Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

1996 ◽  
Keyword(s):  
Drug Delivery ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Advanced Biomaterials

Prototype of Microcapsule Including a Gas Bubble for Developing Shock Wave Drug Delivery Systems

2005 ◽  
Author(s):  
Masaaki Tamagawa ◽  
Ichiro Yamanoi
Keyword(s):  
Mechanical Properties ◽  
Shock Wave ◽  
Drug Delivery ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Gas Bubble ◽  
Nano Technology ◽  
System A

This paper describes the trial of making microcapsules including a bubble for shock wave drug delivery systems and evaluation of their mechanical properties. We have proposed drug delivery systems (DDS) using shock waves in order to apply micro/nano technology in the fields of biomedical engineering. In this system, a microcapsule including a gas bubble is flown in the blood vessel, and finally broken by shock induced microjet, then drug is reached to the affected part in the body as same as traditional DDS. In this paper, the mechanism for deformation and disintegration of capsules in our previous works is reviewed, and the trials of making special microcapsules are discussed. To determine Young’s modulus of capsule membrane mentioned above, the membrane is deformed by the aspiration device and the deformation is compared with computational result by FEM.

scholarly journals Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

2021 ◽  
Author(s):  
Gokhan Demirci ◽  
Malwina Niedzwiedz ◽  
Nina Kantor-Malujdy ◽  
Miroslawa El Fray
Keyword(s):  
Drug Delivery ◽  
Hybrid Systems ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Antibacterial Properties ◽  
Delivery Systems ◽  
Medical Applications ◽  
Polymer Hybrid ◽  
Current State ◽  
Advanced Biomaterials

Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

scholarly journals Chronology of Global Success: 20 Years of Prof Vallet-Regí Solving Questions

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2179
Author(s):  
Miguel Manzano
Keyword(s):  
Drug Delivery ◽  
Mesoporous Materials ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Research Team ◽  
Delivery Systems ◽  
Present Review ◽  
Potential Drug ◽  
The World ◽  
First Time

Twenty years ago, a group of bold scientists led by Prof Vallet-Regí suggested for the first time the use of mesoporous materials as potential drug delivery systems. Without knowing it; these pioneers unleashed the beast of creativity around the world because that original idea has been the inspiration of hundreds of scientific groups for the design of many versatile delivery systems based on mesoporous materials. Because the dream is not the destination, it is the journey, the present review aims to summarise the chain of events that catapulted a small and young research team from the grassroots of academia to the elite of the Biomedical Engineering field.

Chitosan-based inks for 3D printing and bioprinting

2021 ◽  
Author(s):  
Mohsen Taghizadeh ◽  
Ali Taghizadeh ◽  
Mohsen Khodadadi Yazdi ◽  
Payam Zarrintaj ◽  
Florian J. Stadler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Biomedical Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems

3D printing gave biomedical engineering great potential to mimic native tissues, accelerated regenerative medicine, and enlarged capacity of drug delivery systems; thus, advanced biomimetic functional biomaterial developed by 3D-printing for tissue engineering demands.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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