5-Hydroxymethylfurfural (HMF) has emerged as a crucial bio-based chemical building block in the drive towards developing materials from renewable resources, due to its direct preparation from sugars and its readily diversifiable scaffold. A key obstacle in transitioning to bio-based plastic production lies in meeting the necessary industrial production efficiency, particularly in the cost-effective conversion of HMF to valuable intermediates. To address the challenge of developing scalable technology for oxidizing crude HMF to more valuable chemicals, we have integrated process and enzyme engineering to provide a galactose oxidase (GOase) variant with remarkably high activity toward HMF, improved O2 binding and excellent productivity (>1,000,000 TTN). The process concept presented here for GOase catalysed selective oxidation of HMF to 2,5-diformylfuran offers a productive and efficient platform for further development, thereby laying the groundwork for a biocatalytic route to scalable production of furan-based chemical building blocks from sustainable feedstocks.<br>
AbstractThe main objective of ISO/TC 261 is to standardise the processes of Additive Manufacturing, the process chains (Data, Materials, Processes, Hard- and Software, Applications), test procedures, quality parameters, supply agreements, environment, health and safety, fundamentals and vocabularies. The technical contents for those standards are developed in different Working Groups of ISO/TC 261. This section provides readers with news regarding standardisation efforts of ISO/TC 261.
Review on miniaturization, integration, and automation of laboratory processes within centrifugal microfluidic platforms. For efficient implementation of applications, building blocks are categorized into unit operations and process chains.
Interest in additive manufacturing has recently been spurred by the promise of multi-material printing and the ability to embed functionality and intelligence into objects. Here, we present an alternative to additive manufacturing, introducing an end-to-end workflow in which discrete building blocks are reversibly joined to produce assemblies called digital materials. We describe the design of the bulk-material building blocks and the devices that are assembled from them. Further, we detail the design and implementation of an automated assembler, which takes advantage of the digital material structure to restore positioning errors within a large tolerance. To generate assembly sequences, we use a novel CAD/CAM workflow for designing, simulating, and assembling digital materials. Finally, we evaluate the structures assembled using this process, showing that the joints perform well under varying conditions and that the assembled structures are functionally precise.
Additive manufacturing and in particular Selective Laser Melting (SLM) are manufacturing technologies that can become a game changer for the production of future high performance hot gas path parts. SLM radically changes the design process giving unprecedented freedom of design and enabling a step change in part performance. Benefits are manifold, such as reduced cooling air consumption through more efficient cooling schemes, reduced emissions through better mixing in the combustion process and reduced cost through integrated part design. GE is already making use of SLM for its gas turbine components based on sound experience for new part production and reconditioning.
The paper focuses on:
a) Generic advantages of rapid manufacturing and design considerations for hot gas path parts
b) Qualification of processes and additive manufacturing of engine ready parts
c) SLM material considerations and properties validation
d) Installation and validation in a heavy duty GT
Additive Manufacturing (AM) of hot gas path components differs significantly from known process chains. All elements of this novel manufacturing route had to be established and validated. This starts with the selection of the powder alloy used for the SLM production and the determination of essential static and cyclic material properties.
SLM specific design features and built-in functionality allow to simplify part assembly and to shortcut manufacturing steps. In addition, the post-SLM machining steps for engine ready parts will be described.
As SLM is a novel manufacturing route, complementary quality tools are required to ensure part integrity. Powerful nondestructive methods, like 3D scanning and X-ray computer tomography have been used for that purpose. GE’s engine validation of SLM made parts in a heavy duty GT was done with selected hot gas path components in a rainbow arrangement including turbine blades with SLM tip caps.
Although SLM has major differences to conventional manufacturing the various challenges from design to engine ready parts have been successfully mastered. This has been confirmed after the completion of the test campaign in 2015. All disassembled SLM components were found in excellent condition. Subsequent assessments of the SLM parts including metallurgical investigations have confirmed the good part condition.
Integration of Fiber-Reinforced Polymers in a Life Cycle Assessment of Injection Molding Process Chains with Additive Manufacturing
