term effects on the human brain and behavior. Methods Twelve healthy participants received three sham and three verum sessions with transcranial pulse stimulation (TPS) focused on the cortical somatosensory representation of the right hand. One week before and after the sham and verum TPS applications, comprehensive structural and functional resting state MRI investigations and behavioral tests targeting tactile spatial discrimination and sensorimotor dexterity were performed. Results Compared to sham, global efficiency significantly increased within the cortical sensorimotor network after verum TPS, indicating an upregulation of the stimulated functional brain network. Axial diffusivity in left sensorimotor areas decreased after verum TPS, demonstrating an improved axonal status in the stimulated area. Conclusions TPS increased the functional and structural coupling within the stimulated left primary somatosensory cortex and adjacent sensorimotor areas up to one week after the last stimulation. These findings suggest that TPS induces neuroplastic changes that go beyond the spatial and temporal stimulation settings encouraging further clinical applications.

scholarly journals Cellular resolution anatomical and molecular atlases for prenatal human brains

2021 ◽  
Author(s):  
Song-Lin Ding ◽  
Joshua J. Royall ◽  
Phil Lesnar ◽  
Benjamin A.C. Facer ◽  
Kimberly A. Smith ◽  
...  
Keyword(s):  
Human Brain ◽  
Hippocampal Formation ◽  
Marker Gene ◽  
Brain Structures ◽  
Marker Genes ◽  
Subcortical Structures ◽  
Cellular Resolution ◽  
Reliable Marker ◽  
Human Brains ◽  
Developmental Features

Increasing interest in studies of prenatal human brain development, particularly using new single-cell genomics and anatomical technologies to create cell atlases, creates a strong need for accurate and detailed anatomical reference atlases. In this study, we present two cellular-resolution digital anatomical atlases for prenatal human brain at post-conceptional weeks (PCW) 15 and 21. Both atlases were annotated on sequential Nissl-stained sections covering brain-wide structures on the basis of combined analysis of cytoarchitecture, acetylcholinesterase staining and an extensive marker gene expression dataset. This high information content dataset allowed reliable and accurate demarcation of developing cortical and subcortical structures and their subdivisions. Furthermore, using the anatomical atlases as a guide, spatial expression of 37 and 5 genes from the brains respectively at PCW 15 and 21 was annotated, illustrating reliable marker genes for many developing brain structures. Finally, the present study uncovered several novel developmental features, such as the lack of an outer subventricular zone in the hippocampal formation and entorhinal cortex, and the apparent extension of both cortical (excitatory) and subcortical (inhibitory) progenitors into the prenatal olfactory bulb. These comprehensive atlases provide useful tools for visualization, targeting, imaging and interpretation of brain structures of prenatal human brain, and for guiding and interpreting the next generation of cell census and connectome studies.

scholarly journals Volitional Control of Individual Neurons in the Human Brain

2020 ◽  
Author(s):  
Kramay Patel ◽  
Chaim N. Katz ◽  
Suneil K. Kalia ◽  
Milos R. Popovic ◽  
Taufik A. Valiante
Keyword(s):  
Human Brain ◽  
Firing Rate ◽  
Phase Locking ◽  
Brain Structures ◽  
Human Memory ◽  
Skill Learning ◽  
Oscillation Phase ◽  
Improved Performance ◽  
Beta Frequency ◽  
Interconnected Structure

AbstractCan the human brain, a complex interconnected structure of over 80 billion neurons learn to control itself at the most elemental scale – a single neuron. We directly linked the firing rate of a single (direct) neuron to the position of a box on a screen, which participants tried to control. Remarkably, all subjects upregulated the firing rate of the direct neuron in memory structures of their brain. Learning was accompanied by improved performance over trials, simultaneous decorrelation of the direct neuron to local neurons, and direct neuron to beta frequency oscillation phase-locking. Such previously unexplored neuroprosthetic skill learning within memory related brain structures, and associated beta frequency phase-locking implicates the ventral striatum. Our demonstration that humans can volitionally control neuronal activity in mnemonic structures, may provide new ways of probing the function and plasticity of human memory without exogenous stimulation.

Mind and Matter

Mind Shift ◽  
2021 ◽  
pp. 19-31
Author(s):  
John Parrington
Keyword(s):  
Human Brain ◽  
Rene Descartes ◽  
Brain Structures ◽  
Human Mind ◽  
Black Box ◽  
Human Consciousness ◽  
Common Thread ◽  
René Descartes

This chapter discusses different views on the basis of human consciousness. A major problem with much popular speculation about the biological roots of consciousness is that those who advocate a gene-based view of consciousness often appear to have little understanding of modern genetics, while speculation about how brain structures shape that consciousness often bear little resemblance to emerging knowledge about the complexity of an actual human brain. There is a common thread here, which is that idealised genes and brains have been substituted for real ones. Unfortunately, because of this tendency, it is not clear how much we have really advanced forwards from René Descartes and his belief that the human mind was an unknowable entity, or for that matter, the behaviourists with their view that the human mind could be treated as a black box. In contrast, to understand human consciousness, there is a need to understand real genes, real brains, and how these have evolved in humans compared to other species.

NONLINEAR DYNAMICS AND THE SYNTHESIS OF ZEBRA FINCH SONG

2012 ◽  
Vol 22 (10) ◽  
pp. 1250235 ◽  
Author(s):  
YONATAN SANZ PERL ◽  
EZEQUIEL M. ARNEODO ◽  
ANA AMADOR ◽  
GABRIEL B. MINDLIN
Keyword(s):  
Nonlinear Dynamics ◽  
Animal Model ◽  
Nervous System ◽  
Zebra Finch ◽  
Brain Structures ◽  
Complex Behavior ◽  
Acoustic Features ◽  
System A ◽  
Zebra Finch Song ◽  
Vocal Organ

Behavior emerges as the interaction between a nervous system, a peripheral biomechanical device and the environment. In birdsong production, this observation is particularly important: songbirds are an adequate animal model to unveil how brain structures reconfigure themselves during learning of a complex behavior as song. Therefore, it is important to understand which features of behavior are controlled by independent tuning of neurophysiological parameters, and which are constrained by the biomechanics of the peripheral vocal organ. In this work, we show that many of the acoustic features in the Zebra finch song are in fact conditioned by the biomechanics involved.

Multiple obstacles to gene therapy in the brain

1995 ◽  
Vol 18 (1) ◽  
pp. 67-68
Author(s):  
David Avram Sanders
Keyword(s):  
Gene Therapy ◽  
Animal Model ◽  
Gene Transfer ◽  
Human Brain ◽  
Viral Vector ◽  
Mode Of Delivery ◽  
The Brain ◽  
Multiple Obstacles

AbstractNeuwelt et al. have proposed gene-transfer experiments utilizing an animal model that offers many important advantages for investigating the feasibility of gene therapy in the human brain. A variety of tissues concerning the viral vector and mode of delivery of the corrective genes need to be resolved, however, before such therapy is scientifically supportable.

scholarly journals From Animal Model to Human Brain Networking: Dynamic Causal Modeling of Motivational Systems

2012 ◽  
Vol 32 (21) ◽  
pp. 7218-7224 ◽  
Author(s):  
T. Gonen ◽  
R. Admon ◽  
I. Podlipsky ◽  
T. Hendler
Keyword(s):  
Animal Model ◽  
Human Brain ◽  
Causal Modeling ◽  
Dynamic Causal Modeling ◽  
Motivational Systems

scholarly journals Antibodies to normal and Alzheimer human brain structures from non-immunised mice of various ages

FEBS Letters ◽  
1987 ◽  
Vol 217 (1) ◽  
pp. 62-64 ◽  
Author(s):  
James Simpson ◽  
Ian H. Milne ◽  
John O. Gardner ◽  
Celia M. Yates ◽  
Keith James ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Structures

scholarly journals Realistic modeling of ephaptic fields in the human brain

2019 ◽  
Author(s):  
Giulio Ruffini ◽  
Ricardo Salvador ◽  
Ehsan Tadayon ◽  
Roser Sanchez-Todo ◽  
Alvaro Pascual-Leone ◽  
...  
Keyword(s):  
Human Brain ◽  
Electric Fields ◽  
Neuronal Activity ◽  
Direct Interaction ◽  
Pyramidal Cells ◽  
Brain Structures ◽  
Relative Orientation ◽  
Transcranial Brain Stimulation ◽  
Potential Perturbation ◽  
Human Function

AbstractSeveral decades of research suggest that weak electric fields may influence neural processing, including those induced by neuronal activity and recently proposed as substrate for a potential new cellular communication system, i.e., ephaptic transmission. Here we aim to map ephaptic activity in the human brain and explore its trajectory during aging by characterizing the macroscopic electric field generated by cortical dipoles using realistic finite element modeling. We find that modeled endogenous field magnitudes are comparable to those in measurements of weak but functionally relevant endogenous fields and to those generated by noninvasive transcranial brain stimulation, therefore possibly able to modulate neuronal activity. Then, to evaluate the role of self-generated ephaptic fields in the human cortex, we adapt an interaction approximation that considers the relative orientation of neuron and field to derive the membrane potential perturbation in pyramidal cells. Building on this, we define a simplified metric (EMOD1) that weights dipole coupling as a function of distance and relative orientation between emitter and receiver and evaluate it in a sample of 401 realistic human brain models from subjects aged 16-83. Results reveal that ephaptic modulation follows gyrification patterns in the human brain, and significantly decreases with age, with higher involvement of sensorimotor regions and medial brain structures. By providing the means for fast and direct interaction between neurons, ephaptic modulation likely contributes to the complexity of human function for cognition and behavior, and its modification across the lifespan and in response to pathology.

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