Preprocessing in Early Stage Detection of Diabetic Retinopathy Using Fundus Images

2015 ◽  
pp. 27-38 ◽  
Author(s):  
Vijay M. Mane ◽  
D. V. Jadhav ◽  
Ramish B. Kawadiwale
Keyword(s):  
Diabetic Retinopathy ◽  
Early Stage ◽  
Fundus Images

Two-Tier Grading System for NPDR Severities of Diabetic Retinopathy in Retinal Fundus Images

2020 ◽  
Vol 14 ◽  
Author(s):  
Charu Bhardwaj ◽  
Shruti Jain ◽  
Meenakshi Sood
Keyword(s):  
Diabetic Retinopathy ◽  
Statistical Analysis ◽  
Early Stage ◽  
Image Feature ◽  
Grading System ◽  
Fundus Images ◽  
Fundus Image ◽  
Retinal Fundus Images ◽  
Retinal Fundus ◽  
Timely Treatment

: Diabetic Retinopathy is the leading cause of vision impairment and its early stage diagnosis relies on regular monitoring and timely treatment for anomalies exhibiting subtle distinction among different severity grades. The existing Diabetic Retinopathy (DR) detection approaches are subjective, laborious and time consuming which can only be carried out by skilled professionals. All the patents related to DR detection and diagnoses applicable for our research problem were revised by the authors. The major limitation in classification of severities lies in poor discrimination between actual lesions, background noise and other anatomical structures. A robust and computationally efficient Two-Tier DR (2TDR) grading system is proposed in this paper to categorize various DR severities (mild, moderate and severe) present in retinal fundus images. In the proposed 2TDR grading system, input fundus image is subjected to background segmentation and the foreground fundus image is used for anomaly identification followed by GLCM feature extraction forming an image feature set. The novelty of our model lies in the exhaustive statistical analysis of extracted feature set to obtain optimal reduced image feature set employed further for classification. Classification outcomes are obtained for both extracted as well as reduced feature set to validate the significance of statistical analysis in severity classification and grading. For single tier classification stage, the proposed system achieves an overall accuracy of 100% by k- Nearest Neighbour (kNN) and Artificial Neural Network (ANN) classifier. In second tier classification stage an overall accuracy of 95.3% with kNN and 98.0% with ANN is achieved for all stages utilizing optimal reduced feature set. 2TDR system demonstrates overall improvement in classification performance by 2% and 6% for kNN and ANN respectively after feature set reduction, and also outperforms the accuracy obtained by other state of the art methods when applied to the MESSIDOR dataset. This application oriented work aids in accurate DR classification for effective diagnosis and timely treatment of severe retinal ailment.

scholarly journals Classification among Microaneurysms, Exudates, and Lesion free Retinal Regions in the Eye Images using Transfer Learned CNNs

2019 ◽  
Vol 9 (2) ◽  
pp. 5508-5512
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Diabetic Retinopathy ◽  
Glucose Level ◽  
Vision Loss ◽  
Early Stage ◽  
Training Data ◽  
Fundus Images ◽  
Diabetic Mellitus ◽  
Start Process

When pancreas fails to secrete sufficient insulin in the human body, the glucose level in blood either becomes too high or too low. This fluctuation in glucose level affects different body organs such as kidney, brain, and eye. When the complications start appearing in the eyes due to Diabetic Mellitus (DM), it is called Diabetic Retinopathy (DR). DR can be categorized in several classes based on the severity, it can be Microaneurysms (ME), Haemorrhages (HE), Hard and Soft Exudates (EX and SE). DR is a slow start process that starts with very mild symptoms, becomes moderate with the time and results in complete vision loss, if not detected on time. Early-stage detection may greatly bolster in vision loss. However, it is impassable to detect the symptoms of DR with naked eyes. Ophthalmologist harbor to the several approaches and algorithm which makes use of different Machine Learning (ML) methods and classifiers to overcome this disease. The burgeoning insistence of Convolutional Neural Network (CNN) and their advancement in extracting features from different fundus images captivate several researchers to strive on it. Transfer Learning (TL) techniques help to use pre-trained CNN on a dataset that has finite training data, especially that in under developing countries. In this work, we propose several CNN architecture along with distinct classifiers which segregate the different lesions (ME and EX) in DR images with very eye-catching accuracies.

scholarly journals Pengaruh Preprocessing Terhadap Klasifikasi Diabetic Retinopathy dengan Pendekatan Transfer Learning Convolutional Neural Network

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Juan Elisha Widyaya ◽  
Setia Budi
Keyword(s):  
Neural Network ◽  
Diabetic Retinopathy ◽  
Convolutional Neural Network ◽  
Early Stage ◽  
Careful Examination ◽  
Fundus Images ◽  
Fundus Image ◽  
Retinal Fundus Image ◽  
Retinal Fundus Images ◽  
Retinal Fundus

Diabetic retinopathy (DR) is eye diseases caused by diabetic mellitus or sugar diseases. If DR is detected in early stage, the blindness that follow can be prevented. Ophthalmologist or eye clinician usually decide the stage of DR from retinal fundus images. Careful examination of retinal fundus images is time consuming task and require experienced clinicians or ophthalmologist but a computer which has been trained to recognize the DR stages can diagnose and give result in real-time manner. One approach of algorithm to train a computer to recognize an image is deep learning Convolutional Neural Network (CNN). CNN allows a computer to learn the features of an image, in our case is retinal fundus image, automatically. Preprocessing is usually done before a CNN model is trained. In this study, four preprocessing were carried out. Of the four preprocessing tested, preprocessing with CLAHE and unsharp masking on the green channel of the retinal fundus image give the best results with an accuracy of 79.79%, 82.97% precision, 74.64% recall, and 95.81% AUC. The CNN architecture used is Inception v3.

A Survey on Prematurity Detection of Diabetic Retinopathy Based on Fundus Images Using Deep Learning Techniques

2021 ◽  
pp. 140-155
Author(s):  
Amiya Kumar Dash ◽  
Puspanjali Mohapatra
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Early Stage ◽  
Morphological Changes ◽  
Good Prognosis ◽  
Fundus Images ◽  
Fundus Image ◽  
Working Adults ◽  
Learning Techniques ◽  
Applications Of Machine Learning

Diabetic retinopathy (DR) is a disease related to eye correlated with long-standing diabetes. It is a leading cause of blindness among working adults. Detection of this condition in the early stage is critical for good prognosis. Present day detection of DR normally requires digital fundus image or images generated using optical coherence tomography (OCT). As OCT are high-priced, diagnosis of DR using fundus image will benefit for the patient and the ophthalmologists. Manual inspection of morphological changes in blood vessels, microaneurysms, exudates, hemorrhages, and macula are time consuming and tedious tasks. So, designing a computer-aided system helps in analyzing the morphological changes and identifying the DR. This chapter reviews the applications of machine learning and deep learning algorithms for detection of nonproliferative diabetic retinopathy by analyzing fundus images.

scholarly journals Modelling on-demand preprocessing framework towards practical approach in clinical analysis of diabetic retinopathy

2022 ◽  
Vol 12 (1) ◽  
pp. 585
Author(s):  
Prakruthi Mandya Krishnegowda ◽  
Komarasamy Ganesan
Keyword(s):  
Diabetic Retinopathy ◽  
Vision Loss ◽  
Early Stage ◽  
Signal To Noise Ratio ◽  
Clinical Analysis ◽  
Fundus Images ◽  
Aged People ◽  
On Demand ◽  
Fundus Imaging ◽  
Specific Objective

<p>Diabetic retinopathy (DR) refers to a complication of diabetes and a prime cause of vision loss in middle-aged people. A timely screening and diagnosis process can reduce the risk of blindness. Fundus imaging is mainly preferred in the clinical analysis of DR. However; the raw fundus images are usually subjected to artifacts, noise, low and varied contrast, which is very hard to process by human visual systems and automated systems. In the existing literature, many solutions are given to enhance the fundus image. However, such approaches are particular and limited to a specific objective that cannot address multiple fundus images. This paper has presented an on-demand preprocessing frame work that integrates different techniques to address geometrical issues, random noises, and comprehensive contrast enhancement solutions. The performance of each preprocessing process is evaluated against peak signal-to-noise ratio (PSNR), and brightness is quantified in the enhanced image. The motive of this paper is to offer a flexible approach of preprocessing mechanism that can meet image enhancement needs based on different preprocessing requirements to improve the quality of fundus imaging towards early-stage diabetic retinopathy identification.</p>

scholarly journals Identification of Diabetic Retinopathy from fundus images using CNNs

2019 ◽  
Vol 9 (1) ◽  
pp. 3439-3443
Keyword(s):  
Diabetic Retinopathy ◽  
Vision Loss ◽  
Early Stage ◽  
Human Vision ◽  
Learning Approach ◽  
Fundus Images ◽  
Diabetes Treatment ◽  
Proposed Model ◽  
Fine Tune ◽  
Better Than

the Diabetic Retinopathy is the diabetes-mellitus to human vision that is the main cause of vision loss. The early stage detection of diabetic retinopathy is can play eminent role in the diabetes treatment. The fundus of retinal image is utilized to recognize the symptoms of diabetic retinopathy. Moreover, the above phenomena led us to propose this paper; here we propose segment based learning approach for identification of diabetic retinopathy. The segment based image level is required to obtain the identification of diabetic retinopathy images, the classifiers and features are equally learned from the data. Then, we adapt pre-trained CNN as the fine tune to achieve the segment level estimation of diabetic retinopathy. For identification of diabetic retinopathy, we achieve accuracy 96.97 and 98.46% at 20 and 30% and also achieve AUC (Area under Curve) 97.51 and 98.50 at 20 and 30% on the Kaggle dataset. Our proposed model outperforms much better than other models.

Computerized Diabetic Retinopathy Diagnosis with Optimized Random Forest

2019 ◽  
Vol 9 (2) ◽  
pp. 274-283
Author(s):  
Xiaobo Lai ◽  
LV Lili ◽  
Zihe Huang
Keyword(s):  
Diabetic Retinopathy ◽  
Random Forest ◽  
Proliferative Diabetic Retinopathy ◽  
Screening Program ◽  
Early Stage ◽  
Treatment Plan ◽  
Texture Features ◽  
Cost Effective ◽  
Fundus Images ◽  
Diabetic Retinopathy Screening

It is desirable to diagnose diabetic retinopathy at an early stage for developing a suitable treatment plan to prevent the condition from deteriorating. To provide an immediate diagnosis of the retina, various methods have been investigated to realize a time and cost effective classification of the fundus images. However, most diabetic retinopathy automated identification methods are structural based analysis. Moreover, Asian fundus images have larger optic disc and thicker retinal vessels compared with Caucasians. Hence, we explore a machine learning approach to the extraction of texture features for classification and the feasibility of this approach using texture parameters to complement current algorithms. Normal retina, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy are identified in this paper. The first step is achieved with three groups of texture features such as gray level co-occurrence matric texture features, different statistical features and run length matrix texture features extracted. In the second step, these features are fed into an optimized random forest classifier for automatic classification. We test our system on two databases (D1 and D2) consisting of 432 and 579 fundus images from a diabetic retinopathy screening program consisting of Asians. The diabetic retinopathy is successfully diagnosed with sensitivity is 0.936 ± 0.019 for D1 and 0.941 ± 0.016 for D2, specificity is 0.917 ± 0.011 for D1 and 0.918 ± 0.011 for D2, positive predictive value is 0.924 ± 0.013 for D1 and 0.939 ± 0.012 for D2, when training on the same institutions, respectively.

Review of Various Tasks Performed in the Preprocessing Phase of a Diabetic Retinopathy Diagnosis System

2020 ◽  
Vol 16 (4) ◽  
pp. 397-426
Author(s):  
Muhammad Nadeem Ashraf ◽  
Muhammad Hussain ◽  
Zulfiqar Habib
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Vessels ◽  
Early Stage ◽  
Spherical Shape ◽  
Cost Effective ◽  
Lesion Detection ◽  
Diabetic Patients ◽  
Cad System ◽  
Non Invasive ◽  
Optic Discs

Diabetic Retinopathy (DR) is a major cause of blindness in diabetic patients. The increasing population of diabetic patients and difficulty to diagnose it at an early stage are limiting the screening capabilities of manual diagnosis by ophthalmologists. Color fundus images are widely used to detect DR lesions due to their comfortable, cost-effective and non-invasive acquisition procedure. Computer Aided Diagnosis (CAD) of DR based on these images can assist ophthalmologists and help in saving many sight years of diabetic patients. In a CAD system, preprocessing is a crucial phase, which significantly affects its performance. Commonly used preprocessing operations are the enhancement of poor contrast, balancing the illumination imbalance due to the spherical shape of a retina, noise reduction, image resizing to support multi-resolution, color normalization, extraction of a field of view (FOV), etc. Also, the presence of blood vessels and optic discs makes the lesion detection more challenging because these two artifacts exhibit specific attributes, which are similar to those of DR lesions. Preprocessing operations can be broadly divided into three categories: 1) fixing the native defects, 2) segmentation of blood vessels, and 3) localization and segmentation of optic discs. This paper presents a review of the state-of-the-art preprocessing techniques related to three categories of operations, highlighting their significant aspects and limitations. The survey is concluded with the most effective preprocessing methods, which have been shown to improve the accuracy and efficiency of the CAD systems.

scholarly journals Deep Learning for Diabetic Retinopathy Detection and Classification Based on Fundus Images: A Review

2021 ◽  
pp. 104599
Author(s):  
Nikos Tsiknakis ◽  
Dimitris Theodoropoulos ◽  
Georgios Manikis ◽  
Emmanouil Ktistakis ◽  
Ourania Boutsora ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Deep Learning ◽  
Fundus Images
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